Browsing by Author "Shah, Muddaser"

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Multifaceted Role of Natural Sources for COVID-19 Pandemic As Marine Drugs
(Daffodil International University, 2022-05-26) Rahman, Md. Mominur; Islam, Md. Rezaul; Shohag, Sheikh; Hossain, Md. Emon; Shah, Muddaser; shuvo, Shakil khan; Khan, Hosneara; Chowdhury, Md. Arifur Rahman; Bulbul, Israt Jahan; Hossain, Md. Sarowar; Sultana, Sharifa; Ahmed, Muniruddin; Akhtar, Muhammad Furqan; Saleem, Ammara; Rahman, Md. Habibur
COVID-19, which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread over the world, posing a global health concern. The ongoing epidemic has necessitated the development of novel drugs and potential therapies for patients infected with SARS-CoV-2. Advances in vaccination and medication development, no preventative vaccinations, or viable therapeutics against SARS-CoV-2 infection have been developed to date. As a result, additional research is needed in order to find a long-term solution to this devastating condition. Clinical studies are being conducted to determine the efficacy of bioactive compounds retrieved or synthesized from marine species starting material. The present study focuses on the anti-SARS-CoV-2 potential of marine-derived phytochemicals, which has been investigated utilizing in in silico, in vitro, and in vivo models to determine their effectiveness. Marine-derived biologically active substances, such as flavonoids, tannins, alkaloids, terpenoids, peptides, lectins, polysaccharides, and lipids, can affect SARS-CoV-2 during the viral particle’s penetration and entry into the cell, replication of the viral nucleic acid, and virion release from the cell; they can also act on the host’s cellular targets. COVID-19 has been proven to be resistant to several contaminants produced from marine resources. This paper gives an overview and summary of the various marine resources as marine drugs and their potential for treating SARS-CoV-2. We discussed at numerous natural compounds as marine drugs generated from natural sources for treating COVID-19 and controlling the current pandemic scenario.
Retraction Note: Multifaceted Role of Natural Sources for Covid-19 Pandemic as Marine Drugs (Environmental Science and Pollution Research, (2022), 29, 31, (46527-46550), 10.1007/S11356-022-20328-5)
(Springer Nature, 2024-03-14) Rahman, Md. Mominur; Shohag, Sheikh; Hossain, Md. Emon; Shah, Muddaser; Khuvo, Shakil Khan; Khan, Hosneara; Chowdhury, Md. Arifur Rahman; Bulbul, Israt Jahan; Hossain, Md. Sarowar; Sultana, Sharifa; Ahmed, Muniruddin; Akhtar, Muhammad Furqan; Saleem, Ammara; Rahman, Md. Habibur
COVID-19, which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread over the world, posing a global health concern. The ongoing epidemic has necessitated the development of novel drugs and potential therapies for patients infected with SARS-CoV-2. Advances in vaccination and medication development, no preventative vaccinations, or viable therapeutics against SARS-CoV-2 infection have been developed to date. As a result, additional research is needed in order to find a long-term solution to this devastating condition. Clinical studies are being conducted to determine the efficacy of bioactive compounds retrieved or synthesized from marine species starting material. The present study focuses on the anti-SARS-CoV-2 potential of marine-derived phytochemicals, which has been investigated utilizing in in silico, in vitro, and in vivo models to determine their effectiveness. Marine-derived biologically active substances, such as flavonoids, tannins, alkaloids, terpenoids, peptides, lectins, polysaccharides, and lipids, can affect SARS-CoV-2 during the viral particle’s penetration and entry into the cell, replication of the viral nucleic acid, and virion release from the cell; they can also act on the host’s cellular targets. COVID-19 has been proven to be resistant to several contaminants produced from marine resources. This paper gives an overview and summary of the various marine resources as marine drugs and their potential for treating SARS-CoV-2. We discussed at numerous natural compounds as marine drugs generated from natural sources for treating COVID-19 and controlling the current pandemic scenario.
Seasonal Variations of Fine Root Dynamics in Rubber-Flemingia Macrophylla Intercropping System in Southwestern China
(Scopus, 22-10-12) Bibi, Farkhanda; Balasubramanian, Durairaj; Ilyas, Muhammad; Sher, Jan; Hamz Ali, Samoon; Hayder Bin Khalid, Muhammad; Alharby, Hesham F.; Majrashi, Ali; Alghamdi, Sameera A.; Hakeem, Khalid Rehman; Shah, Muddaser
Intercropping cover crops with trees enhance land productivity and improves the soil’s physio-chemical properties while reducing the negative environmental impact. However, there is a lack of quantitative information on the relationships between fine root biomass and available soil nutrients, e.g., nitrogen (N), phosphorus (P), and potassium (K), especially in the rubber-Flemingia macrophylla intercropping system. Therefore, this study was initiated to explore the seasonal variation in fine root biomass and available soil nutrients at different stand ages (12, 15, and 24 years) and management systems, i.e., rubber monoculture (mono) and rubber-Flemingia macrophylla intercrop- ping. In this study, we sampled 900 soil cores over five seasonal intervals, representing one year of biomass. The results showed that the total fine root biomass was greater in 12-year-old rubber monoculture; the same trend was observed in soil nutrients P and K. Furthermore, total fine root biomass had a significant positive correlation with available N (p < 0.001) in rubber monoculture and intercropping systems. Thus, it suggests that fine root growth and accumulation is a function of available soil nutrients. Our results indicate that fine root biomass and soil nutrients (P and K) may be determined by the functional characteristics of dominant tree species rather than collective mixed-species intercropping and are closely linked to forest stand type, topographic and edaphic factors. However, further investigations are needed to understand interspecific and complementary interactions between intercrop species under the rubber-Flemingia macrophylla intercropping system.
The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders
(Molecules, 2021-11-24) Tagde, Priti; Tagde, Pooja; Islam, Fahadul; Tagde, Sandeep; Shah, Muddaser; Hussain, Zareen Delawar; Rahman, Md. Habibur; Najda, Agnieszka; Alanazi, Ibtesam S.; Germoush, Mousa O.; Mohamed, Hanan R. H.; Algandaby, Mardi M.; Nasrullah, Mohammed Z.; Kot, Natalia; Abdel-Daim, Mohamed M.
Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin’s bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin.