Browsing by Author "Das, Rajib"

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Cruciferous Vegetables as a Treasure of Functional Foods Bioactive Compounds
(Daffodil International University, 2022-08-09) Mitra, Saikat; Emran, Talha Bin; Chandran, Deepak; Zidan, B M Redwan Matin; Das, Rajib; Mamada, Sukamto S.; Masyita, Ayu; Salampe, Mirnawati; Nainu, Firzan; Khandaker, Mayeen Uddin; Idris, Abubakr M; Simal-Gandara, Jesus
In the past few years, phytochemicals from natural products have gotten the boundless praise in treating cancer. The promising role of cruciferous vegetables and active components contained in these vegetables, such as isothiocyanates, indole-3-carbinol, and isothiocyanates, has been widely researched in experimental in vitro and in vivo carcinogenesis models. The chemo preventive agents produced from the cruciferous vegetables were recurrently proven to affect carcinogenesis throughout the onset and developmental phases of cancer formation. Likewise, findings from clinical investigations and epidemiological research supported this statement. The anticancer activities of these functional foods bioactive compounds are closely related to their ability to upregulate p53 and its related target genes, e.g., p21. As the "guardian of the genome," the p53 family (p53, p63, and p73) plays a pivotal role in preventing the cancer progression associated with DNA damage. This review discusses the functional foods bioactive compounds derived from several cruciferous vegetables and their use in altering the tumor-suppressive effect of p53 proteins. The association between the mutation of p53 and the incidence of gastrointestinal malignancies (gastric, small intestine, colon, liver, and pancreatic cancers) is also discussed. This review contains crucial information about the use of cruciferous vegetables in the treatment of gastrointestinal tract malignancies.
Diallyl Disulfide
(Daffodil International University, 2022-08-12) Mitra, Saikat; Das, Rajib; Emran, Talha Bin; Labib, Rafiuddin Khan; -E-Tabassum, Noor; Islam, Fahadul; Sharma, Rohit; Ahmad, Islamudin; Nainu, Firzan; Chidambaram, Kumarappan; Alhumaydhi, Fahad A.; Chandran, Deepak; Capasso, Raffaele; Wilairatana, Polrat
Cancer is a life-threatening disease caused by the uncontrolled division of cells, which culminates in a solid mass of cells known as a tumor or liquid cancer. It is the leading cause of mortality worldwide, and the number of cancer patients has been increasing at an alarming rate, with an estimated 20 million cases expected by 2030. Thus, the use of complementary or alternative therapeutic techniques that can help prevent cancer has been the subject of increased attention. Garlic, the most widely used plant medicinal product, exhibits a wide spectrum of biological activities, including antibacterial, hypo-lipidemic, antithrombotic, and anticancer effects. Diallyl disulfide (DADS) is a major organosulfur compound contained within garlic. Recently, several experimental studies have demonstrated that DADS exhibits anti-tumor activity against many types of tumor cells, including gynecological cancers (cervical cancer, ovarian cancer), hematological cancers (leukemia, lymphoma), lung cancer, neural cancer, skin cancer, prostate cancer, gastrointestinal tract and associated cancers (esophageal cancer, gastric cancer, colorectal cancer), hepatocellular cancer cell line, etc. The mechanisms behind the anticancer action of DADS include epithelial-mesenchymal transition (EMT), invasion, and migration. This article aims to review the available information regarding the anti-cancer potential of DADS, as well as summarize its mechanisms of action, bioavailability, and pharmacokinetics from published clinical and toxicity studies.
Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives
(Daffodil International University, 2022-05-29) Semwal, Prabhakar; Painuli, Sakshi; Abu-Izneid, Tareq; Rauf, Abdur; Sharma, Anshu; Daştan, Sevgi Durna; Kumar, Manoj; Alshehri, Mohammed M.; Taheri, Yasaman; Das, Rajib; Mitra, Saikat; Emran, Talha Bin; Sharifi-, Javad; Rad, Javad Sharifi-; Calina, Daniela; Cho, William C.
Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro, in vivo, and clinical studies reporting the diosgenin’s pharmacological effects and to discuss the safety issues. Preclinical studies have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical investigations have demonstrated diosgenin’s nontoxic nature and promising benefits on cognitive function and menopause. However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a better knowledge of the diosgenin’s safety profile.
