Development of a High-sensitive Refractive Index and Temperature Nano-sensor
Date
2021-02-15
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Department of Electrical and Electronic Engineering, Islamic University of Technology,Board Bazar, Gazipur, Bangladesh
Abstract
High perform lab-on-chip sensors packaged in a miniaturized form are replacing the
bulky sensors in the point-of-care detection and allowing rapid triage, treatment, or
discharge of patients. To satisfy the requirements of label-free detection, low cost, fast
response of a lab-on-chip biosensor, a nanodot enhanced metal-insulator-metal (MIM)
waveguide based refractive index sensor coupled with three rectangular cavities, is proposed
in this work. Numerical investigation of the transmission spectra, employing the
finite element method (FEM), exhibits a linear correspondence with the refractive index,
which is used to sense the unknown materials. With the initial structural setup, the
proposed sensor demonstrates a maximum sensitivity and FOM as 5016 nmRIU1
and 144, respectively. Imposing a sequential optimization of the structural parameters
and enhancing light-matter interaction by loading nanodots at the high E-field confined
areas, desired sensitivity (S) and figure of merit (FOM) are upgraded to 7564
nmRIU1 and 120, respectively. The proposed sensor’s temperature sensing capability
is explored by filling the sensing media with alcohol and polydimethylsiloxane
(PDMS). Maximum temperature sensitivity of 2:68 nm0C1 operating from 1000C
to 600C is recorded, while for polydimethylsiloxane, the maximum temperature sensitivity
of 3:40 nm0C1 for 200C to 700C operating range is recorded. Furthermore, this
work addresses some recent plasmonic sensors’ shortcomings in the selective detection
of a single element from a complex solution (e.g., blood sample) and proposed a sample
preparation model combining purification, molecular separation, and concentration
enhancement prior to the selective detection of Na+, K+, and glucose concentration in
the human blood. A refractive index model for this purpose, is developed that exposes
a maximum shift of 0:83 nm, 1:23 nm, and 8:72 nm of the transmittance peak
for the concentration variation of 1 mgdL1 in Na+, K+, and glucose solution easily
differentiable by the modern spectrometer. With such excellent performance metrics,
compact size, and simple to use feature, the proposed sensor is expected to bring a
notable solution in the point-of-care detection.
Description
Supervised by
Dr. Rakibul Hasan Sagor,
Associate Professor,
Electrical and Electronic Engineering Department,
Islamic University of Technology (IUT), Gazipur.
Keywords
Citation
[1] N. Kazanskiy, S. Khonina, and M. Butt, “Plasmonic sensors based on metalinsulator- metal waveguides for refractive index sensing applications: A brief review,” Physica E: Low-dimensional Systems and Nanostructures, vol. 117, p. 113798, 2020. [2] Z. Zhu, L. Liu, Z. Liu, Y. Zhang, and Y. Zhang, “Surface-plasmon-resonancebased optical-fiber temperature sensor with high sensitivity and high figure of merit,” Optics letters, vol. 42, no. 15, pp. 2948–2951, 2017. [3] H. Li, L. Lin, and S. Xie, “Refractive index of human whole blood with different types in the visible and near-infrared ranges,” in Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, vol. 3914. International Society for Optics and Photonics, 2000, pp. 517–521. [4] Y. Tang, Z. Zhang, R. Wang, Z. Hai, C. Xue, W. Zhang, and S. Yan, “Refractive index sensor based on fano resonances in metal-insulator-metal waveguides coupled with resonators,” Sensors, vol. 17, no. 4, p. 784, 2017. [5] Z. Zhang, J. Yang, X. He, J. Zhang, J. Huang, D. Chen, and Y. Han, “Plasmonic refractive index sensor with high figure of merit based on concentric-rings resonator,” Sensors, vol. 18, no. 1, p. 116, 2018. [6] M. Butt, N. Kazanskiy, and S. Khonina, “Highly integrated plasmonic sensor design for the simultaneous detection of multiple analytes,” Current Applied Physics, vol. 20, no. 11, pp. 1274–1280, 2020. [7] M. R. Rakhshani and M. A. Mansouri-Birjandi, “Engineering hexagonal array of nanoholes for high sensitivity biosensor and application for human blood group detection,” IEEE Transactions on Nanotechnology, vol. 17, no. 3, pp. 475–481, 2018. [8] ——, “High sensitivity plasmonic refractive index sensing and its application for human blood group identification,” Sensors and Actuators B: Chemical, vol. 249, pp. 168–176, 2017. 76 [9] N. Kazanskiy, M. Butt, and S. Khonina, “Nanodots decorated mim semiring resonator cavity for biochemical sensing applications,” Photonics and Nanostructures-Fundamentals and Applications, vol. 42, p. 100836, 2020. [10] Z. Chen, L. Yu, L. Wang, G. Duan, Y. Zhao, and J. Xiao, “A refractive index nanosensor based on fano resonance in the plasmonic waveguide system,” IEEE Photonics Technology Letters, vol. 27, no. 16, pp. 1695–1698, 2015. [11] M. Yahya and M. Saghir, “Empirical modelling to predict the refractive index of human blood,” Physics in Medicine & Biology, vol. 61, no. 4, p. 1405, 2016. [12] M. R. Rakhshani and M. A. Mansouri-Birjandi, “Dual wavelength demultiplexer based on metal–insulator–metal plasmonic circular ring resonators,” Journal of Modern Optics, vol. 63, no. 11, pp. 1078–1086, 2016. [13] A. D. Raki´c, A. B. Djuriši´c, J. M. Elazar, and M. L. Majewski, “Optical properties of metallic films for vertical-cavity optoelectronic devices,” Applied optics, vol. 37, no. 22, pp. 5271–5283, 1998. [14] W. L. Barnes, A. Dereux, and T. W. Ebbesen, “Surface plasmon subwavelength optics,” nature, vol. 424, no. 6950, pp. 824–830, 2003. [15] V. V. Temnov, G. Armelles, U. Woggon, D. Guzatov, A. Cebollada, A. Garcia- Martin, J.-M. Garcia-Martin, T. Thomay, A. Leitenstorfer, and R. Bratschitsch, “Active magneto-plasmonics in hybrid metal–ferromagnet structures,” Nature Photonics, vol. 4, no. 2, pp. 107–111, 2010. [16] D. K. Gramotnev and S. I. Bozhevolnyi, “Plasmonics beyond the diffraction limit,” Nature photonics, vol. 4, no. 2, pp. 83–91, 2010. [17] Y. Fang and M. Sun, “Nanoplasmonic waveguides: towards applications in integrated nanophotonic circuits,” Light: Science & Applications, vol. 4, no. 6, pp. e294–e294, 2015. [18] M. F. Hassan, R. H. Sagor, I. Tathfif, K. S. Rashid, and M. Radoan, “An optimized dielectric-metal-dielectric refractive index nanosensor,” IEEE Sensors Journal, vol. 21, no. 2, pp. 1461–1469, 2020. [19] M. Rahmatiyar, M. Afsahi, and M. Danaie, “Design of a refractive index plasmonic sensor based on a ring resonator coupled to a mim waveguide containing tapered defects,” Plasmonics, vol. 15, no. 6, pp. 2169–2176, 2020. [20] M. R. Rakhshani, “Optical refractive index sensor with two plasmonic doublesquare resonators for simultaneous sensing of human blood groups,” Photonics and Nanostructures-Fundamentals and Applications, vol. 39, p. 100768, 2020. 