Common Genes Findings and Key Pathways Detections of Shared Genes Between Severe Acute Respiratory Syndrome Coronavirus 2 and Cystic Fibrosis

Abstract

A comparative transcriptomic analysis has performed to establish essential profiles of the gene expression of SARS-CoV-2 linked to Cystic Fibrosis (CF). Transcriptomic studies have been carried out in relation to SARS-CoV-2 since a number of people have been diagnosed with CF. The recognition of differentially expressed genes demonstrated 8 concordant genes shared between the SARS-CoV-2 and CF. Extensive gene ontology analysis and the discovery of pathways enrichment demonstrated SARS-CoV-2 response to the CF. The gene ontological terms and pathways enrichment mechanisms derived from this research may affect the production of successful drugs, especially for the people with the following disorder. Identification of TFmiRNA association network reveals the interconnection between TF genes and miRNAs, which may effective to reveals the other influenced disease that occurs for SARS-CoV-2 to CF. The enrichment of pathways reveals SARS-CoV-2 associate CF mostly engaged with the type of Innate Immune System, Toll-like receptor signaling pathway, Pantothenate and CoA biosynthesis, Allograft rejection, Graft-versus-host disease, Intestinal immune network for IgA production, Mineral absorption, Autoimmune thyroid disease, Legionellosis, Viral myocarditis, Inflammatory bowel disease (IBD), etc. The drug compounds identification demonstrates the drug targets of IMIQUIMOD and raloxifene are the most significant with the significant hub DEGs.