Browsing by Author "Mithi, Faria Mannan"

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Determination the Level of Heavy Metals in Different Edible Fish Species Collected From the Local Market of Dhaka, Bangladesh
(Pharmacology online, 2020-12-30) Raka, Sabreena Chowdhury; Toma, Arofa Ratri; Mithi, Faria Mannan; Rahman, Arifur
The presence of heavy metals was examined in three different fishes, which were collected from a local market in Dhaka, Bangladesh. After drying and crushing, the samples were treated with 70% HNO3+65% HClO4 (4:1), Conc. H2SO4+ conc. HNO3 (mixture need to heat slowly on an oil bath, with the addition of ¾ drops of H2O2), 65% HNO3+30%H2O2 at 80 O C, Tri-acid mixture (HNO3: HClO4: H2SO4= 6:5:6.2) until a clear solution appears. After filtering and dissolving with distilled water solution are analyzed by atomic absorption spectroscopy. The amount of heavy metals means concentrations in the fish muscles expressed Cr (60.22ppb), Cu (51.11ppb), As (5.57ppb), and Zn (1.08ppm) respectively. Heavy metals have the tendency to accumulate in various organs of marine organisms, especially fish which in turn may enter into the human metabolism through consumption causing serious health hazards. The study has shown that Cr was the most and Zn was the least accumulated metal in the studied fish muscles by using the method of AAS analysis. From the human health point of view, this study showed that there are so many possible health risks to consumers due to the intake of studied fishes under the current consumption rate
Multifunctional Therapeutic Potential of Phytocomplexes and Natural Extracts for Antimicrobial Properties
(Antibiotics, 2021) Rahman, Md. Mominur; Rahaman, Md. Saidur; Islam, Md. Rezaul; Hossain, Md. Emon; Mithi, Faria Mannan; Ahmed, Muniruddin; Saldías, Marianela; Akkol, Esra Küpeli; Sobarzo-Sánchez, Eduardo
Natural products have been known for their antimicrobial factors since time immemorial. Infectious diseases are a worldwide burden that have been deteriorating because of the improvement of species impervious to various anti-infection agents. Hence, the distinguishing proof of antimicrobial specialists with high-power dynamic against MDR microorganisms is central to conquer this issue. Successful treatment of infection involves the improvement of new drugs or some common source of novel medications. Numerous naturally occurring antimicrobial agents can be of plant origin, animal origin, microbial origin, etc. Many plant and animal products have antimicrobial activities due to various active principles, secondary metabolites, or phytochemicals like alkaloids, tannins, terpenoids, essential oils, flavonoids, lectins, phagocytic cells, and many other organic constituents. Phytocomplexes’ antimicrobial movement frequently results from a few particles acting in cooperative energy, and the clinical impacts might be because of the direct effects against microorganisms. The restorative plants that may furnish novel medication lead the antimicrobial movement. The purpose of this study is to investigate the antimicrobial properties of the phytocomplexes and natural extracts of the plants that are ordinarily being utilized as conventional medications and then recommended the chance of utilizing them in drugs for the treatment of multiple drug-resistant disease.
Role of Phenolic Compounds in Human Disease
(MDPI, 2021-12-30) Rahman, Md. Mominur; Rahaman, Md. Saidur; Islam, Md. Rezaul; Rahman, Firoza; Mithi, Faria Mannan; Alqahtani, Taha; Almikhlafi, Mohannad A.; Alghamdi, Samia Qasem; Alruwaili, Abdullah S.; Hossain, Md. Sohel; Ahmed, Muniruddin; Das, Rajib; Emran, Talha Bin; Uddin, Md. Sahab
Inflammation is a natural protective mechanism that occurs when the body’s tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit pro-inflammatory mediators’ activity or gene expression, including cyclooxygenase (COX). Various phenolic compounds can also act on transcription factors, such as nuclear factor-κB (NF-κB) or nuclear factor-erythroid factor 2-related factor 2 (Nrf-2), to up-or downregulate elements within the antioxidant response pathways. Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common human ailments, including hypertension, metabolic problems, incendiary infections, and neurodegenerative diseases. The inhibition of the angiotensin-converting enzyme (ACE) by phenolic compounds has been used to treat hypertension. The inhibition of carbohydrate hydrolyzing enzyme represents a type 2 diabetes mellitus therapy, and cholinesterase inhibition has been applied to treat Alzheimer’s disease (AD). Phenolic compounds have also demonstrated anti-inflammatory properties to treat skin diseases, rheumatoid arthritis, and inflammatory bowel disease. Plant extracts and phenolic compounds exert protective effects against oxidative stress and inflammation caused by airborne particulate matter, in addition to a range of anti-inflammatory, anticancer, anti-aging, antibacterial, and antiviral activities. Dietary polyphenols have been used to prevent and treat allergy-related diseases. The chemical and biological contributions of phenolic compounds to cardiovascular disease have also been described. This review summarizes the recent progress delineating the multifunctional roles of phenolic compounds, including their anti-inflammatory properties and the molecular pathways through which they exert anti-inflammatory effects on metabolic disorders. This study also discusses current issues and potential prospects for the therapeutic application of phenolic compounds to various human diseases.