Performance evaluation of different brands of pantoprazole tablets

Abstract

Abstract Pantoprazole is a widely produced and marketed drug by many Pharmaceutical companies in Bangladesh. This study is done to compare the evaluation parameter (friability, weight variation, assay, disintegration and dissolution) of enteric coated Pantoprazole tablets. Different brands of Pantoprazole tablets of top, middle and lower listed company were collected from retail pharmacy of Bangladesh Market for their evaluation test. Specified method of USP is followed for their evaluation test. RSD value of weight variation of different drugs is in the range of (0.78-1.65)%, maximum friability of the tablets of all brands is 0.4%, maximum disintegration time in phosphate buffer is 17.42 minutes, Maximum average potency among the brands is 98.14 % and minimum potency is 94.60%, among the brands the maximum drug release in 0.1N HCl is 6.06 , minimum dissolution in phosphate buffer after 45 minutes is 79.94% and the maximum is 88.03%. The result of friability, weight variation, and assay and disintegration tests of all marketed products comply with pharmacopoeial limit except some parameter in case of lower listed company. This study is done to view the scenario of the quality of different brands of Pantoprazole tablets in Bangladesh market.