Pharmacological Studies of Methanolic Extract of Glycosmis pentaphylla

Abstract

Purpose: The research work was carried out to determine the pharmacological activities of methanolic extract of Glycosmis pentaphylla. Method: Methanolic extract was administered orally to the animal model (Swiss albino) and the effects were determined by comparing with respect to control group which were treated with 5% CMC. For every experiment, positive control was used. Different experiments were used to determine the pharmacological profile which was collected from the internationally published publications and journals. Result: The CNS activity was evaluated by open field method and hole board test. In the open field method and hole board experiment, the crude extract of Glycosmis pentaphylla (200mg/kg, 400mg/kg and 800mg/kg) dose dependently reduces the number of peripheral locomotion, central locomotion and leaning in the open field test and reduces the number of head dipping and head poking in the hole board test. The reduction is significant when it is compared to the standard drug. The aim of the study was also to investigate the possible toxicity of the plant Glycosmis pentaphylla and especially to establish the safety of the methanolic extract of this plant by focusing on its chronic toxicity in mice. For finding chronic toxicity several tests were done such as CBC (Cell Blood count) test and Liver Function test. All data were analyzed by using SPSS analytical method. Conclusion: After summarizing all the results, it can be said that Glycosmis pentaphylla may have several pharmacological activities but to prove the hypothesis, further higher studies are needed to be conducted.