A Novel Analytical Method Development of Esomeprazole Pellet

Abstract

Proton pump inhibitors (PPIs), also called gastric medicine, are among the most frequently prescribed medications globally. Medications such as Esomeprazole, Omeprazole, Pantoprazole, and others have nearly become ubiquitous in Bangladesh. Although available in various forms on the market, capsules (pellets) are the most prevalent. Analyzing pharmaceuticals is laborious because only a limited number of pharmaceutical companies produce them internally; the rest purchase granules that have been filled into capsule shells and sold. Thus, only a few in-house methods exist to facilitate the analytical process. The majority of them rely on pharmacopoeial methods such as BP and USP. Although these techniques are widely used, they may only apply to some pharmaceuticals. Therefore, this study is preoccupied with developing a novel technique to facilitate the analysis of PPI pellets. It is a finished product for a company that has only sold granules; it is a raw material for a purchaser. The analytical technique can, therefore, be identical for both. For an analyst to analyze these PPI granules, an effective method for both the primary material and the final product must exist. This analysis uses High-Performance Liquid Chromatography (HPLC), the most effective method for separating and identifying mixtures of various components. In addition, distinct reagent and chromatographic conditions are implemented, given that this is a novel methodology. The ultimate findings exhibit encouraging results. This approach reduces both time and analysis costs, albeit with minor drawbacks. Esomeprazole, PPI, particle analysis, HPLC, and the development of analytical methods are all keywords