Fucoxanthin
(Daffodil International University, 2022-08-02) Das, Ayan; Mumu, Mumtaza; Emran, Talha Bin; Mitra, Saikat; Islam, Fahadul; Roy, Arpita; Karim, Md. Mobarak; Das, Rajib; Park, Moon Nyeo; Chandran, Deepak; Sharma, Rohit; Khandaker, Mayeen Uddin; Idris, Abubakr M.; Kim, Bonglee
Fucoxanthin (FX) is a special carotenoid having an allenic bond in its structure. FX is extracted from a variety of algae and edible seaweeds. It has been proved to contain numerous health benefits and preventive effects against diseases like diabetes, obesity, liver cirrhosis, malignant cancer, etc. Thus, FX can be used as a potent source of both pharmacological and nutritional ingredient to prevent infectious diseases. In this review, we gathered the information regarding the current findings on antimicrobial, antioxidant, anti-inflammatory, skin protective, anti-obesity, antidiabetic, hepatoprotective, and other properties of FX including its bioavailability and stability characteristics. This review aims to assist further biochemical studies in order to develop further pharmaceutical assets and nutritional products in combination with FX and its various metabolites.
Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities
(MDPI Publications, 2023-11-23) Islam, Fahadul; Labib, Rafiuddin Khan; Zehravi, Mehrukh; Lami, Mashia Subha; Das, Rajib; Singh, Laliteshwar Pratap; Mandhadi, Jithendar Reddy; Balan, P.; Khan, Jishan; Khan, Sharuk L.; Nainu, Firzan; Nafady, Mohamed H.; Rab, Safia Obaidur; Emran, Talha Bin; Wilairatana, Polrat
The genus Amorphophallus belongs to the family Araceae. Plants belonging to this genus are available worldwide and have been used in traditional medicines since ancient times, mainly in Ayurveda and Unani medical practices. Amorphophallus species are an abundant source of polyphenolic compounds; these are accountable for their pharmacological properties, such as their analgesic, neuroprotective, hepatoprotective, anti-inflammatory, anticonvulsant, antibacterial, antioxidant, anticancer, antiobesity, and immunomodulatory effects, as well as their ability to prevent gastrointestinal disturbance and reduce blood glucose. Moreover, Amorphophallus species contain numerous other classes of chemical compounds, such as alkaloids, steroids, fats and fixed oils, tannins, proteins, and carbohydrates, each of which contributes to the pharmacological effects for the treatment of acute rheumatism, tumors, lung swelling, asthma, vomiting, abdominal pain, and so on. Additionally, Amorphophallus species have been employed in numerous herbal formulations and pharmaceutical applications. There has been no extensive review conducted on the Amorphophallus genus as of yet, despite the fact that several experimental studies are being published regularly discussing these plants' pharmacological properties. So, this review discusses in detail the pharmacological properties of Amorphophallus species. We also discuss phytochemical constituents in the Amorphophallus species and their ethnomedicinal uses and toxicological profiles.
Hormonal Therapy for Gynecological Cancers
(Daffodil International University, 2022-02-01) Mitra, Saikat; Lami, Mashia Subha; Ghosh, Avoy; Das, Rajib; Tallei, Trina Ekawati; Fatimawali; Islam, Fahadul; Dhama, Kuldeep; Begum, M Yasmin; Aldahish, Afaf; Chidambaram, Kumarappan; Emran, Talha Bin
In recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby stopping or slowing cancer growth. Hormone treatment works by preventing hormones from causing cancer cells to multiply. Aromatase inhibitors, anti-estrogens, progestin, estrogen receptor (ER) antagonists, GnRH agonists, and progestogen are effectively used as therapeutics for vulvar cancer, cervical cancer, vaginal cancer, uterine cancer, and ovarian cancer. Hormone replacement therapy has a high success rate. In particular, progestogen and estrogen replacement are associated with a decreased incidence of gynecological cancers in women infected with human papillomavirus (HPV). The activation of estrogen via the transcriptional functionality of ERα may either be promoted or decreased by gene products of HPV. Hormonal treatment is frequently administered to patients with hormone-sensitive recurring or metastatic gynecologic malignancies, although response rates and therapeutic outcomes are inconsistent. Therefore, this review outlines the use of hormonal therapy for gynecological cancers and identifies the current knowledge gaps.
