Solubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent

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dc.contributor.advisorAfrose, Afrina
dc.contributor.advisorDepartment of Pharmacy, Brac University
dc.contributor.authorHossain, Rubaiya
dc.date.accessioned2020-08-08T14:02:06Z
dc.date.available2020-08-08T14:02:06Z
dc.date.issued2019-08
dc.descriptionThis thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
dc.descriptionCataloged from PDF version of thesis report.
dc.descriptionIncludes bibliographical references (pages 46-56).
dc.description.abstractIbuprofen is a drug with very poor aqueous solubility and high permeability. Its poor aqueous solubility is one of the major problems when formulating a dosage form with it. This study was conducted by considering its poor aqueous solubility and solely concentrated on increasing the solubility. In this study the solubility of ibuprofen was examined by dissolution method using water, 10% ethanol and 20% ethanol as solvents. Poloxamer 407 and L-leucine were used as excipients. The whole study was conducted at 25ºC. Ibuprofen was found to show a significant enhancement in solubility in addition with poloxamer 407 in three of the solvent system up to a certain poloxamer 407 concentration (2%). L-leucine did not affect the solubility of ibuprofen significantly, the increment in the solubility were irregular.
dc.identifier.otherID 15146089
dc.identifier.otherhttps://dspace.bracu.ac.bd/server/api/core/items/c5c87036-d5fd-4fb3-8b87-bf685e2cace2
dc.identifier.urihttp://hdl.handle.net/10361/13924
dc.language.isoen
dc.publisherBRAC University
dc.sourceBRAC University Institutional Repository
dc.subjectPoloxamer 407
dc.subjectL-leucine
dc.subjectSolubility
dc.titleSolubility of Ibuprofen with Poloxamer 407 and L-leucine in water and ethanol co-solvent
dc.typeThesis

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