Browsing by Author "Krishnan, Karthickeyan"

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    Indole Alkaloids From Marine Resources: Understandings From Therapeutic Point of View To Treat Cancers
    (Chemico-Biological Interactions, 2023-08-28) Islam, Fahadul; Dehbia, Zerrouki; Zehravi, Mehrukh; Das, Rajib; Sivakumar, M.; Krishnan, Karthickeyan; Billah, Abdul Ajeed Mohathasim; Bose, Bharadhan; Ghosh, Avoy; Paul, Shyamjit; Nainu, Firzan; Ahmad, Irfan; Emran, Talha Bin
    Cancer is the leading cause of mortality all over the world. Scientific investigation has demonstrated that disruptions in the process of autophagy are frequently interrelated with the emergence of cancer. Hence, scientists are seeking permanent solutions to counter the deadly disease. Indole alkaloids have been extensively studied and are acknowledged to exhibit several bioactivities. The current state of disease necessitates novel pharmacophores development. In recent decades, indole alkaloids have become increasingly significant in cancer treatment and are also used as adjuvants. A substantial amount of pharmacologically active molecules come from indole alkaloids, which are widely distributed in nature. Indole alkaloids derived from marine organisms show immense potential for therapeutic applications and seem highly effective in cancer treatment. A couple of experiments have been conducted preclinically to investigate the possibility of indole alkaloids in cancer treatment. Marine-derived indole alkaloids possess the ability to exhibit anticancer properties through diverse antiproliferative mechanisms. Certain indole alkaloids, including vincristine and vinblastine, were verified in clinical trials or are presently undergoing clinical assessments for preventing and treating cancer. Indole alkaloids from marine resources hold a significant functionality in identifying new antitumor agents. The current literature highlights recent advancements in indole alkaloids that appear to be anticancer agents and the underlying mechanisms. © 2023 Elsevier B.V.
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    Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment
    (MDPI Publications, 2023-11-07) Al Amin, Md.; Emran, Talha Bin; Khan, Jishan; Zehravi, Mehrukh; Sharma, Indu; Patil, Anasuya; Gupta, Jeetendra Kumar; Jeslin, D.; Krishnan, Karthickeyan; Das, Rajib; Nainu, Firzan; Ahmad, Irfan; Wilairatana, Polrat
    Cancer is the leading cause of morbidity and mortality in people throughout the world. There are many signaling pathways associated with cancerous diseases, from which the Mitogen-activated protein kinase (MAPK) pathway performs a significant role in this regard. Apoptosis and proliferation are correlated with MAPK signaling pathways. Plenty of experimental investigations were carried out to assess the role of indole alkaloids in MAPK-mediated cancerous diseases. Previous reports established that indole alkaloids, such as vincristine and evodiamine are useful small molecules in cancer treatment via the MAPK signaling system. Indole alkaloids have the anticancer potential through different pathways. Vincristine and evodiamine are naturally occurring indole alkaloids that have strong anticancer properties. Additionally, much research is ongoing or completed with molecules belonging to this group. The current review aims to evaluate how indole alkaloids affect the MAPK signaling pathway in cancer treatment. Additionally, we focused on the advancement in the role of indole alkaloids, with the intention of modifying the MAPK signaling pathways to investigate potential new anticancer small molecules. Furthermore, clinical trials with indole alkaloids in cancer treatment are also highlighted.