Browsing by Author "Gupta, Gaurav"

Now showing 1 - 2 of 2

Development and Performance Analysis of Machine Learning Methods for Predicting Depression Among Menopausal Women
(Frontier Scientific Publishing, 2023-07-11) Shopnil Akash; Baeza, Javiera; Mahmood, Sajjat; Mukerjee, Nobendu; Subramaniyan, Vetriselvan; Islam, Md. Rezaul; Gupta, Gaurav; Rajakumari, Vinibha; Chinni, Suresh V.; Ramachawolran, Gobinath; Saleh, Fayez M.; Albadrani, Ghadeer M.; Sayed, Amany A.; Abdel-Daim, Mohamed M.
The Lassa virus (LASV), an RNA virus prevalent in West and Central Africa, causes severe hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or vaccines exist. Two crucial proteins, LASV glycoprotein and nucleoprotein, play vital roles in pathogenesis and are potential therapeutic targets. As effective treatments for many emerging infections remain elusive, cutting-edge drug development approaches are essential, such as identifying molecular targets, screening lead molecules, and repurposing existing drugs. Bioinformatics and computational biology expedite drug discovery pipelines, using data science to identify targets, predict structures, and model interactions. These techniques also facilitate screening leads with optimal drug-like properties, reducing time, cost, and complexities associated with traditional drug development. Researchers have employed advanced computational drug design methods such as molecular docking, pharmacokinetics, drug-likeness, and molecular dynamics simulation to investigate evodiamine derivatives as potential LASV inhibitors. The results revealed remarkable binding affinities, with many outperforming standard compounds. Additionally, molecular active simulation data suggest stability when bound to target receptors. These promising findings indicate that evodiamine derivatives may offer superior pharmacokinetics and drug-likeness properties, serving as a valuable resource for professionals developing synthetic drugs to combat the Lassa virus.
Nutraceuticals and Mitochondrial Oxidative Stress
(Daffodil International University, 2022-07-07) Allam, Venkata Sita Rama Raju; Paudel, Keshav Raj; Gupta, Gaurav; Singh, Sachin Kumar; Vishwas, Sukriti; Gulati, Monica; Gupta, Saurabh; Chaitanya, M. V. N. L.; Jha, Niraj Kumar; Gupta, Piyush Kumar; Patel, Vyoma K.; Liu, Gang; Kamal, Mohammad Amjad; Hansbro, Philip M.; Oliver, Brian Gregory George; Chellappan, Dinesh Kumar; Dua, Kamal
is a chronic inflammatory disease primarily characterized by inflammation and reversible bronchoconstriction. It is currently one of the leading causes of morbidity and mortality in the world. Oxidative stress further complicates the pathology of the disease. The current treatment strategies for asthma mainly involve the use of anti-inflammatory agents and bronchodilators. However, long-term usage of such medications is associated with severe adverse effects and complications. Hence, there is an urgent need to develop newer, novel, and safe treatment modalities for the management of asthma. This has therefore prompted further investigations and detailed research to identify and develop novel therapeutic interventions from potent untapped resources. This review focuses on the significance of oxidative stressors that are primarily derived from both mitochondrial and non-mitochondrial sources in initiating the clinical features of asthma. The review also discusses the biological scavenging system of the body and factors that may lead to its malfunction which could result in altered states. Furthermore, the review provides a detailed insight into the therapeutic role of nutraceuticals as an effective strategy to attenuate the deleterious effects of oxidative stress and may be used in the mitigation of the cardinal features of bronchial asthma.