Formulation Development and Evaluation of Chloramphenicol Microencapsule by Ionotropic Gelation Method

Abstract

The advantages of microencapsule is to prevent the sensitive drug from contamination and to ensure the controlled or sustained release of drug. It has a purpose to ensure the targeted drug delivery to avoid the gastrointestinal fluid and enhance flow, compaction and core compression characteristics. Chloramphenicol is an effective antibiotic for certain bacterial infections which includes the usage of conjunctivitis as an eye treatment and meningitis, plague, cholera and typhoid fever are treated by oral or injections into the vein. The aim of the study as Chloramphenicol is X category drug for pregnant women then we can prevent the teratogenic properties of this drug by micro encapsulant formulation. Ionotropic gelation method is one of the safest and cost effective technique for microencapsulation. It is the easiest and effective method for the Chloramphenicol micro encapsulant. Sustained release oral product namely microbeads for Chloramphenicol prepared by ionotropic gelation technique using Sodium alginate alone and combination with Hydroxypropyl methyl cellulose as release rate modifiers, and investigated for in vitro drug release potential. While increase in the concentration of sodium alginate and other polymer dispersions increased, the amount release of drug is controlled due to time interval . In vitro drug release was dependent on the pH of the medium and concentration of polymer dispersions. Among the six formulation batches F4, F5 and F6 were found to show optimum sustained effect 99.984%, 99.598% and 99.1972% respectively. The mechanism of drug release from the microbeads was found to be followed super case-II transport. Finally it has been determined that when the concentration of the polymers increase it can ensure more controlled release of drug.