Browsing by Author "Roy, Arpita"

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A Decade's Worth of Impact Dox Loaded Liposomes in Anticancer Activity
(Daffodil International University, 22-11-01) Ghosh, Puja; Tiwari, Himja; Lakkakula, Jaya; Roy, Arpita; Emran, Talha Bin; Rashid, Summya; Alghamdi, Saad; Rajab, Bodour S.; Almehmadi, Mazen; Allahyani, Mamdouh; Aljuaid, Abdulelah; Alsaiari, Ahad Amer; Sharma, Rohit; Babalghith, Ahmad O.
Clinically approved therapeutics associated with cancer are limited to mostly chemotherapy, surgery and radiotherapy in spite of the advancements in the biomedical field. Due to the cardiotoxicity and uncountable side effects brought by the prevailing treatment strategies, demands are growing for targeted drug delivery using nanomaterials. For this the most commonly used drug, doxorubicin (DOX) is encapsulated within several type of nanovesicles to observe their anticancer activity. Among them, DOX encapsulated liposomes gained popularity because of their clinical success and lower toxicity. To enhance their efficiency and site specific delivery, attempts are made to modify the liposomes by combining them with peptides, aptamers, antibodies etc to develop pH, thermal, UV-sensitive and electro-magnetic liposomal nanocarriers for controlled drug release. The novel strategies for the treatment of Breast, Lung, Liver, Pancreatic, Prostate, Ovarian, Cervical, Blood, Brain and Colon cancer using modified liposomes encapsulating DOX are illustrated in this review.
A domain and noise adversarial bird tune classification pipeline using deep neural network
(BRAC University, 9/29/2022) Riya, Aparna Sarker; Roy, Arpita; Fahim, Md. Abrar; Tasnim, Zarin; Islam, Rakibul; Mostakim, Moin; Reza, Md Tanzim
Birds are an important category of animals that ecologists keep track of utilizing autonomous recording units as a key indication of environmental health. Because of the consequences of climate change and the rising number of endangered species, many experts suggested developing an animal species recognition system to help them in specialized research. Researchers can improve their ability to assess the state of biodiversity and its patterns in crucial ecosystems by precise sound detection and categorization, which is supported by machine learning, allowing them to better support global conservation efforts. However, producing analysis outputs with high precision and recall remains a difficulty. Due to a lack of appropriate methods for efficient and accurate extraction of interest signals, the vast bulk of data remains unexplored (e.g., bird calls). Moreover, due to strong source-domain specific features and artificial/natural noises, these acquired raw data create different distributions in datasets. So, to ensure a generalized feature learning, domain adaptation [1] techniques will be implemented in this work to make the networks familiar towards both acquisition sensor noises and background noises without having to do intensive dataset specific augmentations. We used 3 popular and powerful DNN models, including CNN, VGG19 and ResNet50. Out of them, for the bird species classification task VGG19 achieved the best accuracy of 96.02% in testing and 94.01% in training. To the best of our knowledge, this will guide towards convenient and deployable in real life models which will allow future works into the pipeline to ensure better coverage.
Central Composite Designed Fast Dissolving Tablets for Improved Solubility of the Loaded Drug Ondansetron Hydrochloride
(Daffodil International University, 2022-08-21) Thalluri, Chandrashekar; Amin, Ruhul; Mandhadi, Jithendar Reddy; Gacem, Amel; Emran, Talha Bin; Dey, Biplab Kumar; Roy, Arpita; Alqahtani, Mohammed S; Refat, Moamen S.; Safi, Sher Zaman; Alsuhaibani, Amnah Mohammed
Ondansetron tablets that are directly compressed using crospovidone and croscarmellose as a synthetic super disintegrant are the subject of this investigation. A central composite, response surface, randomly quadratic, nonblock (version 13.0.9.0) 32 factorial design is used to optimize the formulation (two-factor three-level). To make things even more complicated, nine different formulation batches (designated as F1-F9) were created. There were three levels of crospovidone and croscarmellose (+1, 0, -1). In addition to that, pre- and postcompressional parameters were evaluated, and all evaluated parameters were found to be within acceptable range. Among all postcompressional parameter dispersion and disintegration time, in vitro drug release experiments (to quantify the amount of medication released from the tablet) and their percentage prediction error were shown to have a significant influence on three dependent variables. Various pre- and postcompression characteristics of each active component were tested in vitro. Bulk density, tap density, angle of repose, Carr's index, and the Hausner ratio were all included in this analysis, as were many others. This tablet's hardness and friability were also assessed along with its dimension and weight variations. Additional stability studies may be conducted using the best batch of the product. For this study, we utilised the Design-Expert software to select the formulation F6, which had dispersion times of 17.67 ± 0.03 seconds, disintegration times of 120.12 ± 0.55 seconds, and percentage drug release measurements of 99.25 ± 0.36 within 30 minutes. Predicted values and experimental data had a strong correlation. Fast dissolving pills of ondansetron hydrochloride may be created by compressing the tablets directly.
