In-Vitro Pharmaceutical Quality Control Testing: A Comparative study of Different Brands of Metformin Tablets Available in Bangladesh

Abstract

The aim of the present study was to evaluate and compare quality of locally branded drug products of Metformin Hydrochloride available in Bangladesh with each other. Three different brands of Metformin Hydrochloride tablets available in Bangladesh (Glunor, Daomin and Oramet) were collected from a reputed pharmacy store. The quality control parameters including weight variation, hardness, friability, disintegration test, dissolution test and potency test were performed to evaluate the tablets and to get a comparison between these marketed products. The specification about the drug was followed strictly as given in the USP and BP. For Daomin, Weight varition rage was from 1.9692 to -2.1569, Friability was 0.2496%, Average hardness was 4.19 kg/cm, Disintegration time was 7.5 miniutes, Dissolution(after 45min) was 88.68%, Potency was 93.8%. For Oramet, Weight variation range was from 1.5091 to -1.1644, Friability was 0.3746%, Average hardness was 4.40 kg/cm, Disintegration time was 6.3 minutes, Dissolution(after 45 min) was 85.97%, Potency was 101.2%. For Glunor, Weight variation range was from 1.3202 to -1.0557, Friability was 0.3300%, Average hardness was 4.18 kg/cm, Disintegration time was 9.8 minutes, Dissolution(after 45 min) was 92.22%, Potency was 92.2%. Various results were obtained from the test and compared with the specification. All the tablets met the specification and, hence, it can be concluded that the tablets of the local brands had the desired and optimum therapeutic efficacy.