Browsing by Author "Imran, Muhammad"

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Association of Type 2 Diabetes and Hepatitis C Virus Infection in Pakistani Population
(Daffodil International University, 22-07-14) Safi, Sher Zaman; Shah, Humaira; Imran, Muhammad; Noreen, Mamoon; Latif, Zahira; Rehman, Fouzia; Ali, Abid; Muhammad, Naushad; Waheed, Yasir; Emran, Talha Bin; Khan, Shah Alam; Subramaniyan, Vorticella; Ismail, Ikram Shah Bin
In Pakistan and other developing countries, the available data on the association of T2DM and HCV is limited. We therefore made an attempt to report the association of HCV and diabetes in Pakistani population through this meta-analysis. HCV and diabetes related studies were identified using various key words, from a number of databases including CINAHL, PubMed, Web of Science and Embase. Using RevMan5, the main outcome was regarded as type 2 diabetes associations with hepatitis c virus infection in Pakistan. Independent analyses were made for “HCV in diabetic patients” and “diabetes cases in hepatitis C virus patients”. Using random effect model, odds ratios were calculated with 95% CIs (dichotomous data). I2 statistics were used to calculate heterogeneity. From a total of 53 studies, we finally selected 6 studies for the meta-analysis. Using random effects model, hepatitis c virus patients in 3 studies (n = 1,902) demonstrated that HCV is a risk factor in developing diabetes, contrary to patients with no HCV infection (OR 0.01, 95% CI: 0.00-0.06, I2 = 0%; RR 0.01, 95% CI: 0.00-0.07, I2 = 0%). The remaining 3 studies (n = 13,710) had reported HCV infections in type 2 diabetic patients and patients with no diabetes. Similarly, our meta-analysis revealed higher prevalence of HCV infections in patients with type 2 diabetes (OR 0.7, 95% CI: 0.17-0.42, I2 = 32%; RR 0.30, 95% CI: 0.20-0.46, I2 = 32%) as compared to patients with no type 2 diabetes mellitus. Our meta-analysis demonstrates a significant link between HCV and T2DM. Further studies are recommended with adequate sample sizes. © 2022, Prince of Songkla University. All rights reserved.
Berberine as a Potential Anticancer Agent
(Molecules, 2021) Rauf, Abdur; Abu-Izneid, Tareq; Khalil, Anees Ahmed; Imran, Muhammad; Ali Shah, Zafar; Emran, Talha Bin; Mitra, Saikat; Khan, Zidan; Alhumaydhi, Fahad A; S M Aljohani, Abdullah; Khan, Ishaq; Rahman, Md Mominur; Jeandet, Philippe; Gondal, Tanweer Aslam
Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial amount of research has been conducted to date to establish the anticancer potential of BBR. The present review consolidates salient information concerning the promising anticancer activity of this compound. The therapeutic efficacy of BBR has been reported in several studies regarding colon, breast, pancreatic, liver, oral, bone, cutaneous, prostate, intestine, and thyroid cancers. BBR prevents cancer cell proliferation by inducing apoptosis and controlling the cell cycle as well as autophagy. BBR also hinders tumor cell invasion and metastasis by down-regulating metastasis-related proteins. Moreover, BBR is also beneficial in the early stages of cancer development by lowering epithelial-mesenchymal transition protein expression. Despite its significance as a potentially promising drug candidate, there are currently no pure berberine preparations approved to treat specific ailments. Hence, this review highlights our current comprehensive knowledge of sources, extraction methods, pharmacokinetic, and pharmacodynamic profiles of berberine, as well as the proposed mechanisms of action associated with its anticancer potential. The information presented here will help provide a baseline for researchers, scientists, and drug developers regarding the use of berberine as a promising candidate in treating different types of cancers.
Efficient Arsenate Decontamination From Water Using MgO-Itsit Biochar Composite
(Scopus, 22-11-05) Uddin, Salah; Hussain, Babar; Haq, Sirajul; Imran, Muhammad; Ahmad, Pervaiz; Khandaker, Mayeen Uddin; Rehman, Fazal Ur; Eldin, Sayed M.; Mousa, Abd Allah A.; Khan, Ilyas; Emran, Talha Bin
(1) Background: In this investigation, a composite of MgO nanoparticles with Itsit biochar (MgO-IBC) has been used to remove arsenate from contaminated water. The reduced adsorption capacity of biochar (IBC), due to loss of functionalities under pyrolysis, is compensated for with the composite MgO-IBC. (2) Methods: Batch scale adsorption experiments were conducted by using MgO-IBC as an adsorbent for the decontamination of arsenate from water. Functional groups, elemental composition, surface morphology, and crystallinity of the adsorbent were investigated by using FTIR, EDX, SEM and XRD techniques. The effect of pH on arsenate adsorption by MgO-IBC was evaluated in the pH range of 2 to 8, whereas the temperature effect was investigated in the range of 303 K to 323 K. (3) Results: Both pH and temperature were found to significantly influence the overall adsorption efficiency of MgO-IBC for arsenate adsorption with lower pH and higher temperature being suitable for higher arsenate adsorption. A kinetics study of arsenate adsorption confirmed an equilibrium time of 240 min and a pseudo-second-order model well-explained the kinetic adsorption data, whereas the Langmuir model best fitted with the equilibrium arsenate adsorption data. The spontaneity and the chemisorptive nature of arsenate adsorption was confirmed by enthalpy, entropy, and activation energy. Comparison of adsorbents in the literature with the current study indicates that MgO-IBC composite has better adsorption capacity for arsenate adsorption than several previously explored adsorbents. (4) Conclusions: The higher adsorption capacity of MgO-IBC confirms its suitability and efficient utilization for the removal of arsenate from water.
