Browsing by Author "Semwal, Prabhakar"

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Corrigendum to “exploring the Nutritional and Health Benefits of Pulses from the Indian Himalayan Region: A Glimpse into the Region's Rich Agricultural Heritage” [Food Chem. 422 (2023) 136259] (Food Chemistry (2023) 422, (S0308814623008774), (10.1016/J.Foodchem.2023.136259))
(Elsevier, 2024-03-01) Semwal, Prabhakar; Painuli, Sakshi; Begum, J.P. Shabaaz; Jamloki, Abhishek; Rauf, Abdur; Olatunde, Ahmed; Rahman, Md. Mominur; Mukerjee, Nobendu; Khalil, Anees Ahmed; Aljohani, Abdullah S.M.; Abdulmonem, Waleed Al; Simal-Gand, Jesus
The authors regret the errors that appeared in their paper, “Exploring the nutritional and health benefits of pulses from the Indian Himalayan region: A glimpse into the region’s rich agricultural heritage.” The misrepresentation of data in our review was attributed to cross-reference papers, leading to poor citation due to errors already present in those sources (Venkidasamya et al. 2019; and Liu & Xu, 2016). Additionally, a few typographical errors occurred during the manuscript's revision process, which unfortunately went unnoticed during proofreading. This corrigendum is submitted seeking to address and rectify these issues appropriately.
Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives
(Daffodil International University, 2022-05-29) Semwal, Prabhakar; Painuli, Sakshi; Abu-Izneid, Tareq; Rauf, Abdur; Sharma, Anshu; Daştan, Sevgi Durna; Kumar, Manoj; Alshehri, Mohammed M.; Taheri, Yasaman; Das, Rajib; Mitra, Saikat; Emran, Talha Bin; Sharifi-, Javad; Rad, Javad Sharifi-; Calina, Daniela; Cho, William C.
Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro, in vivo, and clinical studies reporting the diosgenin’s pharmacological effects and to discuss the safety issues. Preclinical studies have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical investigations have demonstrated diosgenin’s nontoxic nature and promising benefits on cognitive function and menopause. However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a better knowledge of the diosgenin’s safety profile.
Exploring the Nutritional and Health Benefits of Pulses From the Indian Himalayan Region
(Elsevier, 2023-04-18) Semwal, Prabhakar; Painuli, Sakshi; Begum, Shabaaz; Jamloki, Abhishek; Rauf, Abdur; Olatunde, Ahmed; Md. Mominur Rahman; Mukerjee, Nobendu; Khalil, Anees Ahmed; Aljohani, Abdullah S.M.; Abdulmonem, Waleed Al; Simal-Gandara, Jesus
Pulses have been consumed worldwide for over 10 centuries and are currently among the most widely used foods. They are not economically important, but also nutritionally beneficial as they constitute a good source of protein, fibre, vitamins and minerals such as iron, zinc, folate and magnesium. Pulses, but particularly species such as Macrotyloma uniflorum, Phaseolus vulgaris L., Glycine max L. and Vigna umbellate, are essential ingredients of the local diet in the Indian Himalayan Region (IHR). Consuming pulses can have a favourable effect on cardiovascular health as they improve serum lipid profiles, reduce blood pressure, decrease platelet activity, regulate blood glucose and insulin levels, and reduce inflammation. Although pulses also contain anti-nutritional compounds such as phytates, lectins or enzyme inhibitors, their deleterious effects can be lessened by using effective processing and cooking methods. Despite their great potential, however, the use of some pulses is confined to IHR regions. This comprehensive review discusses the state of the art in available knowledge about various types of pulses grown in IHR in terms of chemical and nutritional properties, health effects, accessibility, and agricultural productivity.
Himalayan Wild Fruits as a Strong Source of Nutraceuticals, Therapeutics, Food and Nutrition Security
(Springer Nature, 2022-09-14) Semwal, Prabhakar; Painuli, Sakshi; Jamloki, Abhishek; Rauf, Abdur; Rahman, Md. Mominur; Olatunde, Ahmed; Hemeg, Hassan A.; Abu-Izneid, Tareq; Naz, Saima; Bangar, Sneh Punia; Lorenzo, Jose M.; Simal-Gandara, Jesus
The Himalayan region supports a wide diversity of flora and fauna; hence it is home to many natural resources. Despite this, the people living here are struggling for essential needs such as food and nutrition. However, in Himalayan region, wild plants and their fruits contribute significantly to the livelihood of local people and communities. Several studies recommended that Himalayan wild fruits possess significant biologically active compounds, antioxidants, vitamins and minerals. In addition, the presence of secondary metabolites in these plants gives them a prominent place in traditional medicinal systems. However, detailed investigation of health-promoting effects, chemical composition, and nutraceutical profiling is lacking in the variety of Himalayan wild fruits. Therefore, this review article will explore the information about wild edible fruits, such as health-promoting effects, chemical composition, and nutraceutical profiling in the Himalayan region. In this context, a detailed search was done through different search engines including Scopus, PubMed, Web of Science, Science Direct and Google Scholar. Specific keywords were used to explore available data about Himalayan wild fruits. Several Himalayan wild fruits like Berberis asiatica, Celtis australis, Ficus palmata, Fragaria indica, Morus alba, Myrica esculenta, Phyllanthus emblica, Prunus armeniaca, etc. showed presence of important bioactive compounds responsible for different therapeutic activities such as anti-inflammatory, anti-diabetic, anticancer, cardioprotective, neuroprotective, antimicrobial, etc. These fruits also possess high nutraceutical value. Hence this study presents detailed information about wild edible fruits which will be helpful in future for researchers, food industries, pharmaceutical industries, and several other government and non-government organisations in developing strategies to ensure food security by using these important wild fruits.
