Browsing by Author "Saha, Shuvo"

Now showing 1 - 3 of 3

A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
(Scopus, 22-10-04) Biswas, Partha; Dey, Dipta; Biswas, Polash Kumar; Rahaman, Tanjim Ishraq; Saha, Shuvo; Parvez, Anwar; Khan, Dhrubo Ahmed; Lily, Nusrat Jahan; Saha, Konka; Sohel, Md; Hasan, Mohammad Mehedi; Al Azad, Salauddin; Bibi, Shabana; Hasan, Md. Nazmul; Rahmatullah, Mohammed; Chun, Jaemoo; Rahman, Md. Ataur; Kim, Bonglee
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible for the maintenance of the cancer phenotype; this unique feature in cancer cells may, therefore, be exploited for targeted therapy. Quercetin (QC), a plant-derived bioflavonoid, is known for its ROS scavenging properties and was recently discovered to have various antitumor properties in a variety of solid tumors. Adaptive stress responses may be induced by persistent ROS stress, allowing cancer cells to survive with high levels of ROS while maintaining cellular viability. However, large amounts of ROS make cancer cells extremely susceptible to quercetin, one of the most available dietary flavonoids. Because of the molecular and metabolic distinctions between malignant and normal cells, targeting ROS metabolism might help overcome medication resistance and achieve therapeutic selectivity while having little or no effect on normal cells. The powerful bioactivity and modulatory role of quercetin has prompted extensive research into the chemical, which has identified a number of pathways that potentially work together to prevent cancer, alongside, QC has a great number of evidences to use as a therapeutic agent in cancer stem cells. This current study has broadly demonstrated the function-mechanistic relationship of quercetin and how it regulates ROS generation to kill cancer and cancer stem cells. Here, we have revealed the regulation and production of ROS in normal cells and cancer cells with a certain signaling mechanism. We demonstrated the specific molecular mechanisms of quercetin including MAPK/ERK1/2, p53, JAK/STAT and TRAIL, AMPKα1/ASK1/p38, RAGE/PI3K/AKT/mTOR axis, HMGB1 and NF-κB, Nrf2-induced signaling pathways and certain cell cycle arrest in cancer cell death, and how they regulate the specific cancer signaling pathways as long-searched cancer therapeutics. Keywords: ROS; REDOX imbalance; carcinogenesis; malignant cells; quercetin; cancer stem cells
Implementation of An E-Shopping Website
(Daffodil International University, 2018-11-29) Saha, Shuvo
After the term World Wide Web was instituted in 1990, web application advancement encountered a colossal blast. Static HTML pages developed into dynamic, complex business applications. The Internet has opened up another skyline for exchange and trade, in particular electronic Commerce (web based business). Web based business involves the utilization of the Internet in the showcasing, distinguishing proof, installment and conveyance of merchandise and enterprises. There is no lack of best down research disclosing to us that the ecommerce advertise is tremendous, becoming to a great degree quick, and hinting at no backing off. As per sources like "e Marketer", ecommerce is the main trillion-dollar industry developing at a twofold digit rate every year. What's more, with the US Census Bureau assessing that just 7% of retail deals are done on the web, ecommerce still has a great deal of runway for development. In this project I have created a dynamic E-shopping Website by using modern web development framework and also setup it in a live server for further potential testing and developing. Which can allow us to manage the inventory system, advanced shopping cart system, user management system, shop different products through online payment gateway and lots more dynamic functionality. During this project development process, I have done lots of research on existing Ecommerce web applications and businesses. Which allow me to develop and implement a dynamic E-shopping web application and its business aspects.
Student-teachers' choice of authentic ELT materials for 'teaching practicum' course: a narrative investigation
(BRAC University, 2021-02) Bushra, Samrin Zaman; Saha, Shuvo
Authentic materials are printed messages, visual writings, and sound materials which understudies looked in their homerooms, for example, change-of address structures, employment forms, menus, phone message messages, radio projects, and recordings. In spite of the fact that these materials are not created to teach yet they might be magnificent learning devices for EFL learners to get the practical knowledge of the language usage. Besides, useful materials bring positive outcome for the educators as students can relate effectively with their lesson activities. However selection of such material is not easy and often consumes a lot of time. This paper examines how student-teachers during their teaching practicum course select useful authentic material, what are the factors influence them in the selection, and what and how they overcome the challenges which they face with the selected authentic materials. To conduct the research narrative inquiry method has been used where the participants shared their stories and the data obtained show the factors considered in authentic material selection, challenges with the material and how they have overcome those challenges.