Comparative study of antihyperglycemic and antihyperlipidemic activities of aqueous extract of Momordica charantia (bitter gourd) and Coccinia indica (Telakucha) leaves in normal and alloxan diabetic rats

Abstract

ABSTRACT

Effective and safer hypoglycemic agents from herbal plants are being considered as area of research as the synthetic oral anti-diabetic agents have several serious adverse effects. The aim of this research was to investigate the single and combined effect of Momordica charantia (bitter gourd) and Coccinia indica (Telakucha) leaves on blood glucose and cholesterol in diabetic rats. In this study 60 rats were divided into 5 groups and containing 12 individuals as follows: normal control (A), diabetic control (B), Alloxan with BG treated (C), Alloxan and TK treated (D) and Group E was Alloxan, BG and TK treated. Alloxan was injected at the dose of 100mg/kg body weight intra-peritoneal to each rat to induce diabetes in groups B, C, D and E. Aqueous extract of BG and TK were fed at a dose of 300mg/kg and 500 mg/kg body weight for 21 days in group C and D, respectively and combined in group E. The body weight, blood cholesterol (mg/dl) and glucose (mg/dl) level were measured on Day 0, 7, 14 and 21. The blood sugar and cholesterol level were reduced in Group C from 178.5±11.55 mg/dl to 120.45±1.98 mg/dl and 209.11±5.24 mg/dl to 126.66±6.58 mg/dl respectively and in group D, they reduced from 150.5±1.6 to 140.17±2.49 mg/dl and 212.43±6.2 to 129.77±5.94 mg/dl respectively. But the reduction of blood sugar level and blood cholesterol level were significant in Group E from 156±4.11 mg/dl to 110.21±3.98 mg/dl and 217.17±4.34 mg/dl to 114.81±4.18 mg/dl, respectively. From these findings it concluded that the combination of BG and TK can be used as anti-hyperglycemic and anti-hypercholesterolemic agent.