In vitro antimicrobial and antiarthritic effects of methanolic extract of Zanthoxylum rhetsa leaves

Abstract

The antimicrobial study of Zanthoxylum rhetsa leaves methanol extract was evaluated by the disc diffusion method against some pathogenic organisms. It exhibits the activity against almost all the test bacterial and fungal species with the zone of inhibition from mild to moderate in different concentrations- 100, 300 and 500 μg/disc where microbial species exhibits from minimum 10 to maximum 27 mm zone of inhibition. The Antiarthritic test have also done by using six concentrations for UV absorbance of test solution, product control solution, test control solution and percentage of inhibition of methanolic extract of Z. rhetsa with comparison of standard Diclofenac sodium in different concentrations like 31.75 μg/mL, 62.5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL and 1000 μg/mL where different concentrations showed an increase in all the parameters that was significant from test, control and standard groups. The present study indicates that, the extract has both antibacterial and antifungal activity from mild to moderately in different concentrations and has significantly antiarthritic activities.