Mechanistic Inhibition of Gastric Cancer-Associated Bacteria Helicobacter pylori by Selected Phytocompounds
(Elsevier, 2023-10-05) Akash, Shopnil; Bayıl, Imren; Mahmood, Sajjat; Mukerjee, Nobendu; Mili, Tamanna Akter; Dhama, Kuldeep; Rahman, Md Anisur; Maitra, Swastika; Mohany, Mohamed; Al-Rejaie, Salim S.; Ali, Nemat; Semwal, Prabhakar; Sharma, Rohit
Background Helicobacter pylori (H. pylori) is a persistent bacterial inhabitant in the stomachs of approximately half the global populace. This bacterium is directly linked to chronic gastritis, leading to a heightened risk of duodenal and gastric ulcer diseases, and is the predominant risk factor for gastric cancer - the second most common cause of cancer-related deaths globally. The increasing prevalence of antibiotic resistance necessitates the exploration of innovative treatment alternatives to mitigate the H. pylori menace. Methods Initiating our study, we curated a list of thirty phytochemicals based on previous literature and subjected them to molecular docking studies. Subsequently, eight phytocompounds—Glabridin, Isoliquiritin, Sanguinarine, Liquiritin, Glycyrrhetic acid, Beta-carotin, Diosgenin, and Sarsasapogenin—were meticulously chosen based on superior binding scores. These were further subjected to an extensive computational analysis encompassing ADMET profiling, drug-likeness evaluation, principal component analysis (PCA), and molecular dynamic simulations (MDs) in comparison with the conventional drug, Mitomycin. Results The natural compounds investigated demonstrated superior docking affinities to H. pylori targets compared to the standard Mitomycin. Notably, the phytocompounds Diosgenin and Sarsasapogenin stood out due to their exceptional binding affinities and pharmacokinetic properties, including favorable ADMET profiles. Conclusion Our comprehensive and technologically-advanced approach showcases the potential of identified phytocompounds as pioneering therapeutic agents against H. pylori-induced gastric malignancies. In light of our promising in silico results, we recommend these natural compounds as potential candidates for advancing H. pylori-targeted drug development. Given their potential, we strongly advocate for subsequent in vitro and in vivo studies to validate their therapeutic efficacy against this formidable gastrointestinal bacterium.
Neuroinflammatory Markers
(Daffodil International University, 2022-05-17) Rauf, Abdur; Badoni, Himani; Abu-Izneid, Tareq; Olatunde, Ahmed; Rahman, Md Mominur; Painuli, Sakshi; Semwal, Prabhakar; Wilairatana, Polrat; S Mubarak, Mohammad
Neuroinflammation, a protective response of the central nervous system (CNS), is associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of neurons and glial cells consisting of microglia, oligodendrocytes, and astrocytes. Entry of any foreign pathogen activates the glial cells (astrocytes and microglia) and overactivation of these cells triggers the release of various neuroinflammatory markers (NMs), such as the tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-1β (IL-10), nitric oxide (NO), and cyclooxygenase-2 (COX-2), among others. Various studies have shown the role of neuroinflammatory markers in the occurrence, diagnosis, and treatment of neurodegenerative diseases. These markers also trigger the formation of various other factors responsible for causing several neuronal diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), ischemia, and several others. This comprehensive review aims to reveal the mechanism of neuroinflammatory markers (NMs), which could cause different neurodegenerative disorders. Important NMs may represent pathophysiologic processes leading to the generation of neurodegenerative diseases. In addition, various molecular alterations related to neurodegenerative diseases are discussed. Identifying these NMs may assist in the early diagnosis and detection of therapeutic targets for treating various neurodegenerative diseases.
The Neuroprotective Potential of Endophytic Fungi and Proposed Molecular Mechanism
(Daffodil International University, 2022-10-01) Semwal, Prabhakar; Painuli, Sakshi; Anand, Jigisha; Martins, Nat´alia Cruz; Machado, Marisa; Sharma, Rohit; Batiha, Gaber El-Saber; Yaro, Clement Amen; Lorenzo, Jose M.; Rahman, Md. Mominur
Millions of people are affected by neuronal disorders that are emerging as a principal cause of death after cancer. Alzheimer’s disease, ataxia, Parkinson’s disease, multiple system atrophy, and autism comprise the most common ones, being accompanied by loss of cognitive power, impaired balance, and movement. In past decades, natural polyphenols obtained from different sources including bacteria, fungi, and plants have been utilized in the traditional system of medicine for the treatment of several ailments. Endophytes are one such natural producer of secondary metabolites, namely, polyphenols, which exhibit strong abilities to assist in the management of such affections, through modifying multiple therapeutic targets and weaken their complex physiology. Limited research has been conducted in detail on bioactive compounds present in the endophytic fungi and their neuroprotective effects. Therefore, this review aims to provide an update on scientific evidences related to the pharmacological and clinical potential along with proposed molecular mechanism of action of endophytes for neuronal protection.