77 [21] Y.-J. Guo, K.-D. Xu, X. Deng, X. Cheng, and Q. Chen, “Millimeter-wave onchip bandpass filter based on spoof surface plasmon polaritons,” IEEE Electron Device Letters, vol. 41, no. 8, pp. 1165–1168, 2020. [22] E. Forati and G. W. Hanson, “Surface plasmon polaritons on soft-boundary graphene nanoribbons and their application in switching/demultiplexing,” Applied Physics Letters, vol. 103, no. 13, p. 133104, 2013. [23] R. H. Sagor, M. S. I. Sumon, and M. Tazwar, “Design and analysis of a novel air gap–based semi-elliptical nanoplasmonic coupler,” Plasmonics, vol. 14, no. 6, pp. 1993–2001, 2019. [24] Y.-F. C. Chau, “Mid-infrared sensing properties of a plasmonic metal–insulator– metal waveguide with a single stub including defects,” Journal of Physics D: Applied Physics, vol. 53, no. 11, p. 115401, 2020. [25] S. Zou, F. Wang, R. Liang, L. Xiao, and M. Hu, “A nanoscale refractive index sensor based on asymmetric plasmonic waveguide with a ring resonator: A review,” IEEE Sensors Journal, vol. 15, no. 2, pp. 646–650, 2014. [26] S. Ghorbani, M. Sadeghi, and Z. Adelpour, “A highly sensitive and compact plasmonic ring nano-biosensor for monitoring glucose concentration,” Laser Physics, vol. 30, no. 2, p. 026204, 2019. [27] R. H. Sagor, M. F. Hassan, S. Sharmin, T. Z. Adry, and M. A. R. Emon, “Numerical investigation of an optimized plasmonic on-chip refractive index sensor for temperature and blood group detection,” Results in Physics, vol. 19, p. 103611, 2020. [28] Z. Zhang, J. Yang, X. He, J. Zhang, J. Huang, D. Chen, and Y. Han, “Plasmonic refractive index sensor with high figure of merit based on concentric-rings resonator,” Sensors, vol. 18, no. 1, p. 116, 2018. [29] G. Qiu, Z. Gai, Y. Tao, J. Schmitt, G. A. Kullak-Ublick, and J. Wang, “Dualfunctional plasmonic photothermal biosensors for highly accurate severe acute respiratory syndrome coronavirus 2 detection,” ACS nano, vol. 14, no. 5, pp. 5268–5277, 2020. [30] S. Zou, F. Wang, R. Liang, L. Xiao, and M. Hu, “A nanoscale refractive index sensor based on asymmetric plasmonic waveguide with a ring resonator: A review,” IEEE Sensors Journal, vol. 15, no. 2, pp. 646–650, 2014. [31] G. Qiu, Z. Gai, Y. Tao, J. Schmitt, G. A. Kullak-Ublick, and J. Wang, “Dualfunctional plasmonic photothermal biosensors for highly accurate severe acute respiratory syndrome coronavirus 2 detection,” ACS nano, vol. 14, no. 5, pp. 5268–5277, 2020. 78 [32] M. A. Jabin, K. Ahmed, M. J. Rana, B. K. Paul, M. Islam, D. Vigneswaran, and M. S. Uddin, “Surface plasmon resonance based titanium coated biosensor for cancer cell detection,” IEEE Photonics J, vol. 11, no. 4, pp. 1–10, 2019. [33] R. H. Sagor, M. F. Hassan, A. A. Yaseer, E. Surid, and M. I. Ahmed, “Highly sensitive refractive index sensor optimized for blood group sensing utilizing the fano resonance,” Applied Nanoscience, pp. 1–14, 2020. [34] K. Ahmed, F. Ahmed, S. Roy, B. K. Paul, M. N. Aktar, D. Vigneswaran, and M. S. Islam, “Refractive index-based blood components sensing in terahertz spectrum,” IEEE Sensors Journal, vol. 19, no. 9, pp. 3368–3375, 2019. [35] C.-Y. Tan and Y.