Bioinformatics analyses of key regulators of NF-κB pathway in relation with small cell lung carcinoma

Abstract

Small cell lung cancer is the most aggressive form of cancer and its progression is very fast and quick. The NF-kB pathway and small cell lung cancer are connected to each other. Despite all the findings and the advanced technologies, due to its challenges associated with its aggressive progressions of small cell lung cancer, only few clinical trials are currently available for SCLC. It has limited treatment options and lacks the targetable biomarkers (Patel & Das, 2023). The NF-kB pathway extensively regulates the pathogenesis of SCLC by promoting tumor development and progression. Additionally, the irregular activation of NF-κB can lead inflammation, development of the autoimmune diseases and malignant disorders, namely atherosclerosis and malignant neoplasm (Park & Hong, 2016). Therefore, it's important to understand and to identify how NF-κB pathway influences the progression of the cancer in the SCLC through the application of the various bioinformatics tools. This study highlights how NF-κB pathway influences the progression of the cancer. The present study also helps in the identification of the key genes that are responsible for SCLC in the NF-κB pathway using the spearman’s correlation limit, finding the numbers of correlated genes and filtering the genes by using different bioinformatics techniques and approaches. NFKB2, ITGB2, PRKCD, RELB, BCL3, STAT6 and RIPK1 play critical role in the cellular growth and progression, cell survival, apoptosis, immune response and survival of the cancer patients. Finally, understanding the survival rate of the patient and pinpointing the critical pathways that can be targeted.