Browsing by Author "Mahmud, Shahin"

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    Analysis of Gene Network Model of Thyroid Disorder and Associated Diseases
    (Informatics in Medicine Unlocked, Science Direct, 2020) Kawsar, Md; Taz, Tasnimul Alam; Paul, Bikash Kumar; Mahmud, Shahin; Islam, Md Manowarul; Bhuyian, Touhid; Ahmed, Kawsar
    Chronic Kidney Disease (CKD), High Blood Pressure (HBP), and Thyroid Disorder (TD) diseases are interrelated. When human patients are affected by one of them, then the possibility of affectness by the other two diseases is increased. Background studies indicate that there are large numbers of similar biological and genetic features among HBP, CKD, and TD. For this reason, the common gene network models among these three diseases are explored. The gene number is reduced through preprocessing and filtering. Then the common genes among the selected diseases and the most significant genes are explored. After completing this process, ten common genes among HBP, CKD, and TD are recognized. This analysis identifies the most significant hub proteins based on biological, biochemical, and genetic relationships between common genes. Following these relationships, the Protein-Protein Interactions network, Co-Expression network, Enrichment Analysis, Topological properties analysis, Gene regulatory network, and Physical Interaction network are exhibited. This analysis helps us to identify similar biological and genetic features among HBP, CKD, and TD. Interaction of proteins with drug molecules enables an efficient drug design for this research. These drugs can be considered for further verification by chemical experiments.
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    Computational Analysis of Network Model Based Relationship of Mental Disorder With Depression
    (Biointerface Research in Applied Chemistry, 2020-05-12) Hasan, Md. Rakibul; Paul, Bikash Kumar; Ahmed, Kawsar; Mahmud, Shahin; Dutta, Mithun; Hosen, Md. Sazib; Hassan, Md. Mehedi; Bhuyian, Touhid
    In this study, we present the network relationship of anxiety, eating and mood disorder with depression. Different computational network models have been demonstrated using different ongoing technologies. One of the most common mental illnesses can be classified as anxiety disorders. These are observable psychological conditions or a category of mental illnesses believed to be caused either by genetic weakness or by causes of environmental sensitivity. A wide range of psychological chronic conditions is often correlated with eating disorders (ED). However, the increasing role of lipid metabolism in ED pathogenesis has been highlighted by recent research studies. Depression (DE) acknowledgement is traced back to the ancient Greeks, who called it melancholia. The word depression has originated with the Greeks who used it to identify a specific condition, a God-given spiritual state, or a response involving rage or excitement, in different ways. Throughout drug research and development, finding innovative mechanisms is a massive challenge. In this field, structure-based design is a basic methodology and has become an essential part of developing drugs. The detailed three-dimensional structure of the protein is shown for a significant number of drug targets. While simulation docking and similar biotechnology have progressed in recent times, a suitable set of docking simulations for simulation performance is difficult to identify.