Browsing by Author "Islam, Mohammad A."

Now showing 1 - 8 of 8

Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions
(© 2012 Ars Pharmaceutica, 2012) Shihab-us-Sakib, Khondoker; Islam, Mohammad A.; Moniruzzaman, M.; Hussein, Anwar; Hossain, M. Mahboob; Mazid, Mohammad A.
Aims: The binding of atenolol a selective β1 receptor antagonist and desloratadine, an H1 receptor antagonist, to bovine serum albumin. Methods: The analysis of binding was studied by equilibrium dialysis method (ED) using ranitidine and diazepam as site-1 and site-2 specific probe, respectively. Results: The study suggested two sets of association constants, for atenolol: high affinity association constant (k1 = 5 × 10-5 M-1) with low capacity (n1 = 2) and low affinity association constant (k2 = 2.5 × 10-5 M-1) with high capacity (n2 = 5), while for desloratadine: high affinity association constant (k1 = 45 × 10-5 M-1) with low capacity (n1 = 1.3) and low affinity association constant (k 2 = 5 × 10-5 M-1) with high capacity (n2 = 2.5) at pH 7.4 and 27 °C. During concurrent administration of atenolol and desloratadine in presence or absence of ranitidine or diazepam, desloratadine causes the release of atenolol from its binding site on BSA resulting reduced binding of atenolol to BSA. The increment in free fraction of atenolol was from 84.01% to 99 % upon the addition of increased concentration of only desloratadine at a concentration of 0 × 10-5 M to 14 × 10 -5 M. In presence of diazepam as site-II specific probes, desloratadine further increases the free fraction of atenolol was from 0.45% to 14.3%. Conclusion: These data were indicative for the interaction of higher concentration of desloratadine at the binding sites on BSA changing the pharmacokinetics properties of atenolol.
Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions
(© 2012 Ars Pharmaceutica, 2012) Shihab-us-Sakib, Khondoker; Islam, Mohammad A.; Moniruzzaman, M.; Hussein, Anwar; Hossain, M. Mahboob; Mazid, Mohammad A.
Aims: The binding of atenolol a selective β1 receptor antagonist and desloratadine, an H1 receptor antagonist, to bovine serum albumin. Methods: The analysis of binding was studied by equilibrium dialysis method (ED) using ranitidine and diazepam as site-1 and site-2 specific probe, respectively. Results: The study suggested two sets of association constants, for atenolol: high affinity association constant (k1 = 5 × 10-5 M-1) with low capacity (n1 = 2) and low affinity association constant (k2 = 2.5 × 10-5 M-1) with high capacity (n2 = 5), while for desloratadine: high affinity association constant (k1 = 45 × 10-5 M-1) with low capacity (n1 = 1.3) and low affinity association constant (k 2 = 5 × 10-5 M-1) with high capacity (n2 = 2.5) at pH 7.4 and 27 °C. During concurrent administration of atenolol and desloratadine in presence or absence of ranitidine or diazepam, desloratadine causes the release of atenolol from its binding site on BSA resulting reduced binding of atenolol to BSA. The increment in free fraction of atenolol was from 84.01% to 99 % upon the addition of increased concentration of only desloratadine at a concentration of 0 × 10-5 M to 14 × 10 -5 M. In presence of diazepam as site-II specific probes, desloratadine further increases the free fraction of atenolol was from 0.45% to 14.3%. Conclusion: These data were indicative for the interaction of higher concentration of desloratadine at the binding sites on BSA changing the pharmacokinetics properties of atenolol.
Effect of early vitamin A supplementation on cell-mediated immunity in infants younger than 6 mo
(1997-01) Rahman, Mohammad M.; Mahalanabis, Dilip; Alvarez, Jose O.; Wahed, Mohammad A.; Islam, Mohammad A.; Habte, Demissie
Effect of vitamin A administration on response to oral polio vaccination
(1998) Rahman, Mohammad M.; Alvarez, Jose O.; Mahalanabis, Dilip; Wahed, Mohammad A.; Islam, Mohammad A.; Unicomb, Leanne; Habte, Demissie; Fuchs, George J.
Informal allopathic provider knowledge and practice regarding control and prevention of TB in rural Bangladesh
(International Health, 6/17/2014) Islam, Qazi S.; Ahmed, Syed M.; Islam, Mohammad A.; Chowdhury, Anita S.; Siddiquea, Bodrun N.; Husain, Mohammad A.
