Browsing by Author "Ghosh, Avoy"

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    Hormonal Therapy for Gynecological Cancers
    (Daffodil International University, 2022-02-01) Mitra, Saikat; Lami, Mashia Subha; Ghosh, Avoy; Das, Rajib; Tallei, Trina Ekawati; Fatimawali; Islam, Fahadul; Dhama, Kuldeep; Begum, M Yasmin; Aldahish, Afaf; Chidambaram, Kumarappan; Emran, Talha Bin
    In recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby stopping or slowing cancer growth. Hormone treatment works by preventing hormones from causing cancer cells to multiply. Aromatase inhibitors, anti-estrogens, progestin, estrogen receptor (ER) antagonists, GnRH agonists, and progestogen are effectively used as therapeutics for vulvar cancer, cervical cancer, vaginal cancer, uterine cancer, and ovarian cancer. Hormone replacement therapy has a high success rate. In particular, progestogen and estrogen replacement are associated with a decreased incidence of gynecological cancers in women infected with human papillomavirus (HPV). The activation of estrogen via the transcriptional functionality of ERα may either be promoted or decreased by gene products of HPV. Hormonal treatment is frequently administered to patients with hormone-sensitive recurring or metastatic gynecologic malignancies, although response rates and therapeutic outcomes are inconsistent. Therefore, this review outlines the use of hormonal therapy for gynecological cancers and identifies the current knowledge gaps.
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    Indole Alkaloids From Marine Resources: Understandings From Therapeutic Point of View To Treat Cancers
    (Chemico-Biological Interactions, 2023-08-28) Islam, Fahadul; Dehbia, Zerrouki; Zehravi, Mehrukh; Das, Rajib; Sivakumar, M.; Krishnan, Karthickeyan; Billah, Abdul Ajeed Mohathasim; Bose, Bharadhan; Ghosh, Avoy; Paul, Shyamjit; Nainu, Firzan; Ahmad, Irfan; Emran, Talha Bin
    Cancer is the leading cause of mortality all over the world. Scientific investigation has demonstrated that disruptions in the process of autophagy are frequently interrelated with the emergence of cancer. Hence, scientists are seeking permanent solutions to counter the deadly disease. Indole alkaloids have been extensively studied and are acknowledged to exhibit several bioactivities. The current state of disease necessitates novel pharmacophores development. In recent decades, indole alkaloids have become increasingly significant in cancer treatment and are also used as adjuvants. A substantial amount of pharmacologically active molecules come from indole alkaloids, which are widely distributed in nature. Indole alkaloids derived from marine organisms show immense potential for therapeutic applications and seem highly effective in cancer treatment. A couple of experiments have been conducted preclinically to investigate the possibility of indole alkaloids in cancer treatment. Marine-derived indole alkaloids possess the ability to exhibit anticancer properties through diverse antiproliferative mechanisms. Certain indole alkaloids, including vincristine and vinblastine, were verified in clinical trials or are presently undergoing clinical assessments for preventing and treating cancer. Indole alkaloids from marine resources hold a significant functionality in identifying new antitumor agents. The current literature highlights recent advancements in indole alkaloids that appear to be anticancer agents and the underlying mechanisms. © 2023 Elsevier B.V.