Indole Alkaloids From Marine Resources: Understandings From Therapeutic Point of View To Treat Cancers
(Chemico-Biological Interactions, 2023-08-28) Islam, Fahadul; Dehbia, Zerrouki; Zehravi, Mehrukh; Das, Rajib; Sivakumar, M.; Krishnan, Karthickeyan; Billah, Abdul Ajeed Mohathasim; Bose, Bharadhan; Ghosh, Avoy; Paul, Shyamjit; Nainu, Firzan; Ahmad, Irfan; Emran, Talha Bin
Cancer is the leading cause of mortality all over the world. Scientific investigation has demonstrated that disruptions in the process of autophagy are frequently interrelated with the emergence of cancer. Hence, scientists are seeking permanent solutions to counter the deadly disease. Indole alkaloids have been extensively studied and are acknowledged to exhibit several bioactivities. The current state of disease necessitates novel pharmacophores development. In recent decades, indole alkaloids have become increasingly significant in cancer treatment and are also used as adjuvants. A substantial amount of pharmacologically active molecules come from indole alkaloids, which are widely distributed in nature. Indole alkaloids derived from marine organisms show immense potential for therapeutic applications and seem highly effective in cancer treatment. A couple of experiments have been conducted preclinically to investigate the possibility of indole alkaloids in cancer treatment. Marine-derived indole alkaloids possess the ability to exhibit anticancer properties through diverse antiproliferative mechanisms. Certain indole alkaloids, including vincristine and vinblastine, were verified in clinical trials or are presently undergoing clinical assessments for preventing and treating cancer. Indole alkaloids from marine resources hold a significant functionality in identifying new antitumor agents. The current literature highlights recent advancements in indole alkaloids that appear to be anticancer agents and the underlying mechanisms. © 2023 Elsevier B.V.
Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings From a Therapeutic Viewpoint
(MDPI Publications, 2022-12-29) Emran, Talha Bin; Islam, Fahadul; Nath, Nikhil; Sutradhar, Hriday; Das, Rajib; Mitra, Saikat; Alshahrani, Mohammed Merae; Alhasaniah, Abdulaziz Hassan; Sharma, Rohit
The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits, bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple biological functions, including neuroprotective, antioxidant, anticancer, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. The higher glutathione/oxidized glutathione ratio in 3-NP-induced rats is attributed to the ability of naringin to reduce hydroxyl radical, hydroperoxide, and nitrite. However, although progress has been made in treating these diseases, there are still global concerns about how to obtain a solution. Thus, natural compounds can provide a promising strategy for treating many neurological conditions. Possible therapeutics for neurodegenerative disorders include naringin and naringenin polyphenols. New experimental evidence shows that these polyphenols exert a wide range of pharmacological activity; particular attention was paid to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, as well as other neurological conditions such as anxiety, depression, schizophrenia, and chronic hyperglycemic peripheral neuropathy. Several preliminary investigations have shown promising evidence of neuroprotection. The main objective of this review was to reflect on developments in understanding the molecular mechanisms underlying the development of naringin and naringenin as potential neuroprotective medications. Furthermore, the configuration relationships between naringin and naringenin are discussed, as well as their plant sources and extraction methods.
Natural Small Molecules in Gastrointestinal Tract and Associated s
(Daffodil International University, 22-09-03) Islam, Fahadul; Mitra, Saikat; Emran, Talha Bin; Khan, Zidan; Nath, Nikhil; Das, Rajib; Sharma, Rohit; Al Awadh, Ahmed Abdullah; Park, Moon Nyeo; Kim, Bonglee
Gastric cancer is one of the most common cancers of the gastrointestinal tract. Although surgery is the primary treatment, serious maladies that dissipate to other parts of the body may require chemotherapy. As there is no effective procedure to treat stomach cancer, natural small molecules are a current focus of research interest for the development of better therapeutics. Chemotherapy is usually used as a last resort for people with advanced stomach cancer. Anti-colon cancer chemotherapy has become increasingly effective due to drug resistance and sensitivity across a wide spectrum of drugs. Naturally-occurring substances have been widely acknowledged as an important project for discovering innovative medications, and many therapeutic pharmaceuticals are made from natural small molecules. Although the beneficial effects of natural products are as yet unknown, emerging data suggest that several natural small molecules could suppress the progression of stomach cancer. Therefore, the underlying mechanism of natural small molecules for pathways that are directly involved in the pathogenesis of cancerous diseases is reviewed in this article. Chemotherapy and molecularly-targeted drugs can provide hope to colon cancer patients. New discoveries could help in the fight against cancer, and future stomach cancer therapies will probably include molecularly formulated drugs. Keywords: natural products; cancer; gastrointestinal tract; small molecules; apoptosis
