Browsing by Author "Humayra, Syeda"

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Determinants and Predictors of Mental Health During and After COVID-19 Lockdown Among University Students in Malaysia
(PLOS ONE, 2023-01-20) Mir, Imtiyaz Ali; Ng, Shang Kuan; Jamali, Muhammad Noh Zulfikri Mohd; Jabbar, Mohammed AbdulRazzaq; Humayra, Syeda
"Background: Young adults, particularly university students might be at greater risk of developing psychological distress, and exhibiting symptoms of anxiety and depression during the COVID-19 pandemic. The primary objective of this study was to explore and compare the determinants and predictors of mental health (anxiety and depression) during and after the COVID-19 lockdown among university students. Methods: This was an observational, cross-sectional study with a sample size of 417 students. An online survey utilizing International Physical Activity Questionnaire-Short Form (IPAQ-SF), General Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) was distributed to Universiti Tunku Abdul Rahman students via Google forms. Results: During lockdown, family income [χ2 (1, n = 124) = 5.155, p = 0.023], and physical activity (PA) [χ2 (1, n = 134) = 6.366, p = 0.012] were associated with anxiety, while depression was associated with gender [χ2 (1, n = 75) = 4.655, p = 0.031]. After lockdown, family income was associated with both anxiety [χ2 (1, n = 111) = 8.089, p = 0.004], and depression [χ2 (1, n = 115) = 9.305, p = 0.002]. During lockdown, family income (OR = 1.60, p = 0.018), and PA (OR = 0.59, p = 0.011) were predictors for anxiety, while gender (OR = 0.65, p = 0.046) was a predictor for depression. After lockdown, family income was a predictor for both anxiety (OR = 1.67, p = 0.011), and depression (OR = 1.70, p = 0.009). Conclusion: Significant negative effects attributed to the COVID-19 lockdown, and certain factors predisposed to the worsening of mental health status in university students. Low family income, PA, and female gender were the major determinants and predictors linked to anxiety and depression."
Effectiveness of High-Intensity Interval Training and Continuous Moderate-Intensity Training on Blood Pressure in Physically Inactive Pre-Hypertensive Young Adults
(Daffodil International University, 2022-08-03) John, Anil T; Chowdhury, Moniruddin; Islam, Md Rabiul; Mir, Imtiyaz Ali; Hasan, Md Zobaer; Chong, Chao Yi; Humayra, Syeda; Higashi, Yukihito
The likelihood of pre-hypertensive young adults developing hypertension has been steadily increasing in recent years. Despite the fact that aerobic exercise training (AET) has demonstrated positive results in lowering high blood pressure, the efficacy of different types of AET among pre-hypertensive young adults has not been well-established. The objective of this study was to evaluate the effectiveness of high-intensity interval training (HIIT) and continuous moderate-intensity training (CMT) on the blood pressure (BP) of physically inactive pre-hypertensive young adults. In total, 32 adults (age 20.0 ± 1.1 years and BMI 21.5 ± 1.8) were randomly assigned to three groups: HIIT, CMT and control (CON). The HIIT and CMT groups participated in 5 weeks of AET, while the CON group followed a DASH diet plan only. The HIIT protocol consisted of a 1:4 min work to rest ratio of participants, at an 80-85% heart rate reserve (HR-reserve) and a 40-60% HR-reserve, respectively, for 20 min; the CMT group exercised at 40-60% of their HR-reserve continuously for 20 min. In both the HIIT and CMT groups, systolic blood pressure (SBP) (3.8 ± 2.8 mmHg, p = 0.002 vs. 1.6 ± 1.5 mmHg, p = 0.011) was significantly reduced, while significant reductions in the diastolic blood pressure (DBP) (2.9 ± 2.2 mmHg, p = 0.002) and mean arterial pressure (MAP) (3.1 ± 1.6 mmHg, p < 0.0005) were noted only in the HIIT group. No significant differences in SBP (-0.4 ± 3.7 mmHg, p = 0.718), DBP (0.4 ± 3.4 mmHg, p = 0.714), or MAP (0.1 ± 2.5 mmHg, p = 0.892) were observed in the CON group. Both HIIT and CMT decreased BP in physically inactive pre-hypertensive young adults; however, HIIT yielded more beneficial results in terms of reducing the SPB, DBP and MAP.
Use of Neutralizing Monoclonal Antibodies and Its Outcome Measures in COVID-19 Patients
(Daffodil International University, 2023-07-23) Chowdhury, Moniruddin; Humayra, Syeda
"Neutralizing monoclonal antibodies (mAbs) can stimulate protective immunity. Hence their rapid identification and characterization are incorporated into clinical practice to provide effective treatment and prophylaxis during the COVID-19 pandemic. Previously, mAbs have been effectively used in several other viral infections, including Ebola, influenza, HIV, RSV, Zika virus, and MERS-CoV. Currently, the utilization of mAbs appears to have favorable clinical outcomes in patients with mildmoderate SARS-CoV-2 infection, particularly individuals at high risk of hospitalization and progression to severe COVID-19. However, most of the interim results on antiSARS-CoV-2 mAbs are based on ongoing clinical trial data; thereby, several questions revolve around this novel therapy, including its long-term implication, application, and feasibility. Although, the use of neutralizing mAbs may assist in alleviating the critical burden on healthcare settings and minimizing hospital stay due to severe progression of the COVID-19 symptoms especially among those with poor immune responses to vaccination, elderly, and/or vaccine-refractory individuals. Nonetheless, there is a broader need to explore these - novel therapies for their effective use in clinical practice and to improve patient-related outcomes.