Comparison of in Vitro Release Kinetics Between Ventolin® and Brodil®

Abstract

Purpose: The purpose of this research work was to compare between the release patterns of Vento lin and Brodil tablets. Method: Ten tablets of each of Vento lin (from GlaxoSmith Kline Pharmaceuticals Ltd.) and Brodil (ACI Pharmaceuticals Ltd.) were collected from the market and were justified by physical parameters like hardness, thickness, weight variation, friability and dissolution studies. Release kinetics was measured by using the method inscribed in British Pharmacopoeia. Hardness of the samples from the market was measured by hardness tester. Thickness of the samples was measured by Vernier Calipers. Dissolution of the taken samples was investigated using dissolution tester (RC6, Vanguard Pharmaceuticals, and USA) to evaluate release kinetics. Result: Mean hardness value of Ventolin and Brodil tablets was found to be 11.64N and 14.72 N, respectively. Mean thickness value of Ventolin and Brodil tablets was found to be 8.42 mm and 9.77 mm respectively. Percentage difference ofthe weight variation test ranges from -2.20% to 3.27 % for Ventolin and-2.40% to 3.44% for Brodil. % friability of Ventolin was found to be 0.17 and of Brodil was found to be - 0.14. Conclusion: The release pattern of Ventolin tablet meet the requirement to not provide desired and optimum therapeutic efficacy, which is ensured by release kinetics of Brodil.