Browsing by Author "Kumar Paul, Bikash"

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    Exploring Gene Regulatory Networks and Identification of Therapeutic Targets and Potential Drugs with Diseases among PSP, nfvPPA and AD
    (Daffodil International University, 2024-11-24) Bose, Urmi; Rooman, Mehedi Hasan; Md. Noor Hossain, Gazi; Rakibul Hasan, Md.; Kumar Paul, Bikash
    Bioinformatics conceptualizes biological processes to obtain information from biological data in terms of genomics. Background research demonstrates that Progressive supranu-clear palsy (PSP), nonfluent variant primary progressive aphasia (nfvPPA), and Alzheimer's disease (AD) share a significant number of biochemical and genetic characteristics. To conduct this study, we collect GEO (Gene Expression Omnibus), datasets from NCBI. The goal of our research are to identify commonly shared differentially expressed genes (DEGs), PPI network, hub genes, higher degree interactions of micro-RNAs and transcriptional factors from gene regulatory networks(GRN), functional assessment with gene ontology for identifying significant biological functions and signaling pathways for therapeutic targets among PSP, nfvPPA, and Alzheimer's disease (AD). Additionally, this research aims to provide insights for drug design by exploring gene regulatory networks, and protein-drug interactions, contributing to the development of effective treatments.
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    Fiber design and performance analyses for optical multiplexing: terahertz optical communications
    (2024-04-25) Kabir, Md Anowar; Kumar Paul, Bikash; Hossain, Md Selim; Shahin Uddin, Muhammad; Morshed, Monir
    Multiplexing is the process of combining multiple signals at a single channel. Orbital Angular Momentum (OAM) is one of the main multiplexing techniques for optical data transmissions. This paper examines and suggests a hollow core with four layers of semilunar air-hole-shaped circular photonic crystal fiber (PCF) capable of transmitting terahertz (THz) OAM information-carrying modes. By using the full vector finite element method (FEM), OAM multiplexing is analyzed for the proposed fiber. All the THz OAM-based factors are analyzed at a frequency band ranging from 400 GHz to 800 GHz. For the first time, some important PCF factors such as effective refractive index difference (ERID), dispersion profile (DP), OAM purity, confinement loss (CL), effective mode area (ERA), and numerical aperture (NA) are quantitatively discussed with applications. The proposed design supports 50 OAM modes with ERID up to 10−3. The PCF has a CL of approximately 10–10 dB cm−1 and the lowest dispersion profile is 0.3581 ps/THz/cm. Furthermore, the OAM purity is around 97%. Nonetheless, the proposed design can be used in THz-OAM transmission and high optical fiber communications.