Browsing by Author "Kumar, Harsh"

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    An Updated Review on Nanoemulsion: Factory for Food and Drug Delivery
    (Scopus, 2024) Kumar, Virender; Garg, Vandana; Saini, Nakul; Aggarwal, Navidha; Kumar, Harsh; Kumar, Davinder; Chopra, Hitesh; Kamal, Mohammad Amjad; Dureja, Harish
    Background: A nanoemulsion is a colloidal system of small droplets dispersed in another liquid. It has attracted considerable attention due to its unique properties and various applications. Throughout this review, we provide an overview of nanoemulsions and how they can be applied to various applications such as drug delivery, food applications, and pesticide formulations. Objective: This updated review aims to comprehensively overview nanoemulsions and their applications as a versatile platform for drug delivery, food applications, and pesticide formulations. Methods: Research relevant scientific literature across various databases, including PubMed, Scopus, and Web of Science. Suitable keywords for this purpose include "nanoemulsion," "drug delivery," and "food applications." Ensure the search criteria include recent publications to ensure current knowledge is included. Results: Several benefits have been demonstrated in the delivery of drugs using nanoemulsions, including improved solubility, increased bioavailability, and controlled delivery. Nanoemulsions have improved some bioactive compounds in food applications, including vitamins and antioxidants. At the same time, pesticide formulations based on nanoemulsions have also improved solubility, shelf life, and effectiveness. Conclusion: The versatility of nanoemulsions makes them ideal for drug delivery, food, and pesticide formulation applications. These products are highly soluble, bioavailable, and targeted, providing significant advantages. More research and development are required to implement nanoemulsion-based products on a commercial scale.
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    Thiazolidin-2,4-Dione Scaffold: An Insight Into Recent Advances As Antimicrobial, Antioxidant, and Hypoglycemic Agents
    (Scopus, 22-10-10) Kumar, Harsh; Aggarwal, Navidha; Marwaha, Minakshi Gupta; Deep, Aakash; Chopra, Hitesh; Matin, Mohammed M.; Roy, Arpita; Emran, Talha Bin; Mohanta, Yugal Kishore; Ahmed, Ramzan; Mohanta, Tapan Kumar; Saravanan, Muthupandian; Marwaha, Rakesh Kumar; Al-Harrasi, Ahmed
    Heterocyclic compounds containing nitrogen and sulfur, especially those in the thiazole family, have generated special interest in terms of their synthetic chemistry, which is attributable to their ubiquitous existence in pharmacologically dynamic natural products and also as overwhelm- ingly powerful agrochemicals and pharmaceuticals. The thiazolidin-2,4-dione (TZD) moiety plays a central role in the biological functioning of several essential molecules. The availability of substi- tutions at the third and fifth positions of the Thiazolidin-2,4-dione (TZD) scaffold makes it a highly utilized and versatile moiety that exhibits a wide range of biological activities. TZD analogues exhibit their hypoglycemic activity by improving insulin resistance through PPAR-γ receptor activation, their antimicrobial action by inhibiting cytoplasmic Mur ligases, and their antioxidant action by scavenging reactive oxygen species (ROS). In this manuscript, an effort has been made to review the research on TZD derivatives as potential antimicrobial, antioxidant, and antihyperglycemic agents from the period from 2010 to the present date, along with their molecular mechanisms and the information on patents granted to TZD analogues.