Assessing the prevalence and impact of leptin receptor (Q223R) polymorphism in Bangladeshi breast cancer patients: a case control study

Abstract

Breast cancer is the leading cause of mortality among women globally, including in Bangladesh, which reports over 13,000 cases annually. This study inquired about the recurrence and impact of the LEPR (Q223R) polymorphism in patients of breast cancer from Bangladesh. The leading purpose of this research is evaluating the repetition of this genetic variation in individuals with breast cancer and healthy controls groups, looking into its probable impact on the likelihood of developing cancer. PCR-RFLP method was utilized to perform genotyping of 10 breast cancer patients and 10 healthy controls. The final outcomes showed that the GG genotype was prevalent in both groups, and no substantial association was detected between the (Q223R) polymorphism and an increased hazard of breast cancer. This study aids in understanding the genetic elements that lead to the onset of breast cancer and emphasizes the necessity for additional studies to inspect the role of the LEPR (Q223R) variant in this subset.