Heparin-Loaded Alginate Hydrogels
(Scopus, 22-10-28) Nawaz, Ayesha; Safi, Sher Zaman; Sikandar, Shomaila; Zeeshan, Rabia; Zulfiqar, Saima; Mehmood, Nadia; M Alobaid, Hussah; Rehman, Fozia; Imran, Muhammad; Tariq, Muhammad; Ali, Abid; Emran, Talha Bin; Yar, Muhammad
Background: Chronic wounds continue to be a global concern that demands substantial resources from the healthcare system. The process of cutaneous wound healing is complex, involving inflammation, blood clotting, angiogenesis, migration and remodeling. In the present study, commercially available alginate wound dressings were loaded with heparin. The purpose of the study was to enhance the angiogenic potential of alginate wound dressings and analyze the antibacterial activity, biocompatibility and other relevant properties. We also aimed to conduct some molecular and gene expression studies to elaborate on the mechanisms through which heparin induces angiogenesis. Methods: The physical properties of the hydrogels were evaluated by Fourier transform infrared spectroscopy (FTIR). Swelling ability was measured by soaking hydrogels in the Phosphate buffer at 37 °C, and cell studies were conducted to evaluate the cytotoxicity and biocompatibility of hydrogels in NIH3T3 (fibroblasts). Real-time PCR was conducted to check the molecular mechanisms of heparin/alginate-induced angiogenesis. The physical properties of the hydrogels were evaluated by Fourier transform infrared spectroscopy (FTIR). Results: FTIR confirmed the formation of heparin-loaded alginate wound dressing and the compatibility of both heparin and alginate. Among all, 10 µg/mL concentration of heparin showed the best antibacterial activity against E. coli. The swelling was considerably increased up to 1500% within 1 h. Alamar Blue assay revealed no cytotoxic effect on NIH3T3. Heparin showed good anti-microbial properties and inhibited the growth of E. coli in zones with a diameter of 18 mm. The expression analysis suggested that heparin probably exerts its pro-angiogenetic effect through VEGF and cPGE. Conclusions: We report that heparin-loaded alginate dressings are not cytotoxic and offer increased angiogenic and anti-bacterial potential. The angiogenesis is apparently taken through the VEGF pathway.
Mechanisms of β-Adrenergic Receptors Agonists in Mediating Pro and Anti-Apoptotic Pathways in Hyperglycemic Müller Cells
(Daffodil International University, 22-08-04) Saf, Sher Zaman; Saeed, Laiba; Shah, Humaira; Latif, Zahina; Ali, Abid; Imran, Muhammad; Muhammad, Nawshad; Emran, Talha Bin; Subramaniyan, Vetriselvan; Ismail, Ikram Shah Bin
Background: The current study aimed to investigate the stimulatory effect of beta-adrenergic receptors (β-ARs) on brain derived neurotropic factor (BDNF) and cAMP response element binding protein (CREB). Methods: Human Müller cells were cultured in low and high glucose conditions. Cells were treated with xamoterol (selective agonist for β1-AR), salmeterol (selective agonist for β2-AR), isoproterenol (β-ARs agonist) and propranolol (β-ARs antagonist), at 20 µM concentration for 24 h. Western Blotting assay was performed for the gene expression analysis. DNA damage was evaluated by TUNEL assay. DCFH-DA assay was used to check the level of reactive oxygen species (ROS). Cytochrome C release was measured by ELISA. Results: Xamoterol, salmeterol and isoproterenol showed no effect on Caspase-8 but it reduced the apoptosis and increased the expression of BDNF in Müller cells. A significant change in the expression of caspase-3 was observed in cells treated with xamoterol and salmeterol as compared to isoproterenol. Xamoterol, salmeterol and isoproterenol significantly decreased the reactive oxygen species (ROS) when treated for 24 hours. Glucose-induced cytochrome c release was disrupted in Müller cells. Conclusion: β-ARs, stimulated by agonist play a protective role in hyperglycemic Müller cells, with the suppression of glucose-induced caspase-3 and cytochrome c release. B-Ars may directly mediate the gene expression of BDNF.
