Browsing by Author "Ogaly, Hanan A."

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Molecular insights into withaferin A: A holistic approach to cancer therapy
(2024-12-15) Rezaul Islam, Md.; Abdur Rauf; Rakesh, M. Meenakshi; Akash, Shopnil; Fakir, M. Naeem Hossain; Islam, Samiul; Naba, Afifa Farzana; Al-Imran, Md. Ibrahim Khalil; AlOmar, Taghrid S.; Ogaly, Hanan A.; Alzahrani, Hayat E.; Thiruvengadam, Rekha; Thiruvengadam, Muthu
Withaferin A (WA), a significant phytoconstituent of Withania somnifera, belongs to the triterpenoid class of C28-steroidal lactones found in nature. It has been utilized in traditional and native medical systems to treat various diseases such as cancers. It also has pro-apoptotic, anti-inflammatory, metabolic, and anticancer properties. In addition, it interacts with NF-κB, STAT, Hsp90, ER, and p53, thereby suppressing cancer cell growth and reducing the cell cycle at the G2/M stage. This review discusses the pro-apoptotic properties of WA, such as the generation of ROS, activation of PAR-4, development of ER stress, and activation of p53. This provides a comprehensive analysis of the molecular mechanisms of WA, highlighting its intricate effects on cancer cell signaling pathways, apoptosis, and tumor microenvironment (TME) regulation. Moreover, the ability to modify the TME through immune response modulation underscores its importance in comprehensive cancer treatment. The involvement of WA in oncogenic pathways that lead to malignant neoplasms and its potential therapeutic effects when combined with other cancer treatments are promising. This review indicates that WA's strong pharmacological profile, especially in combating cancer, could be advantageous for developing new cancer therapy medications. Furthermore, it emphasizes the potential of WA as a supplement to standard medications and encourages further clinical trials to assess its efficacy and safety in various cancer types. Moreover, it indicates a growing understanding of natural chemicals in cancer therapy, which can be integrated into various treatment methods.
Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives
(Scopus, 2024-01) Islam, Md. Rezaul; Rauf, Abdur; Akash, Shopnil; Trisha, Sadiya Islam; Nasim, Akram Hossain; Akter, Muniya; Dhar, Puja Sutro; Ogaly, Hanan A.; Hemeg, Hassan A.; Wilairatana, Polrat; Thiruvengadam, Muthu
The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, and depression. Most of these benefits are due to their anti-inflammatory and antioxidant properties. Curcumin consumption leads to decreased bioavailability, resulting in limited absorption, quick metabolism, and quick excretion, which hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with curcumin in a complex. When combined with other enhancing agents, curcumin has a wide spectrum of health benefits. This review evaluates the therapeutic potential of curcumin with a specific emphasis on its approach based on molecular signaling pathways. This study investigated its influence on the progression of cancer, inflammation, and many health-related mechanisms, such as cell proliferation, apoptosis, and metastasis. Curcumin has a significant potential for the prevention and treatment of various diseases. Curcumin modulates several biochemical pathways and targets involved in cancer growth. Despite its limited tissue accumulation and bioavailability when administered orally, curcumin has proven useful. This review provides an in-depth analysis of curcumin's therapeutic applications, its molecular signaling pathway-based approach, and its potential for precision medicine in cancer and human health.
Targeted Therapies of Curcumin Focus on Its Therapeutic Benefits in Cancers and Human Health: Molecular Signaling Pathway-based Approaches and Future Perspectives
(Elsevier, 2024-01-20) Islam, Md. Rezaul; Rauf, Abdur; Akash, Shopnil; Trisha, Sadiya Islam; Nasim, Akram Hossain; Akter, Muniya; Dhar, Puja Sutro; Ogaly, Hanan A.; Hemeg, Hassan A.; Wilairatana, Polrat; Thiruvengadam, Muthu
The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, and depression. Most of these benefits are due to their anti-inflammatory and antioxidant properties. Curcumin consumption leads to decreased bioavailability, resulting in limited absorption, quick metabolism, and quick excretion, which hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with curcumin in a complex. When combined with other enhancing agents, curcumin has a wide spectrum of health benefits. This review evaluates the therapeutic potential of curcumin with a specific emphasis on its approach based on molecular signaling pathways. This study investigated its influence on the progression of cancer, inflammation, and many health-related mechanisms, such as cell proliferation, apoptosis, and metastasis. Curcumin has a significant potential for the prevention and treatment of various diseases. Curcumin modulates several biochemical pathways and targets involved in cancer growth. Despite its limited tissue accumulation and bioavailability when administered orally, curcumin has proven useful. This review provides an in-depth analysis of curcumin's therapeutic applications, its molecular signaling pathway-based approach, and its potential for precision medicine in cancer and human health.