In vivo antidiarrheal activity of Nypa fruticans wurmb fruit pulp

Abstract

Nypa fruticans wurmb has long been utilized in traditional medicine to treat a variety of illnesses including diarrhea. The study was conducted to evaluate antidiarrheal property of the methanolic fruit pulp extract of N. fruticans (NFS). The antidiarrheal activity of NFS extract tested in an experimental model (Swiss albino mice) of castor oil induced diarrhea in 3 different doses- 200, 400 and 600 mg/kg. A significant (p<0.5) reduction in the frequency of wet stools and delaying the onset of diarrhea as compared with the control group were observed in rodents treated with the methanolic crude extract at doses 400 and 600 mg/kg. However, the effect of increased dose dependently and 600 mg/kg NFS extract produced a comparable effect (66.68%) with the reference drug (Loperamide) in mice. Therefore our result proved that N. fruticans (NFS) has potent antidiarrheal activity. Moreover the investigation's promising findings may provide a framework for further study in this area.