Evaluation of neuro-pharmacological effects of calabash chalk on Swiss albino Mice

Abstract

In some countries in Asia and Africa, calabash chalk consumption is common which creates safety concerns. The study aims to evaluate the neuro-pharmacological effect of this chalk in mice. Twenty-four female Swiss albino mice weighing 22-28 grams were taken and were randomly divided into 4 groups. The chalk were ingested by oral gavage at the doses of 200, 400 and 600 mg/Kg/day. A control group was treated with distilled water. Four neuro- pharmacological tests were performed. These were: OFT (Open Field Test), EPM (Elevated Plus Maze), HCT (Hole Cross Test), HBT (Hole Board Test). The results showed that there has been a decrease in the locomotor activity and exploratory behavior. It indicates a probable impairment at a neuromuscular level due to a reduction of locomotive activities as a result of calabash chalk consumption. Therefore, necessary caution must be taken while consuming calabash chalk.