A Study of CNS Depressant Activity of Methanol Extract of Stereospermum chelonoides Leaves

Abstract

Recently worldwide different researches on medicinal plants are holding attention. A number of experiments were found where medicinal plants have been used for different complementary and traditional systems to promote newer and safer drugs. Keep this in mind our current study was designed to find out CNS depressant activity from methanol extracts of leaves of Stereospermumchelonoides. In our present study, we have checked above mentioned pharmacological activities of our experimental plant extracts in mice. By the open-field and hole-board method, CNS depressant activity was inspected with the decline of locomotor activity on mice. Here crude extracts were administered to mice at a dose of 250mg/kg and 500mg/kg. All the results of our experiments were statistically significant (p<0.05, p<0.01, p<0.001). In CNS depressant activity tests, the movement of mice decreased in a dose depending manner comparing to the standard diazepam. In conclusion we can say that our present findings suggest that methanol extracts of Stereospermumchelonoides leaves contain potent CNS depressant principles. It can also be said that the obtained results provide a support for the use of this plant in traditional medicine and its further investigation.