Browsing by Author "Haque, Shafiul"

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Multidrug Resistance in Cancer
(Daffodil International University, 2022-06-23) Emran, Talha Bin; Shahriar, Asif; Mahmud, Aar Rafi; Rahman, Tanjilur; Abir, Mehedy Hasan; Siddiquee, Mohd. Faijanur - Rob; Ahmed, Hossain; Rahman, Nova; Nainu, Firzan; Wahyudin, Elly; Mitra, Saikat; Dhama, Kuldeep; Habiballah, Mahmoud M.; Haque, Shafiul; Islam, Ariful; Hassan, Mohammad Mahmudul
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer.
Natural products in the management of neurodegenerative diseases
(2024-05-16) Rajat, Goyal; Mittal, Pooja; Gautam, Rupesh K.; Kamal, Mohammad Amjad; Perveen, Asma; Garg, Vandana; Alexiou, Athanasios; Saboor, Muhammad; Haque, Shafiul; Farhana, Aisha; Papadakis, Marios; Ashraf, Ghulam Md
Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of mortality. Natural derivatives are more efficacious in various preclinical models of neurodegenerative illnesses. These natural compounds include phytoconstituents in herbs, vegetables, fruits, nuts, and marine and freshwater flora, with remarkable efficacy in mitigating neurodegeneration and enhancing cognitive abilities in preclinical models. According to the latest research, the therapeutic activity of natural substances can be increased by adding phytoconstituents in nanocarriers such as nanoparticles, nanogels, and nanostructured lipid carriers. They can enhance the stability and specificity of the bioactive compounds to a more considerable extent. Nanotechnology can also provide targeting, enhancing their specificity to the respective site of action. In light of these findings, this article discusses the biological and therapeutic potential of natural products and their bioactive derivatives to exert neuroprotective effects and some clinical studies assessing their translational potential to treat neurodegenerative disorders.
Natural Products in the Management of Neurodegenerative Diseases
(Springer Nature, 2024-05-16) Goyal, Rajat; Mittal, Pooja; Gautam, Rupesh K.; Kamal, Mohammad Amjad; Perveen, Asma; Garg, Vandana; Alexiou, Athanasios; Saboor, Muhammad; Haque, Shafiul; Farhana, Aisha; Papadakis, Marios; Ashraf, Ghulam Md
"Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of mortality. Natural derivatives are more efficacious in various preclinical models of neurodegenerative illnesses. These natural compounds include phytoconstituents in herbs, vegetables, fruits, nuts, and marine and freshwater flora, with remarkable efficacy in mitigating neurodegeneration and enhancing cognitive abilities in preclinical models. According to the latest research, the therapeutic activity of natural substances can be increased by adding phytoconstituents in nanocarriers such as nanoparticles, nanogels, and nanostructured lipid carriers. They can enhance the stability and specificity of the bioactive compounds to a more considerable extent. Nanotechnology can also provide targeting, enhancing their specificity to the respective site of action. In light of these findings, this article discusses the biological and therapeutic potential of natural products and their bioactive derivatives to exert neuroprotective effects and some clinical studies assessing their translational potential to treat neurodegenerative disorders. Graphical Abstract Common mechanisms, therapeutic targets, and molecular pathogenesis of neurodegeneration. It is focused on the biological and therapeutic potential of natural products and their bioactive derivatives to exert a neuroprotective effect on the pathologies of neurodegenerative diseases."