Cyclodextrin Nanoparticles for Diagnosis and Potential Cancer Therapy
(Daffodil International University, 22-09-08) Karthic, Anandakrishnan; Roy, Arpita; Lakkakula, Jaya; Alghamdi, Saad; Shakoori, Afnan; Babalghith, Ahmad O.; Emran, Talha Bin; Sharma, Rohit; Lima, Clara Mariana Gonçalves; Kim, Bonglee; Park, Moon Nyeo; Safi, Sher Zaman; Almeida, Ray Silva de; Coutinho, Henrique Douglas Melo
Cancer is still one of the world’s deadliest health concerns. As per latest statistics, lung, breast, liver, prostate, and cervical cancers are reported topmost worldwide. Although chemotherapy is most widely used methodology to treat cancer, poor pharmacokinetic parameters of anticancer drugs render them less effective. Novel nano-drug delivery systems have the caliber to improve the solubility and biocompatibility of various such chemical compounds. In this regard, cyclodextrins (CD), a group of natural nano-oligosaccharide possessing unique physicochemical characteristics has been highly exploited for drug delivery and other pharmaceutical purposes. Their cup-like structure and amphiphilic nature allows better accumulation of drugs, improved solubility, and stability, whereas CDs supramolecular chemical compatibility renders it to be highly receptive to various kinds of functionalization. Therefore combining physical, chemical, and bio-engineering approaches at nanoscale to specifically target the tumor cells can help in maximizing the tumor damage without harming non-malignant cells. Numerous combinations of CD Nano composites were developed over the years, which employed photodynamic, photo thermal therapy, chemotherapy, and hyperthermia methods, particularly targeting cancer cells. In this review, we discuss the vivid roles of cyclodextrin nan composites developed for the treatment and theranostics of most important cancers to highlight its clinical significance and potential as a medical tool.
Cyclodextrin Nanoparticles in Targeted Cancer Theranostics
(Europe Pub Med Central, 2023-08-03) Bose, Roshnee; Jayawant, Maharsh; Raut, Rajesh; Roy, Arpita; Alghamdi, Saad; Qusty, Naeem F.; Sharma, Rohit; Verma, Devvret; Khandaker, Mayeen Uddin; Almujally, Abdullah; Tamam, Nissren; Sulieman, Abdelmoneim
The field of cancer nanotheranostics is rapidly evolving, with cyclodextrin (CD)-based nanoparticles emerging as a promising tool. CDs, serving as nanocarriers, have higher adaptability and demonstrate immense potential in delivering powerful anti-cancer drugs, leading to promising and specific therapeutic outcomes for combating various types of cancer. The unique characteristics of CDs, combined with innovative nanocomplex creation techniques such as encapsulation, enable the development of potential theranostic treatments. The review here focuses mainly on the different techniques administered for effective nanotheranostics applications of CD-associated complex compounds in the domain of cancer treatments. The experimentations on various loaded drugs and their complex conjugates with CDs prove effective in in vivo results. Various cancers can have potential nanotheranostics cures using CDs as nanoparticles along with a highly efficient process of nanocomplex development and a drug delivery system. In conclusion, nanotheranostics holds immense potential for targeted drug delivery and improved therapeutic outcomes, offering a promising avenue for revolutionizing cancer treatments through continuous research and innovative approaches.
