Browsing by Author "Rahaman, Md Saidur"

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Bridging the Communication Gap: An AI-Driven word-level Bangla Sign Language Interpreter
(Daffodil International University, 2025-09-16) Rahaman, Md Saidur
The present paper is a research project report creating a real-time Bangla Sign Language (BdSL) recognition system in a two-phase approach. The initial phase concentrated on developing a state-of-the-art baseline with our proposed hybrid Conv1D-BiLSTM architecture including the Attention mechanism with an accuracy of 97.3% on the published 60-word BDSLw60 v2 dataset, which is higher than the previously published benchmarks. The second stage of research was devoted to the important issue of vocabulary development, and a new set of signs of 39 signs, which had been collected by hand, was presented. In order to address the dramatic accuracy drop experienced with first fine-tuning, we designed and adopted a professional quality multi-stage fine-tuning policy that includes class weights and gradual unfreezing. This sophisticated procedure was very practical and the final and strong model reached 93 percent total accuracy in the whole vocabulary (99-word). This last model is implemented on a real-time Flask web application, which translates signs directly to text, showing an end-to-end cycle between a validation of the baseline to a scalable and real-world application.
Emerging Promise of Therapeutic Approaches Targeting Mitochondria in Neurodegenerative Disorders
(Emerald Publishing Limited, 2023-04-12) Rahman, Md Mominur; Tumpa, Mst Afroza Alam; Rahaman, Md Saidur; Islam, Fahadul; Islam, Fahadul; Sutradhar, Popy Rani; Ahmed, Muniruddin; Alghamdi, Badrah S.; Hafeez, Abdul; Alexiou, Athanasios; Perveen, Asma; Ashraf, Ghulam Md
Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain mitochondria are the primary source of fuel that supports many brain functions, including intracellular energy supply, cellular calcium regulation, regulation of limited cellular oxidative capacity, and control of cell death. Much evidence suggests that mitochondria play a central role in neurodegenerative disorders (NDDs) such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis. Ongoing studies of NDDs have revealed that mitochondrial pathology is mainly found in inherited or irregular NDDs and is thought to be associated with the pathophysiological cycle of these disorders. Typical mitochondrial disturbances in NDDs include increased free radical production, decreased ATP synthesis, alterations in mitochondrial permeability, and mitochondrial DNA damage. The main objective of this review is to highlight the basic mitochondrial problems that occur in NDDs and discuss the use mitochondrial drugs, especially mitochondrial antioxidants, mitochondrial permeability transition blockade, and mitochondrial gene therapy, for the treatment and control of NDDs.
Natural Bioactive Molecules
(International Journal of Molecular Sciences, 2021-11-23) Islam, Fahadul; Bibi, Shabana; Meem, Atkia Farzana Khan; Islam, Md Mohaimenul; Rahaman, Md Saidur; Bepary, Sristy; Rahman, Md Mizanur; Rahman, Md Mominur; Elzaki, Amin; Kajoak, Samih; Osman, Hamid; ElSamani, Mohamed; Khandaker, Mayeen Uddin; M Idris, Abubakr; Emran, Talha Bin
Several coronaviruses (CoVs) have been associated with serious health hazards in recent decades, resulting in the deaths of thousands around the globe. The recent coronavirus pandemic has emphasized the importance of discovering novel and effective antiviral medicines as quickly as possible to prevent more loss of human lives. Positive-sense RNA viruses with group spikes protruding from their surfaces and an abnormally large RNA genome enclose CoVs. CoVs have already been related to a range of respiratory infectious diseases possibly fatal to humans, such as MERS, SARS, and the current COVID-19 outbreak. As a result, effective prevention, treatment, and medications against human coronavirus (HCoV) is urgently needed. In recent years, many natural substances have been discovered with a variety of biological significance, including antiviral properties. Throughout this work, we reviewed a wide range of natural substances that interrupt the life cycles for MERS and SARS, as well as their potential application in the treatment of COVID-19.
The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity:
(Daffodil International University, 2022-03-06) Rahman, Md Mominur; Islam, Md Rezaul; Shohag, Sheikh; Hossain, Md Emon; Rahaman, Md Saidur; Islam, Fahadul; Ahmed, Muniruddin; Mitra, Saikat; Khandaker, Mayeen Uddin; Idris, Abubakr M; Chidambaram, Kumarappan; Emran, Talha Bin; Cavalu, Simona
Obesity and diabetes are the most demanding health problems today, and their prevalence, as well as comorbidities, is on the rise all over the world. As time goes on, both are becoming big issues that have a big impact on people's lives. Diabetes is a metabolic and endocrine illness set apart by hyperglycemia and glucose narrow-mindedness because of insulin opposition. Heftiness is a typical, complex, and developing overall wellbeing worry that has for quite some time been connected to significant medical issues in individuals, all things considered. Because of the wide variety and low adverse effects, herbal products are an important hotspot for drug development. Synthetic compounds are not structurally diverse and lack drug-likeness properties. Thus, it is basic to keep on exploring herbal products as possible wellsprings of novel drugs. We conducted this review of the literature by searching Scopus, Science Direct, Elsevier, PubMed, and Web of Science databases. From 1990 until October 2021, research reports, review articles, and original research articles in English are presented. It provides top to bottom data and an examination of plant-inferred compounds that might be utilized against heftiness or potentially hostile to diabetes treatments. Our expanded comprehension of the systems of activity of phytogenic compounds, as an extra examination, could prompt the advancement of remedial methodologies for metabolic diseases. In clinical trials, a huge number of these food kinds or restorative plants, as well as their bioactive compounds, have been shown to be beneficial in the treatment of obesity.