MEDIC: A Multi-Task Learning Dataset for Disaster Image Classification
(Springer Nature, 2022-09-03) Alam, Firoj; Alam, Tanvirul; Hasan, Md. Arid; Hasnat, Abul; Imran, Muhammad; Ofli, Ferda
Recent research in disaster informatics demonstrates a practical and important use case of artificial intelligence to save human lives and suffering during natural disasters based on social media contents (text and images). While notable progress has been made using texts, research on exploiting the images remains relatively under-explored. To advance image-based approaches, we propose MEDIC (https://crisisnlp.qcri.org/medic/index.html), which is the largest social media image classification dataset for humanitarian response consisting of 71,198 images to address four different tasks in a multi-task learning setup. This is the first dataset of its kind: social media images, disaster response, and multi-task learning research. An important property of this dataset is its high potential to facilitate research on multi-task learning, which recently receives much interest from the machine learning community and has shown remarkable results in terms of memory, inference speed, performance, and generalization capability. Therefore, the proposed dataset is an important resource for advancing image-based disaster management and multi-task machine learning research. We experiment with different deep learning architectures and report promising results, which are above the majority baselines for all tasks. Along with the dataset, we also release all relevant scripts
Photochemistry, Functional Properties, Food Applications, and Health Prospective of Black Rice
(Daffodil International University, 2022-10-14) Rahim, Muhammad Abdul; Umar, Maryam; Habib, Ayesha; Imran, Muhammad; Khalid, Waseem; Lima, Clara Mariana Gonçalves; Shoukat, Aurbab; Itrat, Nizwa; Nazir, Anum; Ejaz, Afaf; Zafar, Amna; Awuchi, Chinaza Godswill; Sharma, Rohit; Santana, Renata Ferreira; Emran, Talha Bin
This review investigates black rice’s photochemistry, functional properties, food applications, and health prospects. There are different varieties of black rice available in the world. The origins of this product can be traced back to Asian countries. This rice is also known as prohibited rice, emperor’s rice, and royal’s rice. Black rice is composed of different nutrients including fiber, protein, carbohydrates, potassium, and vitamin B complex. It contains an antioxidant called anthocyanin and tocopherols. Antioxidants are found mostly in foods that are black or dark purple. Due to its nutritious density, high fiber level, and high antioxidant content, black rice is a good alternative to white and brown rice. Utilizing black rice in various foods can enhance the nutritional value of food and be transformed into functional food items. Many noncommunicable diseases (NCDs) can be prevented by eating black rice daily, including cancer cells, atherosclerosis, hypertension, diabetes, osteoporosis, asthma, digestive health, and stroke risk. This review aim was to discuss the role of nutritional and functional properties of black rice in the formation of functional food against different noncommunicable diseases.
Qualitative and Quantitative Investigation of Biochar-Cu0 Composite for Nickel Adsorption
(ACS Publications, 2023-10-11) Uddin, Salah; Awan, Junaid Murtaza; Imran, Muhammad; Ahmad, Pervaiz; Haq, Sirajul; Shakil, Sana; Al-mugren, Kholoud; Alotibi, Satam; Alharthi, Abdulrahman I.; Khan, Muhammad Sarfraz; Khandaker, Mayeen Uddin
The current investigation deals with the treatment of water pollution that is caused by the leaching of nickel ions from the metallurgical industry and new-energy batteries. Therefore, an eco-friendly treatment of nickel through the use of a composite of cotton stalk biochar with nanozerovalent copper has been presented in this investigation signifying the impact of zerovalent copper in enhancing the adsorption capacity of biochar for nickel adsorption. Thermogravimetric analysis data showed the adsorbent to be significantly stable in the higher thermal range, whereas transmission electron microscopy analysis confirmed the particles to be 27 nm and also showed the cubic geometry of the particles. A much closer scanning electron microscopy analysis shows the morphology of particles to be cubic in shape. Batch adsorption indicated a positive influence of pH increase on adsorption due to the electrostatic attraction between positive nickel ions and post point of zero charge (pHPZC) negative surface of copper biochar composite (pH > 5.5). A high adsorption rate was observed in the first 60 min, whereas adsorption increased with the increase in temperature from 303 to 318 K. Kinetic modeling confirmed the pseudo-first-order to fit best to the data. The apparent activation energy (11.96 kJ mol–1) is indicative of the chemical nature of the process. The adsorption data fitted well to the Langmuir adsorption model. The negative values of apparent ΔG° and the positive values of apparent ΔH° indicate the spontaneity and endothermicity of the process, respectively, whereas the positive values of apparent ΔS° point toward increased randomness during the process. Postadsorption XPS suggests the adsorption of nickel on the surface of biochar composites in the form of Ni(OH)2 and NiO(OH).