Fucoxanthin
(Daffodil International University, 2022-08-02) Das, Ayan; Mumu, Mumtaza; Emran, Talha Bin; Mitra, Saikat; Islam, Fahadul; Roy, Arpita; Karim, Md. Mobarak; Das, Rajib; Park, Moon Nyeo; Chandran, Deepak; Sharma, Rohit; Khandaker, Mayeen Uddin; Idris, Abubakr M.; Kim, Bonglee
Fucoxanthin (FX) is a special carotenoid having an allenic bond in its structure. FX is extracted from a variety of algae and edible seaweeds. It has been proved to contain numerous health benefits and preventive effects against diseases like diabetes, obesity, liver cirrhosis, malignant cancer, etc. Thus, FX can be used as a potent source of both pharmacological and nutritional ingredient to prevent infectious diseases. In this review, we gathered the information regarding the current findings on antimicrobial, antioxidant, anti-inflammatory, skin protective, anti-obesity, antidiabetic, hepatoprotective, and other properties of FX including its bioavailability and stability characteristics. This review aims to assist further biochemical studies in order to develop further pharmaceutical assets and nutritional products in combination with FX and its various metabolites.
Polymer-Based Nanocarriers for Biomedical and Environmental Applications
(De Gruyter, 2023-08-31) Idris, Dahir Sagir; Roy, Arpita; Pandit, Soumya; Alghamdi, Saad; Alsaiari, Ahad Amer; Abdulaziz, Osama; Alsharif, Abdulaziz; Khandaker, Mayeen Uddin; Faruque, Mohammad Rashed Iqbal
Polymer-based nanocarriers are created from natural or synthetic polymers that are modified to form submicroscopic particles. The polymer matrix can be customized to provide specific properties, such as surface chemistry and flexibility. This allows the particles to be designed and used in different fields. They are promising nanomaterials that are used as therapeutic and diagnostic agents, and they have potential biomedical and environmental applications. These nanocarriers are polymers that can be engineered with other types of nanomaterials with different sizes, shapes, and compositions. They can deliver drugs or their cargo to a specific site with precisely controlled release. They have many advantages compared to traditional drug delivery carriers, including improved biocompatibility, reduced toxicity, and increased efficacy. In biomedical applications, polymer nanocarriers have been used as drug delivery carriers, cancer therapy, and gene therapy. In environmental applications, polymer nanocarriers are able to remove heavy metals and other contaminants from air and water bodies. In this review, a summary of recent fabrication, design, synthesis, characterisation, and various applications in the biomedical and environmental fields has been provided. The review also highlights the current challenges and prospects of evolving polymer nanocarriers.
Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts
(Scopus, 22-09-23) Muzammil, Saima; Wang, Yunsheng; Siddique, Muhammad Hussnain; Zubair, Errum; Hayat, Sumreen; Zubair, Muhammad; Roy, Arpita; Mumtaz, Rabia; Azeem, Muhammad; Emran, Talha Bin; Shahid, Muhammad Qasim
Coronopus didymus (Brassicaceae) commonly known as lesser swine cress has been reported to be used for its pharmacological activities. This study aimed to evaluate the medicinal potential of C. didymus extracts against cancer, diabetes, infectious bacteria and oxidative stress and the identification of bioactive compounds present in these extracts. The effects of using different solvents for the extraction of C. didymus on the contents of major polyphenols and biological activities were investigated. Plant sample was shade dried, ground to a fine powder, and then soaked in pure acetone, ethanol and methanol. The highest contents of major polyphenols were found in methanol-based extract, i.e., chlorogenic acid, HB acid, kaempferol, ferulic acid, quercetin and benzoic acid with 305.02, 12.42, 11.5, 23.33, 975.7 and 428 mg/g of dry weight, respectively, followed by ethanol- and acetone-based extracts. The methanol-based extract also resulted in the highest antioxidant activities (56.76%), whereas the highest antiproliferative (76.36) and alpha glucosidase inhabitation (96.65) were demonstrated in ethanol-based extracts. No antibacterial property of C. didymus was observed against all the tested strains of bacteria. Further studies should be focused on the identification of specific bioactive compounds responsible for pharmacological activities.