-X. Huang, “Dependence of refractive index on concentration and temperature in electrolyte solution, polar solution, nonpolar solution, and protein solution,” Journal of Chemical & Engineering Data, vol. 60, no. 10, pp. 2827–2833, 2015. [36] K. E. You, N. Uddin, T. H. Kim, Q. H. Fan, and H. J. Yoon, “Highly sensitive detection of biological substances using microfluidic enhanced fabry-perot etalon-based optical biosensors,” Sensors and Actuators B: Chemical, vol. 277, pp. 62–68, 2018. [37] A. K. Sharma, R. Jha, H. S. Pattanaik, and G. J. Mohr, “Design considerations for surface plasmon resonance-based fiber-optic detection of human blood group,” Journal of biomedical optics, vol. 14, no. 6, p. 064041, 2009. [38] H. H. Goldstine and A. Goldstine, “The electronic numerical integrator and computer (eniac),” IEEE Annals of the History of Computing, vol. 18, no. 1, pp. 10–16, 1996. [39] T. Haigh, P. M. Priestley, M. Priestley, and C. Rope, ENIAC in action: Making and remaking the modern computer. MIT press, 2016. [40] D. A. B. Miller and H. M. Ozaktas, “Limit to the bit-rate capacity of electrical interconnects from the aspect ratio of the system architecture,” Journal of parallel and distributed computing, vol. 41, no. 1, pp. 42–52, 1997. [41] M. Horowitz, C.-K. K. Yang, and S. Sidiropoulos, “High-speed electrical signaling: Overview and limitations,” IEEE Micro, vol. 18, no. 1, pp. 12–24, 1998. [42] S. C. Esener, “Implementation and prospects for chip-to-chip free-space optical interconnects,” in International Electron Devices Meeting. Technical Digest (Cat. No. 01CH37224). IEEE, 2001, pp. 23–5. [43] B. Hecht, H. Bielefeldt, L. Novotny, Y. Inouye, and D. Pohl, “Local excitation, scattering, and interference of surface plasmons,” Physical review letters, vol. 77, no. 9, p. 1889, 1996. 79 [44] M. Butt, N. Kazanskiy, and S. Khonina, “Nanodots decorated asymmetric metal–insulator–metal waveguide resonator structure based on fano resonances for refractive index sensing application,” Laser Physics, vol. 30, no. 7, p. 076204, 2020. [45] Y. Tang, Z. Zhang, R. Wang, Z. Hai, C. Xue, W. Zhang, and S. Yan, “Refractive index sensor based on fano resonances in metal-insulator-metal waveguides coupled with resonators,” Sensors, vol. 17, no. 4, p. 784, 2017. [46] N. Amoosoltani, N. Yasrebi, A. Farmani, and A. Zarifkar, “A plasmonic nanobiosensor based on two consecutive disk resonators and unidirectional reflectionless propagation effect,” IEEE Sensors Journal, 2020. [47] M. A. A. Butt and N. Kazanskiy, “Enhancing the sensitivity of a standard plasmonic mim square ring resonator by incorporating the nano-dots in the cavity,” Photonics Letters of Poland, vol. 12, no. 1, pp. 1–3, 2020. [48] B. Ni, X. Chen, D. Xiong, H. Liu, G. Hua, J. Chang, J. Zhang, and H. Zhou, “Infrared plasmonic refractive index-sensitive nanosensor based on electromagnetically induced transparency of waveguide resonator systems,” Optical and Quantum Electronics, vol. 47, no. 6, pp. 1339–1346, 2015. [49] S.-B. Yan, L. Luo, C.-Y. Xue, and Z.-D. Zhang, “A refractive index sensor based on a metal-insulator-metal waveguide-coupled ring resonator,” Sensors, vol. 15, no. 11, pp. 29 183–29 191, 2015. [50] R. Zafar and M. Salim, “Enhanced figure of merit in fano resonance-based plasmonic refractive index sensor,” IEEE Sensors Journal, vol. 15, no. 11, pp. 6313– 6317, 2015. [51] Z. Chen, L. Yu, L. Wang, G. Duan, Y. Zhao, and J. Xiao, “A refractive index nanosensor based on fano resonance in the plasmonic waveguide system,” IEEE Photonics Technology Letters, vol. 27, no. 16, pp. 1695–1698, 2015. [52] Y.-Y. Xie, Y.-X. Huang, W.-L. Zhao, W.