Background: BRAC (formerly Bangladesh Rural Advancement Committee), in collaboration with the National Tuberculosis Control Programme, provides one full-day training on TB to make informal allopathic providers knowledgeable for managing TB in rural Bangladesh. This study explored the knowledge and practices of the providers receiving the above training in the control and prevention of TB. Methods: The study was conducted in 30 subdistricts, with 30 trained and 30 untrained providers randomly selected from each subdistrict. Approximately 3% (49/1800) did not provide complete information. Pre-tested structured and semi-structured questionnaires were used. Results: TB was commonly perceived as a disease of only males (66.1%, 1157/1751). Only one-quarter knew about the bacterial cause of TB. Very few providers (2.1%, 36) had adequate knowledge regarding prevention of TB. They also lacked knowledge about TB treatment duration (71.6%, 1253), the meaning of DOTS (directly observed treatment, short course) (26.0%, 455) and multidrug resistance (20.6%, 360). Antibiotics (79.7%, 1396) and cough syrup (75.0%, 1313) were commonly prescribed by providers despite symptoms suggestive of TB. However, 70.2% (613) and 74.5% (650) of trained providers’ knowledge and practice scores were equal to or more than the mean scores (≥6.97 and ≥6.6, respectively), whereas they were only 49.5% (435) and 64.2% (563), respectively, among untrained providers (p,0.0001). Conclusions: Misperception, lack of knowledge and irrational use of antibiotics are challenges that need to be addressed for controlling and preventing TB efficiently.
Informal allopathic provider knowledge and practice regarding control and prevention of TB in rural Bangladesh
(International Health, 6/17/2014) Islam, Qazi S.; Ahmed, Syed M.; Islam, Mohammad A.; Chowdhury, Anita S.; Siddiquea, Bodrun N.; Husain, Mohammad A.
Background: BRAC (formerly Bangladesh Rural Advancement Committee), in collaboration with the National Tuberculosis Control Programme, provides one full-day training on TB to make informal allopathic providers knowledgeable for managing TB in rural Bangladesh. This study explored the knowledge and practices of the providers receiving the above training in the control and prevention of TB. Methods: The study was conducted in 30 subdistricts, with 30 trained and 30 untrained providers randomly selected from each subdistrict. Approximately 3% (49/1800) did not provide complete information. Pre-tested structured and semi-structured questionnaires were used. Results: TB was commonly perceived as a disease of only males (66.1%, 1157/1751). Only one-quarter knew about the bacterial cause of TB. Very few providers (2.1%, 36) had adequate knowledge regarding prevention of TB. They also lacked knowledge about TB treatment duration (71.6%, 1253), the meaning of DOTS (directly observed treatment, short course) (26.0%, 455) and multidrug resistance (20.6%, 360). Antibiotics (79.7%, 1396) and cough syrup (75.0%, 1313) were commonly prescribed by providers despite symptoms suggestive of TB. However, 70.2% (613) and 74.5% (650) of trained providers’ knowledge and practice scores were equal to or more than the mean scores (≥6.97 and ≥6.6, respectively), whereas they were only 49.5% (435) and 64.2% (563), respectively, among untrained providers (p,0.0001). Conclusions: Misperception, lack of knowledge and irrational use of antibiotics are challenges that need to be addressed for controlling and preventing TB efficiently.
Informal allopathic provider knowledge and practice regarding control and prevention of TB in rural Bangladesh
(International Health, 6/17/2014) Islam, Qazi S.; Ahmed, Syed M.; Islam, Mohammad A.; Chowdhury, Anita S.; Siddiquea, Bodrun N.; Husain, Mohammad A.
Background: BRAC (formerly Bangladesh Rural Advancement Committee), in collaboration with the National Tuberculosis Control Programme, provides one full-day training on TB to make informal allopathic providers knowledgeable for managing TB in rural Bangladesh. This study explored the knowledge and practices of the providers receiving the above training in the control and prevention of TB. Methods: The study was conducted in 30 subdistricts, with 30 trained and 30 untrained providers randomly selected from each subdistrict. Approximately 3% (49/1800) did not provide complete information. Pre-tested structured and semi-structured questionnaires were used. Results: TB was commonly perceived as a disease of only males (66.1%, 1157/1751). Only one-quarter knew about the bacterial cause of TB. Very few providers (2.1%, 36) had adequate knowledge regarding prevention of TB. They also lacked knowledge about TB treatment duration (71.6%, 1253), the meaning of DOTS (directly observed treatment, short course) (26.0%, 455) and multidrug resistance (20.6%, 360). Antibiotics (79.7%, 1396) and cough syrup (75.0%, 1313) were commonly prescribed by providers despite symptoms suggestive of TB. However, 70.2% (613) and 74.5% (650) of trained providers’ knowledge and practice scores were equal to or more than the mean scores (≥6.97 and ≥6.6, respectively), whereas they were only 49.5% (435) and 64.2% (563), respectively, among untrained providers (p,0.0001). Conclusions: Misperception, lack of knowledge and irrational use of antibiotics are challenges that need to be addressed for controlling and preventing TB efficiently.
Vitamin A megadoses during early infancy on serum rentinol concentration and acute side effects and residual effects on 6 month follow up
(1997-04) Mahalanabis, Dilip; Rahman, Mohammad A.; Wahed, Mohammad A.; Islam, Mohammad A.; Habte, Demissie