Cytotoxic, Anti-oxidant and Thrombolytic Activity of Stem Extract of Boehmeria malabarica Wedd.

Abstract

The present study was carried out to open a new avenues for the improvement of medicinal uses of Boehmeria malabarica Wedd primarily for the evaluation of phytochemical screening, in vitro antioxidant and cytotoxicity potential. The phytochemical screening was determined through qualitative analysis which indicates the presence of chemical constituents such as alkaloids, flavonoids, glycosides and tannins. The cytotoxic potential was determined by using brine shrimp lethality bioassay, and showed an LC50 of methanol extract and LC50 values of standard vincristine. The antioxidant activity was determined by using DPPH (1,1-diphenyl-2- picrylhydrazine). Extract showed DPPH scavenging that was comparable to standard ascorbic acid . The present study demonstrates that methanol extract of Boehmeria malabarica Wedd stem has significant antioxidant and cytotoxic effect and thrombolytic effect