The role of COVID-19 induced oxidative stress and inflammation on multiple organ system damage

Abstract

Numerous attempts are being taken globally to comprehend the molecular mechanisms underlying the coronavirus disease 2019 or COVID-19. The majority of deaths among patients might be a direct result of SARS-CoV-2 infection, as many studies suggest a connection between COVID-19-induced oxidative stress and inflammation with multiple organ system damages. To develop treatments for SARS-CoV-2 infected patients, it is currently clinically critical to infer how oxidative stress and molecular inflammatory pathways drive COVID-19 propagation to extreme phenotypes including neurological disorders, cardiac damage, pulmonary dysfunction, etc. This research reviews the molecular pathophysiology of SARS-CoV-2 and how it relates to oxidative stress and inflammation-induced organ damage to the heart, liver, kidney, brain, lungs, and other major organs, as well as the development of cancer. A summary of potential antioxidant treatments that might prevent or minimize the severity of the disease is also discussed.