Browsing by Author "Tirth, Vineet"

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    Nanomaterials: A Promising Therapeutic Approach for Cardiovascular Diseases
    (Daffodil International University, 2022-02-13) Chopra, Hitesh; Bibi, Shabana; Mishra, Awdhesh Kumar; Tirth, Vineet; Yerramsetty, Sree Vandana; Murali, Sree Varshini; Ahmad, Syed Umair; Mohanta, Yugal Kishore; Attia, Mohamed S.; Algahtani, Ali; Islam, Fahadul; Hayee, Abdul; Islam, Saiful; Baig, Atif Amin; Emran, Talha Bin
    Cardiovascular diseases (CVDs) are a primary cause of death globally. A few classic and hybrid treatments exist to treat CVDs. However, they lack in both safety and effectiveness. Thus, innovative nanomaterials for disease diagnosis and treatment are urgently required. The tiny size of nanomaterials allows them to reach more areas of the heart and arteries, making them ideal for CVDs. Atherosclerosis causes arterial stenosis and reduced blood flow. The most common treatment is medication and surgery to stabilize the disease. Nanotechnologies are crucial in treating vascular disease. Nanomaterials may be able to deliver medications to lesion sites after being infused into the circulation. Newer point-of-care devices have also been considered together with nanomaterials. For example, this study will look at the use of nanomaterials in imaging, diagnosing, and treating CVDs.
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    Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract
    (Daffodil International University, 2022-03-28) Islam, Fahadul; Mitra, Saikat; Nafady, Mohamed H.; Rahman, Mohammad Tauhidur; Tirth, Vineet; Akter, Aklima; Emran, Talha Bin; Mohamed, Amany Abdel-Rahman; Algahtani, Ali; El-Kholy, Sanad S.
    The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models. This study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. The experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. The hole-board test extract also demonstrated a reduced number of head dips. The findings showed that L. coromandelica has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research.