Possibilities of Medicinal Plants to Treat SARS-CoV-2
(Scopus, 2020) Johora, Umme Fatema Tuj; Hossain, Md. Sakhawat; Sultana, Sharifa; Nizhum, Nisarat; Bhowmick, Aditi; Roy, Arpita; Mondal, Shadhan Kumar; Saha, Tushar
The new Corona-virus, recently called the severe acute respiratory syndrome Coronavirus (SARS-CoV-2) appears for the first time in China and more precisely in Wuhan (December 2019). This infection can be deadly. Seniors, and individuals with other restorative conditions may be more helpless and ended up truly sick. Typically why inquire about into drugs to treat this contamination remains basic in a few investigate laboratories. Natural home grown cures have long been the most, in case not the as it were, cure within the verbal convention for treating sicknesses. Advanced pharmaceutical has known its victory much appreciated to conventional medication, the adequacy of which determines from therapeutic plants. The objective of this think about is to decide in case the components of common root have an anti-viral impact and which can anticipate people from disease by this coronavirus utilizing the foremost dependable strategy is atomic docking, which utilized to discover the interaction between considered atoms and the protein, in our case we based on the inhibitor of Coronavirus (nCoV-2019) primary protease. Chinese Pharmaceutical herbs might be a profitable pool for distinguishing active compounds for treating disease of 2019-nCoV. In this think about, we summarize several dynamic compounds, counting baicalin, Scutellarin, Hesperetin, Nicotianamine and glycyrrhizin that may have potential anti-2019-nCoV effects. We conduct atomic docking to anticipate their capacity for authoritative ACE2, which may anticipate the 2019-nCoV disease. We propose that these chosen compounds worth assist examination for avoiding 2019-nCoV
Prospects of 4d Printing in Pharmaceuticals
(Scopus, 2020) Roy, Arpita; Hossain, Md. Sakhawat; Bhowmick, Aditi; Nizhum, Nisarat; Mondal, Shadhan Kumar; Saha, Tushar
4D printing is a fledgling technology with enormous potential that may bring revolution to the future manufacturing industry along with pharmaceuticals. MIT's Self Assembly Lab and Stratasys education and R&D department first developed this concept jointly in 2013. 3D printing has already proved its competence and achieved wide acceptance after being invented in 1984. 4D printing is an up-gradation of 3D printing technology. 4D printing adopts time as the 4th dimension. It allows the fabrication of stimuli-responsive 3D structures that can independently change its morphology over time. External stimuli such as light, pH, magnetic field, moisture content, etc. can trigger the shape-changing event. 4D printing technology can be applied to develop site-specific, controlled release as well as a customized drug delivery system. Researchers are also optimistic about its application in the biomedical sector. This paper presents a comprehensive review of the basic mechanism of 4D printing technology and its possible future application and prospects in the pharmaceuticals and biomedical fields.
Recent Outbreak of Monkeypox
(Daffodil International University, 22-09-05) Shuvo, Pollob Ahmed; Roy, Arpita; Dhawan, Manish; Chopra, Hitesh; Emran, Talha Bin
Monkeypox virus is an orthopox virus that causes a less severe illness with symptoms similar to smallpox. Monkeypox, which is a zoonotic viral disease, is endemic to West and Central Africa. Two different clades are known, namely The West African clade, with a reported mortality rate of 1%, and the Congo Basin clade, also known as the Central African clade, with a reported mortality rate of 10%. The disease was named "monkeypox" because two outbreaks of diseases were first discovered in 1958 when they occurred in a colony of research monkeys. First human exposure to monkeypox was recorded in the year 1970 when extreme measures for eradication of smallpox were being taken. Then again, smallpox was eradicated in 1980, but monkeypox continues to occur in Central and West African countries from time to time
Sustainable Degradation of Synthetic Plastics: A Solution to Rising Environmental Concerns
(Elsevier, 2024-03-24) Shah, Masirah Zahid; Quraishi, Marzuqa; Sreejith, Anushree; Pandit, Soumya; Roy, Arpita; Khandaker, Mayeen Uddin
Plastics have a significant role in various sectors of the global economy since they are widely utilized in agriculture, architecture, and construction, as well as health and consumer goods. They play a crucial role in several industries as they are utilized in the production of diverse things such as defense materials, sanitary wares, tiles, plastic bottles, artificial leather, and various other household goods. Plastics are utilized in the packaging of food items, medications, detergents, and cosmetics. The overconsumption of plastics presents a significant peril to both the ecosystem and human existence on Earth. The accumulation of plastics on land and in the sea has sparked interest in finding ways to breakdown these polymers. It is necessary to employ suitable biodegradable techniques to decrease the accumulation of plastics in the environment. To address the environmental issues related to plastics, it is crucial to have a comprehensive understanding of the interaction between microorganisms and polymers. A wide range of creatures, particularly microbes, have developed techniques to survive and break down plastics. This review specifically examines the categorization of plastics based on their thermal and biodegradable properties, as well as the many types of degradation and biodegradation. It also discusses the various types of degradable plastics, the characterization of biodegradation, and the factors that influence the process of biodegradation. The plastic breakdown and bioremediation capabilities of these microbes make them ideal for green chemistry applications aimed at removing hazardous polymers from the ecosystem.
