Impact of Different Supplement Drugs on the Dissolution Profile of Zantac and Xantid

Abstract

The work was proposed to determine the impact of different supplements on the dissolution profile of Ranitidine (H2 receptor blocker). Here two brands of Ranitidine tablets were used, Zantac (GlasoSmithKine) and Xantid (ACI). The supplements used in this research work are Calbo 500 (Calcium Supplement), Aristcal-D (Calcium and vitamin D supplement), Acical-M (Calcium, vitamin D and Multimineral supplement), Nutrum Gold (Multivitamin and Multimineral supplement), Filwel Silver (Multivitamin and Multimineral supplement). UV Spectroscopy method was used. Distilled water was used as the dissolution medium. Dissolution tests were run for an hour and the samples were taken and diluted after 20, 40, 60 minutes and absorbance of the diluted samples were taken, by putting the value of the absorbance in the equation of the standard curve percent dissolved amount of the tablets were calculated. After an hour the percent dissolved amount of individual Zantac, Zantac with Calbo 500, Zantac with Aristocal D, Zantac with Acical-M, Zantac with Nutrum Gold and Zantac with Filwel Silver were 94.09%, 47.84%, 72.6%, 48.47%, 94.27% and 97.22% respectively. After an hour the percent dissolved amount of individual Xantid, Xantid with Calbo 500, Xantid with Aristocal D, Xantid with Acical-M, Xantid with Nutrum Gold and Xantid with Filwel Silver were 96.47%, 49.22%, 72.89%, 48.84%, 97% and 98.38% respectively. From the result it was assumed that Calbo 500 and Acical-M has extreme effect, Aristocal D has moderate effect and Nutrum Gold and Filwel Silver has no effect on the dissolution of Zantac and Xantid. Therefore, absorbance and bioavailability of the drug can be affected in the presence of Calbo 500, Aristocal D and Acical-M. So these there supplements can not be coadministered with Zantac and Xantid. Nutrum Gold and Filwel Silver can be coadministered as these supplements has no effect on the dissolution.