Targeted Therapeutic Management Based on Phytoconstituents for Sickle Cell Anemia Focusing on Molecular Mechanisms: Current Trends and Future Perspectives
(Elsevier, 2024-08-04) Islam, Md. Rezaul; Rauf, Abdur; Akash, Shopnil; Sharker, Muntasir; Mahreen, Mashiat; Munira, Most Ayesha Khatun; Dhar, Puja Sutro; Hemeg, Hassan A.; Iriti, Marcello; Imran, Muhammad
The global epidemic of Sickle cell anemia (SCA) is causing thousands of children to die. SCA, a genetic disorder affecting the hemoglobin-globin chain, affects millions globally. The primary physiological issue in these patients is the polymerization of sickle hemoglobin within their red blood cells (RBCs) during their deoxygenating state. The RBC undergoes a sickle shape due to the polymerization of mutant hemoglobin within it and membrane deformation during anoxic conditions. To prevent complications, it is essential to effectively stop the sickling of RBCs of the patients. Various medications have been studied for treating SCA patients, focusing on antisickling, γ-globulin induction, and antiplatelet action. Natural and synthetic anti-sickling agents can potentially reduce patient clinical morbidity. Numerous clinical trials focused on using natural remedies for the symptomatic therapy of SCA. Medicinal plants and phytochemical agents have antisickling properties. Recent studies on plant extracts' natural compounds have primarily focused on in vitro RBCs sickling studies, with limited data on in vivo studies. This review discussed the potential role of phytoconstituents in the management of SCA.
Targeted therapeutic management based on phytoconstituents for sickle cell anemia focusing on molecular mechanisms: Current trends and future perspectives
(Scopus, 2024-10) Islam, Md. Rezaul; Rauf, Abdur; Akash, Shopnil; Sharker, Muntasir; Mahreen, Mashiat; Munira, Most Ayesha Khatun; Dhar, Puja Sutro; Hemeg, Hassan A.; Iriti, Marcello; Imran, Muhammad
The global epidemic of Sickle cell anemia (SCA) is causing thousands of children to die. SCA, a genetic disorder affecting the hemoglobin-globin chain, affects millions globally. The primary physiological issue in these patients is the polymerization of sickle hemoglobin within their red blood cells (RBCs) during their deoxygenating state. The RBC undergoes a sickle shape due to the polymerization of mutant hemoglobin within it and membrane deformation during anoxic conditions. To prevent complications, it is essential to effectively stop the sickling of RBCs of the patients. Various medications have been studied for treating SCA patients, focusing on antisickling, γ-globulin induction, and antiplatelet action. Natural and synthetic anti-sickling agents can potentially reduce patient clinical morbidity. Numerous clinical trials focused on using natural remedies for the symptomatic therapy of SCA. Medicinal plants and phytochemical agents have antisickling properties. Recent studies on plant extracts' natural compounds have primarily focused on in vitro RBCs sickling studies, with limited data on in vivo studies. This review discussed the potential role of phytoconstituents in the management of SCA.
Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin
(Daffodil International University, 2023) Rauf, Abdur; Izneid, Tareq Abu-; Imran, Muhammad; Hemeg, Hassan A; Bashir, Kashif; Aljohani, Abdullah S M; Aljohani, Mona S M; Alhumaydhi, Fahad A; Khan, Ishaq N; Emran, Talha Bin; Gondal, Tanweer Aslam; Nath, Nikhil; Ahmad, Ishtiaque; Thiruvengadam, Muthu
Flavonoids effectively treat cancer, inflammatory disorders (cardiovascular and nervous systems), and oxidative stress. Fisetin, derived from fruits and vegetables, suppresses cancer growth by altering cell cycle parameters that lead to cell death and angiogenesis without affecting healthy cells. Clinical trials are needed in humans to prove the effectiveness of this treatment for a wide range of cancers. According to the results of this study, fisetin can be used to prevent and treat a variety of cancers. Despite early detection and treatment advances, cancer is the leading cause of death worldwide. We must take proactive steps to reduce the risk of cancer. The natural flavonoid fisetin has pharmacological properties that suppress cancer growth. This review focuses on the potential drug use of fisetin, which has been extensively explored for its cancer-fighting ability and other pharmacological activities such as diabetes, COVID-19, obesity, allergy, neurological, and bone disorders. Researchers have focused on the molecular function of fisetin. In this review, we have highlighted the biological activities against chronic disorders, including cancer, metabolic illnesses, and degenerative illnesses, of the dietary components of fisetin.