-H. Xu, and C. He, “A novel plasmonic sensor based on metal–insulator–metal waveguide with side-coupled hexagonal cavity,” IEEE Photonics Journal, vol. 7, no. 2, pp. 1–12, 2015. [53] X. Zhang, M. Shao, and X. Zeng, “High quality plasmonic sensors based on fano resonances created through cascading double asymmetric cavities,” Sensors, vol. 16, no. 10, p. 1730, 2016. [54] Z. Zhang, L. Luo, C. Xue, W. Zhang, and S. Yan, “Fano resonance based on metal-insulator-metal waveguide-coupled double rectangular cavities for plasmonic nanosensors,” Sensors, vol. 16, no. 5, p. 642, 2016. 80 [55] F. Chen and D. Yao, “Realizing of plasmon fano resonance with a metal nanowall moving along mim waveguide,” Optics Communications, vol. 369, pp. 72–78, 2016. [56] L. Chen, Y. Liu, Z. Yu, D.Wu, R. Ma, Y. Zhang, and H. Ye, “Numerical analysis of a near-infrared plasmonic refractive index sensor with high figure of merit based on a fillet cavity,” Optics express, vol. 24, no. 9, pp. 9975–9983, 2016. [57] M. R. Rakhshani and M. A. Mansouri-Birjandi, “High-sensitivity plasmonic sensor based on metal–insulator–metal waveguide and hexagonal-ring cavity,” IEEE Sensors Journal, vol. 16, no. 9, pp. 3041–3046, 2016. [58] C. Wu, H. Ding, T. Huang, X. Wu, B. Chen, K. Ren, and S. Fu, “Plasmoninduced transparency and refractive index sensing in side-coupled stub-hexagon resonators,” Plasmonics, vol. 13, no. 1, pp. 251–257, 2018. [59] J. Zhou, H. Chen, Z. Zhang, J. Tang, J. Cui, C. Xue, and S. Yan, “Transmission and refractive index sensing based on fano resonance in mim waveguidecoupled trapezoid cavity,” AIP Advances, vol. 7, no. 1, p. 015020, 2017. [60] A. Akhavan, H. Ghafoorifard, S. Abdolhosseini, and H. Habibiyan, “Plasmoninduced transparency based on a triangle cavity coupled with an ellipse-ring resonator,” Applied optics, vol. 56, no. 34, pp. 9556–9563, 2017. [61] M. R. Rakhshani and M. A. Mansouri-Birjandi, “Utilizing the metallic nanorods in hexagonal configuration to enhance sensitivity of the plasmonic racetrack resonator in sensing application,” Plasmonics, vol. 12, no. 4, pp. 999– 1006, 2017. [62] M. Butt, S. Khonina, and N. Kazanskiy, “Hybrid plasmonic waveguide-assisted metal–insulator–metal ring resonator for refractive index sensing,” Journal of Modern Optics, vol. 65, no. 9, pp. 1135–1140, 2018. [63] A. Akhavan, H. Ghafoorifard, S. Abdolhosseini, and H. Habibiyan, “Metal– insulator–metal waveguide-coupled asymmetric resonators for sensing and slow light applications,” IET Optoelectronics, vol. 12, no. 5, pp. 220–227, 2018. [64] R. Zafar, S. Nawaz, G. Singh, A. d’Alessandro, and M. Salim, “Plasmonicsbased refractive index sensor for detection of hemoglobin concentration,” IEEE Sensors Journal, vol. 18, no. 11, pp. 4372–4377, 2018. [65] X. Zhang, Y. Qi, P. Zhou, H. Gong, B. Hu, and C. Yan, “Refractive index sensor based on fano resonances in plasmonic waveguide with dual side-coupled ring resonators,” Photonic Sensors, vol. 8, no. 4, pp. 367–374, 2018. 81 [66] M. J. Al Mahmod, R. Hyder, and M. Z. Islam, “A highly sensitive metal– insulator–metal ring resonator-based nanophotonic structure for biosensing applications,” IEEE Sensors Journal, vol. 18, no. 16, pp. 6563–6568, 2018. [67] S. Ghorbani, M. A. Dashti, and M. Jabbari, “Plasmonic nano-sensor based on metal-dielectric-metal waveguide with the octagonal cavity ring,” Laser Physics, vol. 28, no. 6, p. 066208, 2018. [68] X. Yi, J. Tian, and R. Yang, “Tunable fano resonance in mdm stub waveguide coupled with a u-shaped cavity,” The European Physical Journal D, vol. 