Browsing by Author "Khan, Muhammad Saad"

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Computer-Aided Drug Design-Based System Pharmacology Applications for the Treatment of Diabetes Mellitus
(Elsevier, 2023-06-15) Bibi, Shabana; Hasan, Mohammad Mehedi; Hossain, Md. Shahadat; Khan, Muhammad Saad; Yousafi, Qudsia; Islam, Fahadul; Chopra, Hitesh; Kamal, Mohammad Amjad
Diabetes mellitus is a very complicated and long-term disease. Diabetic patients are always at risk of creating more complicated diseases in a very short time, as the damage of body organs is very fast if the situation becomes serious and untreated properly. Until yet there is no such medicine that could properly or completely treat diabetes mellitus. So there is an urgent need for advanced computational methods to identify novel therapeutics in a short time and at cheap rates. In this chapter, we have explained the status of diabetes mellitus, publications records, cases studies, mathematical models, and the importance of computer-aided aided design and its application in network pharmacology for the medicinal research of diabetes mellitus, also highlighted different medicine and potential targets for promoting antidiabetic drug research. More detailed studies of diabetic patients’ data set are required using advanced computational power to facilitate and speed up the antidiabetic drug research.
Green Metallic Nanoparticles
(Daffodil International University, 2022-04-06) Chopra, Hitesh; Bibi, Shabana; Singh, Inderbir; Hasan, Mohammad Mehedi; Khan, Muhammad Saad; Yousafi, Qudsia; Baig, Atif Amin; Rahman, Md. Mominur; Islam, Fahadul; Emran, Talha Bin; Cavalu, Simona
Current advancements in nanotechnology and nanoscience have resulted in new nanomaterials, which may pose health and environmental risks. Furthermore, several researchers are working to optimize ecologically friendly procedures for creating metal and metal oxide nanoparticles. The primary goal is to decrease the adverse effects of synthetic processes, their accompanying chemicals, and the resulting complexes. Utilizing various biomaterials for nanoparticle preparation is a beneficial approach in green nanotechnology. Furthermore, using the biological qualities of nature through a variety of activities is an excellent way to achieve this goal. Algae, plants, bacteria, and fungus have been employed to make energy-efficient, low-cost, and nontoxic metallic nanoparticles in the last few decades. Despite the environmental advantages of using green chemistry-based biological synthesis over traditional methods as discussed in this article, there are some unresolved issues such as particle size and shape consistency, reproducibility of the synthesis process, and understanding of the mechanisms involved in producing metallic nanoparticles via biological entities. Consequently, there is a need for further research to analyze and comprehend the real biological synthesis-dependent processes. This is currently an untapped hot research topic that required more investment to properly leverage the green manufacturing of metallic nanoparticles through living entities. The review covers such green methods of synthesizing nanoparticles and their utilization in the scientific world.
Natural Therapeutics and Nutraceuticals for Lung Diseases
(Daffodil International University, 2022-05-20) Rahman, Md. Mominur; Bibi, Shabana; Rahaman, Md. Saidur; Rahman, Firoza; Islam, Fahadul; Khan, Muhammad Saad; Hasan, Mohammad Mehedi; Parvez, Anwar; Hossain, Md. Abid; Maeesa, Saila Kabir; Islam, Md. Rezaul; Najda, Agnieszka; Al-malky, Hamdan S.; Mohamed, Hanan R.H.; AlGwaiz, Hussah I.M.; Awaji j, Aeshah A.; K., Mousa O. Germoush; Kensara, Osama A.; Abdel-Daim, Mohamed M.; Saeed, Mohd; Amjad, Mohammad
Background Lung diseases including chronic obstructive pulmonary disease (COPD), infections like influenza, acute respiratory distress syndrome (ARDS), asthma and pneumonia lung cancer (LC) are common causes of sickness and death worldwide due to their remoteness, cold and harsh climatic conditions, and inaccessible health care facilities. Purpose Many drugs have already been proposed for the treatment of lung diseases. Few of them are in clinical trials and have the potential to cure infectious diseases. Plant extracts or herbal products have been extensively used as Traditional Chinese Medicine (TCM) and Indian Ayurveda. Moreover, it has been involved in the inhibition of certain genes/protiens effects to promote regulation of signaling pathways. Natural remedies have been scientifically proven with remarkable bioactivities and are considered a cheap and safe source for lung disease. Methods This comprehensive review highlighted the literature about traditional plants and their metabolites with their applications for the treatment of lung diseases through experimental models in humans. Natural drugs information and mode of mechanism have been studied through the literature retrieved by Google Scholar, ScienceDirect, SciFinder, Scopus and Medline PubMed resources against lung diseases. Results In vitro, in vivo and computational studies have been explained for natural metabolites derived from plants (like flavonoids, alkaloids, and terpenoids) against different types of lung diseases. Probiotics have also been biologically active therapeutics against cancer, anti-inflammation, antiplatelet, antiviral, and antioxidants associated with lung diseases. Conclusion The results of the mentioned natural metabolites repurposed for different lung diseases especially for SARS-CoV-2 should be evaluated more by advance computational applications, experimental models in the biological system, also need to be validated by clinical trials so that we may be able to retrieve potential drugs for most challenging lung diseases especially SARS-CoV-2.
The potential of ketogenic dietary therapy in the COVID-19 pandemic
(Scopus, 2024) Hussain, Rashid; Bibi, Shabana; Akash, Shopnil; Yousafi, Qudsia; Khan, Muhammad Saad; Chopra, Hitesh
The coronavirus disease of 2019 (COVID-19) has been responsible for causing a lot of problems for the whole world for the past 3 years, and scientists are continuously doing research to find potential natural medicines and foods to control and prevent this acute disease. The risk factors that belong to this viral disease include obesity and metabolic diseases such as hypertension, diabetes, etc. A diet containing low carbohydrate concentrations and high fat concentrations is known as the ketogenic diet (KD). It helps to fight COVID-19. Acute COVID-19 infections are associated with the cytokine storm and acute respiratory distress syndrome. In chronic obstructive pulmonary disease patients, high-carbohydrate diets may lead to increased carbon dioxide generation and oxygen intake. Macrophages and monocytes are attracted to COVID-19 infection and deter them. This coronavirus type is adversely affected by obstructive sleep apnea syndrome. Hence, there is an urgent need to understand the importance of a KD, which could enhance the immune system and could be helpful in preventing metabolic and cardiovascular diseases and after-effects of the diseases in COVID-19 patients. Hence, sophisticated research is required in this specific domain to control the epidemic of COVID-19.