In Vivo Evaluation of Analgesic, Anti-Inflammatory and Antidiabetic Activities of Methanol Extract of Carallia Brachiata L. Leaves

Abstract

Most of analgesic and anti-inflammatory drugs cause hyperacidity and peptic ulcer. The present study was carried out to evaluate analgesic, anti-inflammatory and anti-diabetic activities of methanol extract of Carallia brachiata L. leaves on experimental mice. Carallia brachiata L. leaves showed significant analgesic effects (*p<0.01) on acetic acid induced writhing of mice compared to the control group where diclofenac sodium was used as standard.Carallia brachiata L. leaves decreased thecarrageenan induced paw edma notably (*p<0.05 and **p<0.01) compare to control group in which standard was diclofenac sodium. The methanol extract of Carallia brachiata L. leaves was administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduced blood lipid level (Total cholesterol and Triglycerides) significantly (*p<0.05). The extract also exhibited correlation of altered biochemical parameters viz., SGOT and SGPT levels in diabetic rates. The effect of plant extract was compared with the standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpenes, alkaloids and flavonoids etc. were present in the plant which hasanalgesic, anti-inflammatory and anti-diabetic properties but further study neededto evaluate the mechanism of action of antidiabetic activities of Carallia brachiata L