A review on the association of SNP at rs731236 of VDR Gene and different diseases in various ethnicity

Abstract

There is much of information on vitamin D's importance in bone metabolism, but less is known about how it affects other organs or systems. Vitamin D is receptor is found in the kidney, pancreas, prostate, gut, platelets, and immune cells where it is synthesizing 1- hydroxylase enzyme showing that it is actively connected in these cell populations and disorders related to them. Diseases like rheumatoid arthritis, Behcets diseases, osteoporosis, allergic disease and renal dysfunction. The frequency of genotype and alleles of various VDR polymorphism with such disorders in Egyptian, Tunisian, Caucasian, Asian, German, Spanish and some other European population has proved to be connected. The only suggested treatment to maintain the homeostasis of Vitamin-d to regulate normal VDR activity is vitamin D supplementation though more research work should be done focusing VDR polymorphism related diseases and their treatment.