Browsing by Author "Jahan, Sadia"

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A comprehensive review on the use of nanoparticles in alzheimer’s disease: a promising therapeutic approach
(BRAC University, 2024-12) Jahan, Sadia; Sharmin, Sabrina
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. Currently, there is no definitive cure for this condition. Traditional treatment approaches face challenges, such as limited drug bioavailability and the difficulty of drugs crossing the blood-brain barrier (BBB). However, nanoparticles (NPs) have emerged as a promising solution, offering a targeted and efficient drug delivery system. These nanoscale carriers can enhance the bioavailability of therapeutic agents and enable controlled release of active substances while bypassing the BBB. This paper reviews the therapeutic applications of nanoparticles in AD, emphasizing their potential to deliver antiinflammatory, antioxidant, and amyloid-targeting drugs directly to affected brain regions. It discusses various types of nanoparticle-based formulations, including liposomes, polymeric NPs, and metallic NPs, highlighting their multifunctional roles in diagnostic imaging and the early detection of AD biomarkers. Furthermore, the paper addresses concerns regarding potential cytotoxicity, long-term biocompatibility, and regulatory challenges. This comprehensive review underscores the transformative potential of nanoparticles in managing AD, paving the way for innovative and personalized medical interventions.
A Production Report On The Management Practice of Small Scale Dairy Farm
(Chattogram Veterinary and Animal Sciences University Chattogram-4225, Bangladesh, 2020-09) Jahan, Sadia
The report makes an attempt to know the management practices of small-scale dairy farms at Savar upazila, Dhaka. All activities of husbandry related to housing, breeding feeding, milking, cleaning, washing, waste and disease management of dairy farms were observed and farmers were interviewed using a questionnaire. Level of milk producers on various dairy management practices with the help of an empirical study conducted in Savar. Farmers of different dairy farms follow different rules and regulations in small scale dairy farming. The findings have clearly shown that milk producing cows are increasing day by day but quality of management practices was moderate. Constrains of dairy farm management are arising faced by dairy farmers. As a result problems should be overcome and knowledge level of farmers in dairy farm management should be enriched.
Pathological Investigation on different forms of E. coli infections (colibacillosis) in broiler chicken and molecular confirmation
(Chattogram Veterinary and Animal Sciences University, Khulshi-Chattogram-4225, 2023-06) Jahan, Sadia
Avian colibacillosis is a significant global infectious disease in birds of all ages, leading to substantial economic losses in poultry production. This disease is caused by Escherichia coli infection which is a highly prevalent bacterial pathogen in man and animals. Colibacillosis is a multifaceted syndrome distinguished by various organ abnormalities, including air sacculitis (61.67%), pericarditis (58.33%), perihepatitis (33.33%), yolk sac infection (35%), enteritis (31.67%). Research involving pathological examinations was conducted on spontaneous occurrences of avian colibacillosis to investigate the prevalence and pathological manifestations of Escherichia coli infection. After necropsy, we collected samples from lung, liver and spleen for bacterial isolation and subsequently for histopathological examinations. Following the bacterial isolation process, when we cultured the bacteria on agar, the outcomes revealed colonies with a distinct pink coloration on MacConkey agar and a distinctive metallic sheen on EMB agar. These characteristics led to the identification and consideration of E. coli in 45 cases. To confirm the presence of E. coli, PCR was conducted using the housekeeping gene primer (adk), resulting in the confirmation of E. coli in 37 suspected cases initially identified from agar cultures. Microscopic examinations revealed severe congestion (83.33%), hemorrhage (90%), focal area of necrosis (76.67%), prominent nuclear and cytoplasmic changes in hepatocytes with like fatty change (33.33%) in liver. In lung, edema (20%) and congestion (75%) were commonly observed almost all cases with thickening of alveolar septa. Hemorrhage and congestion (66.67%) also observed commonly in spleen along with depletion of lymphoid elements and multiple focal areas of necrosis (33.33%) in the primary follicles resulted in the formation of secondary germinal centers. Depletion of lymphocytes at times also accompanied by reticular cell proliferation (50%) in spleen. This study underscores the significant cellular-level changes associated with colibacillosis in commercially raised broiler chickens and suggests the need for further investigation to identify the specific serotypes of E. coli present in these chicken populations.