Browsing by Author "Zaeem, Muhammad"

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Pyroptosis: in Diabetic Nephropathy
(Clinica Chimica Acta, Elsevier, 2021-12) Mamun, Abdullah Al; Mimi, Anjuman Ara; Wu, Yanqing; Zaeem, Muhammad; Aziz, Md. Abdul; Suchi, Suzia Aktar; Alyafeai, Eman; Munir, Fahad; Xiao, Jian
Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro-inflammatory cell death featured by gasdermin D (GSDMD)-stimulated plasma membrane pore generation, cell expansion and rapid lysis with the extensive secretion of pro-inflammatory factors, including interleukin-1β (IL-1β) and −18 (IL-18) may be involved in DN. Caspase-1-induced canonical and caspase-4/5/11-induced non-canonical inflammasome-signaling pathways are mainly believed to participate in pyroptosis-mediated cell death. Further research has uncovered that activation of the caspase-3/8 signaling pathway may also activate pyroptosis. Accumulating evidence has shown that NLRP3 inflammasome activation plays a critical role in promoting the pathogenesis of DN. In addition, current studies have suggested that pyroptosis-induced cell death promotes several diabetic complications that include DN. Our present study briefs the cellular mechanisms of pyroptosis-related signaling pathways and their impact on the promotion of DN. In this review, several investigational compounds suppressing pyroptosis-mediated cell death are explored as promising therapeutics in DN.
Role of Pyroptosis in Cancer and Its Therapeutic Regulation
(European Journal of Pharmacology, Elsevier, 2021-11-05) Al Mamun, Abdullah; Mimi, Anjuman Ara; Aziz, Md. Abdul; Zaeem, Muhammad; Ahmed, Tanvir; Munir, Fahad; Xiao, Jian
Pyroptosis is mainly considered a gasdermin-regulated cell death mechanism characterized by cellular lysis and the release of several pro-inflammatory factors. Nowadays, pyro ptosis has notably been gained extensive attention from clinicians and researchers. However, current studies report that down regulation of pyro ptosis-mediated cell death plays a significant role in developing multiple cancers. Increasing studies also suggest that pyro ptosis can impact all stages of carcinogenesis. Inducing pyrophoric cellular death could be a promising therapeutic option for managing and regulating multiple cancers in the near future. Our current review highlights the molecular and morphological features of pyro ptosis and its potential roles in various cancers. In addition, we have also highlighted the biological characteristics and significances of GSDMD and GSDME and their critical functions in cancer progression, management and regulation.
Role of Pyroptosis in Diabetic Retinopathy and Its Therapeutic Implications
(European Journal of Pharmacology, Elsevier, 2021-08-05) Al Mamun, Abdullah; Mimi, Anjuman Ara; Zaeem, Muhammad; Wu, Yanqing; Monalisa, Ilma; Akter, Afroza; Munir, Fahad; Xiao, Jian
Pyro ptosis has recently been established as a term of programmed-inflammatory cell death. Pyro ptosis is mainly divided into two molecular signaling pathways, including caspase-1-dependent canonical and caspase-4/5/11-dependent non-canonical inflammasome pathways. Extensive investigations have reported inflammasome activation facilitates the maturation and secretion of the inflammatory factors interleukin-1β/18 (IL-1β/18), cleavage of gasdermin D (GSDMD), and leading to the stimulation of pyro ptosis-mediated cell death. Furthermore, accumulating studies report NLRP3 inflammasome activation plays a significant role in triggering the pyro ptosis-mediated cell death and promotes the pathogenesis of diabetic retinopathy (DR). Our current review elaborates on the molecular mechanisms of pyro ptosis-signaling pathways and their potential roles in the pathogenesis and impact of DR development. We also emphasize several investigational molecules regulating key steps in pyroptotic-cell death to create new comprehensions and findings to explore the pathogenesis of DR advancement. Our narrative review concisely suggests these potential pharmacological agents could be promising therapies to treat and manage DR in the future.