Nanoparticle based targeted drug delivery in ovarian cancer therapy using chemotherapeutic drugs

Abstract

Ovarian cancer is one of the most fatal gynecologic malignancies owing to delayed diagnosis, systemic toxicity as well as drug resistance associated with conventional chemotherapy. This study investigates the potential of nanoparticle based targeted drug delivery systems to enhance the therapeutic efficacy of chemotherapeutic agents namely cisplatin, doxorubicin and paclitaxel. A literature predicted review was conducted using PubMed, Science Direct and Google Scholar to explore the recent advances in nanoparticle formulations and applications in ovarian carcinoma treatment. Findings reveal that nanoparticles improve drug solubility, stability as well as bioavailability while lowering toxicity and reducing multidrug resistance through targeted drug delivery. Liposomes, polymeric particles and metallic nanoparticles show enhanced drug accumulation at tumor sites via improved permeability and retention effects. In general nanoparticle mediated drug delivery systems exhibit significant promise in increasing treatment effectiveness as well as patient compliance while minimizing adverse drug effects in ovarian cancer therapy.