Browsing by Author "Ghosh, Puja"

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    A Decade's Worth of Impact Dox Loaded Liposomes in Anticancer Activity
    (Daffodil International University, 22-11-01) Ghosh, Puja; Tiwari, Himja; Lakkakula, Jaya; Roy, Arpita; Emran, Talha Bin; Rashid, Summya; Alghamdi, Saad; Rajab, Bodour S.; Almehmadi, Mazen; Allahyani, Mamdouh; Aljuaid, Abdulelah; Alsaiari, Ahad Amer; Sharma, Rohit; Babalghith, Ahmad O.
    Clinically approved therapeutics associated with cancer are limited to mostly chemotherapy, surgery and radiotherapy in spite of the advancements in the biomedical field. Due to the cardiotoxicity and uncountable side effects brought by the prevailing treatment strategies, demands are growing for targeted drug delivery using nanomaterials. For this the most commonly used drug, doxorubicin (DOX) is encapsulated within several type of nanovesicles to observe their anticancer activity. Among them, DOX encapsulated liposomes gained popularity because of their clinical success and lower toxicity. To enhance their efficiency and site specific delivery, attempts are made to modify the liposomes by combining them with peptides, aptamers, antibodies etc to develop pH, thermal, UV-sensitive and electro-magnetic liposomal nanocarriers for controlled drug release. The novel strategies for the treatment of Breast, Lung, Liver, Pancreatic, Prostate, Ovarian, Cervical, Blood, Brain and Colon cancer using modified liposomes encapsulating DOX are illustrated in this review.
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    Survey on Prevalence and Management of Fistula at Dhaka Medical College and Hospital
    (Daffodil International University, 2024-10-23) Ghosh, Puja
    Fistula remains a significant public health issue, particularly in developing countries, where inadequate medical infrastructure and social stigma contribute to its prevalence. This study aims to assess the prevalence and management strategies of fistula cases at Dhaka Medical College and Hospital (DMCH), a leading healthcare facility in Bangladesh. We conducted a cross-sectional survey involving 150 patients diagnosed with fistula between May and June 2024. As per this pie chart, 42% responders replied that they have been known about fistula. In this investigation, 35% participants replied that they have been affected by fistula. Additionally, 65% responders retorted that they haven’t affected by fistula. As per this chart, 40% participants replied that they have been affected by obstetric fistula. In this chart, 33% responders replied that they have been felt pus drainage near the anal opening. As per this investigation, 30% responders replied that they have been taken laxatives for relieving fistula. Additionally, 18% responders replied that they have been taken anxiolytics, 15% responders replied that they have been taken antibiotics & 14% responders replied that they have been taken vasodilators for relieving fistula. According to this survey, 25% responders replied that they have been observed sepsis and systemic infection due to untreated fistula. As per this chart, most of the responders 70% replied that they have been very satisfied with the quality of care received for fistula at Dhaka Medical College and Hospital. In this survey, 20% responders replied that doctor has been recommended CT scan for diagnosis fistula. This survey underscores the need for enhanced public health initiatives, including community education, early detection programs, and improved healthcare infrastructure, to address the burden of fistula in Bangladesh. Strengthening these areas will not only reduce the prevalence of fistula but also improve the quality of life for affected individuals.