72, no. 4, p. 60, 2018. [69] M. Danaie and A. Shahzadi, “Design of a high-resolution metal–insulator–metal plasmonic refractive index sensor based on a ring-shaped si resonator,” Plasmonics, vol. 14, no. 6, pp. 1453–1465, 2019. [70] M. Butt, S. Khonina, and N. Kazanskiy, “A plasmonic colour filter and refractive index sensor applications based on metal–insulator–metal square micro-ring cavities,” Laser Physics, vol. 30, no. 1, p. 016205, 2019. [71] Y. Zhang and M. Cui, “Refractive index sensor based on the symmetric mim waveguide structure,” Journal of Electronic Materials, vol. 48, no. 2, pp. 1005– 1010, 2019. [72] M. Butt, S. Khonina, and N. Kazanskiy, “Plasmonic refractive index sensor based on metal–insulator-metal waveguides with high sensitivity,” Journal of Modern Optics, vol. 66, no. 9, pp. 1038–1043, 2019. [73] Z. Li, K. Wen, L. Chen, L. Lei, J. Zhou, D. Zhou, Y. Fang, and B. Wu, “Control of multiple fano resonances based on a subwavelength mim coupled cavities system,” IEEE Access, vol. 7, pp. 59 369–59 375, 2019. [74] X. Yang, E. Hua, M. Wang, Y. Wang, F. Wen, and S. Yan, “Fano resonance in a mim waveguide with two triangle stubs coupled with a split-ring nanocavity for sensing application,” Sensors, vol. 19, no. 22, p. 4972, 2019. [75] M. F. Hassan, M. M. Hasan, M. I. Ahmed, and R. H. Sagor, “Numerical investigation of a plasmonic refractive index sensor based on rectangular mim topology,” in 2020 International Seminar on Intelligent Technology and Its Applications (ISITIA). IEEE, 2020, pp. 77–82. [76] M. F. Hassan, I. Tathfif, M. Radoan, and R. H. Sagor, “A concentric double-ring resonator based plasmonic refractive index sensor with glucose sensing capability,” in 2020 IEEE REGION 10 CONFERENCE (TENCON). IEEE, 2020, pp. 91–96. 82 [77] M. Bazgir, M. Jalalpour, F. B. Zarrabi, and A. S. Arezoomand, “Design of an optical switch and sensor based on a mim coupled waveguide using a dna composite,” Journal of Electronic Materials, vol. 49, no. 3, pp. 2173–2178, 2020. [78] M. R. Rakhshani and M. A. Mansouri-Birjandi, “A high-sensitivity sensor based on three-dimensional metal–insulator–metal racetrack resonator and application for hemoglobin detection,” Photonics and Nanostructures-Fundamentals and Applications, vol. 32, pp. 28–34, 2018. [79] K. E. You, N. Uddin, T. H. Kim, Q. H. Fan, and H. J. Yoon, “Highly sensitive detection of biological substances using microfluidic enhanced fabry-perot etalon-based optical biosensors,” Sensors and Actuators B: Chemical, vol. 277, pp. 62–68, 2018. [80] M. R. Rakhshani, “Fano resonances based on plasmonic square resonator with high figure of merits and its application in glucose concentrations sensing,” Optical and Quantum Electronics, vol. 51, no. 9, pp. 1–16, 2019. [81] C. S. Desai and J. F. Abel, Introduction to the finite element method; a numerical method for engineering analysis. Van Nostrand Reinhold, 1971. [82] M. N. Sadiku, Numerical techniques in electromagnetics with MATLAB. CRC press, 2018. [83] D. G. Rabus, Integrated ring resonators. Springer, 2007. [84] M. Butt, S. Khonina, and N. Kazanskiy, “Plasmonic refractive index sensor based on mim square ring resonator,” in 2018 International Conference on Computing, Electronic and Electrical Engineering (ICE Cube). IEEE, 2018, pp. 1–4. [85] N. Kazanskiy, M. Butt, and S. Khonina, “Nanodots decorated mim semiring resonator cavity for biochemical sensing applications,” Photonics and Nanostructures-Fundamentals and Applications, vol. 42, p. 100836, 2020. [86] W. K. Jung and K. M. Byun, “Fabrication of nanoscale plasmonic structures and their applications to photonic devices and biosensors,” Biomedical Engineering Letters, vol. 1, no. 3, p. 153, 2011. [87] S.