Browsing by Author "Jha, Niraj Kumar"

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    Current Trends of Computational Tools in Geriatric Medicine and Frailty Management
    (Daffodil International University, 2022-07-19) Louka, Anna Maria; Tsagkaris, Christos; Christoforou, Panagiotis; Khan, Andleeb; Alexiou, Filia; Simou, Panagiota; Haranas, Loannis; Gkigkitzis, Loannis; Zouganelis, Georgios; Jha, Niraj Kumar; Uddin, Md Sahab; Shen, Bairong; Kamal, Mohammad A.; Ashraf, Ghulam Md; Alexiou, Athanasios
    While frailty corresponds to a multisystem failure, geriatric assessment can recognize multiple pathophysiological lesions and age changes. Up to now, a few frailty indexes have been introduced, presenting definitions of psychological problems, dysregulations in nutritional intake, behavioral abnormalities, and daily functions, genetic, environmental, and cardiovascular comorbidities. The geriatric evaluation includes a vast range of health professionals; therefore, we describe a broad range of applications and frailty scales-biomarkers to investigate and formulate the relationship between frailty lesions, diagnosis, monitoring, and treatment. Additionally, artificial intelligence applications and computational tools are presented, targeting a more efficacy individualized geriatric management of healthy aging.
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    Nutraceuticals and Mitochondrial Oxidative Stress
    (Daffodil International University, 2022-07-07) Allam, Venkata Sita Rama Raju; Paudel, Keshav Raj; Gupta, Gaurav; Singh, Sachin Kumar; Vishwas, Sukriti; Gulati, Monica; Gupta, Saurabh; Chaitanya, M. V. N. L.; Jha, Niraj Kumar; Gupta, Piyush Kumar; Patel, Vyoma K.; Liu, Gang; Kamal, Mohammad Amjad; Hansbro, Philip M.; Oliver, Brian Gregory George; Chellappan, Dinesh Kumar; Dua, Kamal
    is a chronic inflammatory disease primarily characterized by inflammation and reversible bronchoconstriction. It is currently one of the leading causes of morbidity and mortality in the world. Oxidative stress further complicates the pathology of the disease. The current treatment strategies for asthma mainly involve the use of anti-inflammatory agents and bronchodilators. However, long-term usage of such medications is associated with severe adverse effects and complications. Hence, there is an urgent need to develop newer, novel, and safe treatment modalities for the management of asthma. This has therefore prompted further investigations and detailed research to identify and develop novel therapeutic interventions from potent untapped resources. This review focuses on the significance of oxidative stressors that are primarily derived from both mitochondrial and non-mitochondrial sources in initiating the clinical features of asthma. The review also discusses the biological scavenging system of the body and factors that may lead to its malfunction which could result in altered states. Furthermore, the review provides a detailed insight into the therapeutic role of nutraceuticals as an effective strategy to attenuate the deleterious effects of oxidative stress and may be used in the mitigation of the cardinal features of bronchial asthma.