Thiazolidin-2,4-Dione Scaffold: An Insight Into Recent Advances As Antimicrobial, Antioxidant, and Hypoglycemic Agents
(Scopus, 22-10-10) Kumar, Harsh; Aggarwal, Navidha; Marwaha, Minakshi Gupta; Deep, Aakash; Chopra, Hitesh; Matin, Mohammed M.; Roy, Arpita; Emran, Talha Bin; Mohanta, Yugal Kishore; Ahmed, Ramzan; Mohanta, Tapan Kumar; Saravanan, Muthupandian; Marwaha, Rakesh Kumar; Al-Harrasi, Ahmed
Heterocyclic compounds containing nitrogen and sulfur, especially those in the thiazole family, have generated special interest in terms of their synthetic chemistry, which is attributable to their ubiquitous existence in pharmacologically dynamic natural products and also as overwhelm- ingly powerful agrochemicals and pharmaceuticals. The thiazolidin-2,4-dione (TZD) moiety plays a central role in the biological functioning of several essential molecules. The availability of substi- tutions at the third and fifth positions of the Thiazolidin-2,4-dione (TZD) scaffold makes it a highly utilized and versatile moiety that exhibits a wide range of biological activities. TZD analogues exhibit their hypoglycemic activity by improving insulin resistance through PPAR-γ receptor activation, their antimicrobial action by inhibiting cytoplasmic Mur ligases, and their antioxidant action by scavenging reactive oxygen species (ROS). In this manuscript, an effort has been made to review the research on TZD derivatives as potential antimicrobial, antioxidant, and antihyperglycemic agents from the period from 2010 to the present date, along with their molecular mechanisms and the information on patents granted to TZD analogues.
Unani Formulation Habb-e-Suranjan
(Daffodil International University, 2024-01-09) Ahemad, Ansari Imtiyaz Ahmed Tufail; Aejazuddin, Qazi Majaz Ahamad; Khan, G. J.; Alsayari, Abdulrhman; Wahab, Shadma; Khan, Sharuk L.; Akter, Noor Jahan; Islam, Md. Rezaul; Roy, Arpita; Islam, Fahadul
Habb-e-Suranjan (HES), an Unani formulation, has been studied for its anti-inflammatory properties in both in vitro and in vivo experiments. HES is recommended for arthritis, gout, and joint pain. The current endeavor is an attempt to put it to the test and verify its efficacy scientifically. It was tested for DPPH, hydroxyl, and nitric oxide scavenging activities. It was shown that HES had the greatest TAC and FRAC values when compared to catechin and ascorbic acid. HES exhibited DPPH and hydroxyl radical scavenging activity that was dose-dependent. Incubation of sodium nitroprusside solutions in PBS at 25°C for 150 min resulted in the production of nitric oxide. Nitric oxide production was effectively decreased by HES. Anti-inflammatory medications boosted the migration of PMN cells toward the chemoattractant FMLP in an agarose experiment of PMN chemotaxis. In carrageenan-induced rat paw edema, in the HES-treated group, paw thickness was 3.021 ± 0.084 at t = 0, but it showed an increase in paw inflammation after one hour, i.e., 3.195 ± 0.082 cm which again showed a decrease in paw thickness up to 4th hour, i.e., 3.018 ± 0.078, 2.98 ± 0.032, and 2.684 ± 0.061 at t = 2, 3, and 4, respectively. It showed again getting back to the normal thickness of paw at t = 24 hrs, i.e., 3.029 ± 0.118 cm. It is concluded that the formulation is potent enough and can be used effectively for the treatment of inflammation and associated health issues. Moreover, there is much scope to evaluate its effectiveness using different in vitro and in vivo models.