-W. Lee, K.-S. Lee, J. Ahn, J.-J. Lee, M.-G. Kim, and Y.-B. Shin, “Highly sensitive biosensing using arrays of plasmonic au nanodisks realized by nanoimprint lithography,” ACS nano, vol. 5, no. 2, pp. 897–904, 2011. [88] R. H. Sagor, M. F. Hassan, A. A. Yaseer, E. Surid, and M. I. Ahmed, “Highly sensitive refractive index sensor optimized for blood group sensing utilizing the fano resonance,” Applied Nanoscience, pp. 1–14, 2020. 83 [89] Z. Zhang, J. Yang, X. He, J. Zhang, J. Huang, D. Chen, and Y. Han, “Plasmonic refractive index sensor with high figure of merit based on concentric-rings resonator,” Sensors, vol. 18, no. 1, p. 116, 2018. [90] K. V. Voronin, Y. V. Stebunov, A. A. Voronov, A. V. Arsenin, and V. S. Volkov, “Vertically coupled plasmonic racetrack ring resonator for biosensor applications,” Sensors, vol. 20, no. 1, p. 203, 2020. [91] M. Butt, N. Kazanskiy, and S. Khonina, “Nanodots decorated asymmetric metal–insulator–metal waveguide resonator structure based on fano resonances for refractive index sensing application,” Laser Physics, vol. 30, no. 7, p. 076204, 2020. [92] T.Wu, Y. Liu, Z. Yu, H. Ye, Y. Peng, C. Shu, C. Yang,W. Zhang, and H. He, “A nanometeric temperature sensor based on plasmonic waveguide with an ethanolsealed rectangular cavity,” Optics Communications, vol. 339, pp. 1–6, 2015. [93] J. E. Hall and M. E. Hall, Guyton and Hall textbook of medical physiology e- Book. Elsevier Health Sciences, 2020. [94] K. E. Barrett, S. Boitano, S. M. Barman, and H. L. Brooks, “Ganong’s review of medical physiology twenty,” 2010. [95] M. Amasia and M. Madou, “Large-volume centrifugal microfluidic device for blood plasma separation,” Bioanalysis, vol. 2, no. 10, pp. 1701–1710, 2010. [96] A. W. Mohammad, R. K. Basha, and C. P. Leo, “Nanofiltration of glucose solution containing salts: Effects of membrane characteristics, organic component and salts on retention,” Journal of Food Engineering, vol. 97, no. 4, pp. 510– 518, 2010. [97] X.-L.Wang,W.-N.Wang, and D.-X.Wang, “Experimental investigation on separation performance of nanofiltration membranes for inorganic electrolyte solutions,” Desalination, vol. 145, no. 1-3, pp. 115–122, 2002. [98] N. Branch and R. L. Jones, “Laboratory procedure manual,” 2008. [99] J. Y. Zhang, J. Do,W. R. Premasiri, L. D. Ziegler, and C. M. Klapperich, “Rapid point-of-care concentration of bacteria in a disposable microfluidic device using meniscus dragging effect,” Lab on a Chip, vol. 10, no. 23, pp. 3265–3270, 2010. [100] B. Timmer, K. Van Delft, W. Olthuis, P. Bergveld, and A. van den Berg, “Micro-evaporation electrolyte concentrator,” Sensors and Actuators B: Chemical, vol. 91, no. 1-3, pp. 342–346, 2003. [101] C.-Y. Tan and Y.-X. Huang, “Dependence of refractive index on concentration and temperature in electrolyte solution, polar solution, nonpolar solution, and 84 protein solution,” Journal of Chemical & Engineering Data, vol. 60, no. 10, pp. 2827–2833, 2015. [102] R. R. Singh, S. Kumari, A. Gautam, and V. Priye, “Glucose sensing using slot waveguide-based soi ring resonator,” IEEE Journal of Selected Topics in Quantum Electronics, vol. 25, no. 1, pp. 1–8, 2018. 85
