In Vitro Assessment of Cholinesterase Inhibitory and Antioxidant Activities of root and Rhizome of Curcuma Caesia (L.) for the Treatment of Neurodegenerative Disorder

Abstract

Oxidative stress and low level of neurotransmitter (especially acetylcholine) are main characteristics of Alzheimer’s disease (AD), a progressive neurodegenerative disease. Prolonging the function of acetylcholine by inhibiting acetylcholinesterase or butyrylcholinesterase enzyme and reducing oxidative stress with antioxidants are most effective treatment therapy of AD. Curcuma caesia is a well-known medicine plant with a variety of medicinal uses. In this study we examine cholinesterase inhibitory activity as well as antioxidant activity of dried root and rhizome extract. Both cholinergic inhibitory activity and antioxidant activity of various fractions suggested that, this crude methyl extract of root and rhizome have moderate anticholinester activity with moderate antioxidant activity which can be used as a lead to most prominent drug for the symptomatic treatment of AD.