Browsing by Author "Haque, Md Aminul"

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A comprehensive review on genetic polymorphisms in drug metabolism and response: unveiling impacts and implications
(BRAC University, 2025-01) Islam, Md. Asshiamul; Haque, Md Aminul
This thesis adds to the expanding knowledge base on the influence of genetic variations on the way drugs are processed and how individuals respond to them. The knowledge acquired from this research has the capacity to provide information and improve therapeutic procedures, ultimately leading to the development of more individualised and efficient medication. Comprehending the significance of genetic variations in drug metabolism and response is crucial for customising efficient and individualised treatment. This thesis investigates the complex correlation between genetic differences and their impact on metabolism and the responsiveness to medicinal interventions. This study thoroughly examines the available literature and empirical evidence to investigate the processes by which genetic variations affect drug metabolic pathways, effectiveness, and adverse responses. Furthermore, this thesis examines the consequences of these discoveries on clinical practice and the formulation of precision medicine initiatives. The study utilises a multidisciplinary methodology, combining genomic data, pharmacokinetic investigations, and clinical observations to understand the intricacies linked to drug metabolism. The focus is on comprehending the impact of particular genetic variations on the function of important drug-metabolizing enzymes, such as cytochrome P450s and UDP-glucuronosyltransferases. This thesis seeks to gain a comprehensive understanding of the relationship between genetic diversity and variations in medication response among individuals by conducting a thorough assessment of current research and analysing relevant case studies.
A narrative review on the possible causes of insulin resistance
(BRAC University, 2025) Sabbib, Zobair Mohaimin; Haque, Md Aminul
Insulin resistance is a multifactorial condition that significantly contributes to the development of type 2 diabetes, obesity and cardiovascular diseases. While traditionally linked to obesity and sedentary lifestyles, recent research reveals a more complex etiology involving behavioral, nutritional, endocrine, genetic, environmental, and cellular factors. This review explores both established and emerging contributors to insulin resistance including poor dietary habits, physical inactivity, chronic stress, circadian rhythm disruption and micronutrient deficiencies. Hormonal imbalances particularly involving cortisol, thyroid and sex hormones are examined for their impact on insulin signaling. Additionally, chronic inflammation, oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress are highlighted as key intracellular mechanisms reducing insulin sensitivity. The review also considers fewer known influences such as alterations in gut microbiota, exposure to endocrine disrupting chemicals, early developmental conditions and epigenetic changes. By integrating these diverse factors this paper aims to provide a comprehensive understanding of insulin resistance and its multifaceted origins.
A narrative review on the possible causes of insulin resistance
(BRAC University, 2025-08) Sabbib, Zobair Mohaimin; Haque, Md Aminul
Insulin resistance is a multifactorial condition that significantly contributes to the development of type 2 diabetes, obesity and cardiovascular diseases. While traditionally linked to obesity and sedentary lifestyles, recent research reveals a more complex etiology involving behavioral, nutritional, endocrine, genetic, environmental, and cellular factors. This review explores both established and emerging contributors to insulin resistance including poor dietary habits, physical inactivity, chronic stress, circadian rhythm disruption and micronutrient deficiencies. Hormonal imbalances particularly involving cortisol, thyroid and sex hormones are examined for their impact on insulin signaling. Additionally, chronic inflammation, oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress are highlighted as key intracellular mechanisms reducing insulin sensitivity. The review also considers fewer known influences such as alterations in gut microbiota, exposure to endocrine disrupting chemicals, early developmental conditions and epigenetic changes. By integrating these diverse factors this paper aims to provide a comprehensive understanding of insulin resistance and its multifaceted origins.
An efficient approach for recyclable waste detection and classification using image processing techniques
(BRAC University, 2023-01) Chowdhury, Prabal Kumar; Islam, Md. Aminul; Haque, Md Aminul; Alam, Md. Ashraful
One of the world’s most pressing issues right now is the lack of a competent waste management system, particularly in emerging and underdeveloped countries. Re cycling solid waste, which comprises numerous dangerous non-biodegradable sub stances like glass, metals, plastics, etc., is the most essential step in reducing waste related issues in the environment. Typically, collected waste includes all types of waste that must be thoroughly sorted to recycle efficiently. Most countries use man ual waste sorting techniques, which are efficient. Nevertheless, the waste sorting process by human being is not safe as there is always a risk of exposing them selves to toxic wastes, which could be serious for their health. Our thesis presents a Deep Learning technique based on computer vision for automatically identifying waste. To construct the model, we used Convolutional Neural Networks, real-time object detection systems, such as YOLOv5 and YOLOv7, as well as several trans fer learning-based architectures, including VGG16, MobileNet, Inception-Resnet-v2. The model is trained on numerous images for each type of waste to ensure no overfit ting and greater accuracy. The highest accuracy we achieved for our waste detection model YOLOv5x is 93.7%.