“Evaluation of anti-diabetic and anti-inflammatory activity of selective phytoconstituents from Hyptis suaveolens (L.) Poit: an in silico molecular docking and ADMET study

Abstract

The use of medicinal plants to treat DM and Inflammation is popular, as herbal drugs are generally regarded as free of toxic effects. Moreover, the limitations of oral anti-diabetic and anti-inflammatory drugs urge to find new drugs for treatment of DM and inflammation. Therefore, the search for more effective and safer herbal hypoglycemic agents, anti-inflammatory agents and developing new anti-diabetic drugs, anti-inflammatory drugs with improved clinical profiles simultaneously have become an area of active research. Numerous animal studies have shown positive anti-inflammatory and antioxidant capabilities of several physiologically active compounds present in plant extracts. It is yet unclear how these substances, which are found in phytochemical extracts, interact molecularly with the target proteins or enzymes that provide antioxidant and anti-inflammatory properties..