Neuropharmacological Potential of Honokiol and Its Derivatives From Chinese Herb Magnolia Species: Understandings From Therapeutic Viewpoint
(PubMed Central Press, 2023-11-24) Faysal, Md.; Khan, Jishan; Zehravi, Mehrukh; Nath, Nikhil; Singh, Laliteshwar Pratap; Kakkar, Saloni; Perusomula, Rajashekar; Khan, Pathan Amanulla; Nainu, Firzan; Asiri, Mohammed; Khan, Sharuk L.; Das, Rajib; Emran, Talha Bin; Wilairatana, Polrat
Honokiol is a neolignan biphenol found in aerial parts of the Magnolia plant species. The Magnolia plant species traditionally belong to China and have been used for centuries to treat many pathological conditions. Honokiol mitigates the severity of several pathological conditions and has the potential to work as an anti-inflammatory, anti-angiogenic, anticancer, antioxidant, and neurotherapeutic agent. It has a long history of being employed in the healthcare practices of Southeast Asia, but in recent years, a greater scope of research has been conducted on it. Plenty of experimental evidence suggests it could be beneficial as a neuroprotective bioactive molecule. Honokiol has several pharmacological effects, leading to its exploration as a potential therapy for neurological diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), cerebral ischemia, anxiety, depression, spinal cord injury, and so on. So, based on the previous experimentation reports, our goal is to discuss the neuroprotective properties of honokiol. Besides, honokiol derivatives have been highlighted recently as possible therapeutic options for NDs. So, this review focuses on honokiol's neurotherapeutic actions and toxicological profile to determine their safety and potential use in neurotherapeutics.
Pectin
(Scopus, 22-10-31) Emran, Talha Bin; Islam, Fahadul; Mitra, Saikat; Paul, Shyamjit; Nath, Nikhil; Khan, Zidan; Das, Rajib; Chandran, Deepak; Sharma, Rohit; Lima, Clara Mariana Gonçalves; Awadh, Ahmed Abdullah Al; Almazni, Ibrahim Abdullah; Alhasaniah, Abdulaziz Hassan; Guiné, Raquel P. F.
Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing long-term chronic diseases like diabetes and heart disease is an important role of dietary carbohydrates. Colon and breast cancer are among the diseases for which data suggest that modified pectin (MP), specifically modified citrus pectin (MCP), has beneficial effects on the development and spread of malignancies, in addition to its benefits as a soluble dietary fiber. Cellular and animal studies and human clinical trials have provided corroborating data. Although pectin has many diverse functional qualities, this review focuses on various modifications used to develop MP and its benefits for cancer prevention, bioavailability, clinical trials, and toxicity studies. This review concludes that pectin has anti-cancer characteristics that have been found to inhibit tumor development and proliferation in a wide variety of cancer cells. Nevertheless, further clinical and basic research is required to confirm the chemopreventive or therapeutic role of specific dietary carbohydrate molecules.
Pharmacological Potential of Avicennia alba Leaf Extract
(Daffodil International University, 2022-05-06) Mitra, Saikat; Islam, Fahadul; Das, Rajib; Urmee, Humaira; Akter, Aklima; Idris, Abubakr M.; Khandaker, Mayeen Uddin; Almikhlafi, Mohannad A.; Sharma, Rohit; Emran, Talha Bin
Avicennia alba is a mangrove plant that is extensively used to treat severe health issues. This focus of this study was to investigate the antidiabetic, anti-inflammatory, analgesic, and antidiarrheal activities of methanolic extract of A. alba leaves in Swiss albino mouse model. The antidiabetic, anti-inflammatory, analgesic, and antidiarrheal activities of the leaf extract were performed using alloxan-monohydrate, carrageenan-induced paw edema, acetic acid-induced writhing test and the hot plate method, and castor oil-induced method, respectively. The extract was used at doses ranging from 200 to 500 mg/kg to conduct the investigation. Leaf extract at 400 and 500 mg/kg showed potent antidiabetic activity in alloxan-induced diabetic mice. Advanced research is needed to control blood glucose levels and carrageenan paw edema-based anti-inflammatory effects. Both tests showed statistically significant result in a dose-dependent manner. The maximum dose (500 mg/kg) demonstrated potent analgesic activity in both writhing test and hot plate method. The plant extract also showed significant antidiarrheal activity at 400 and 500 mg/kg in experimental mice. However, more research is needed to explore the possible mechanisms and isolate the compounds associated with these bioactivities from the leaf extract of A. alba.
Prospective Multifunctional Roles and Pharmacological Potential of Dietary Flavonoid Narirutin
(Daffodil International University, 2022-04-12) Mitra, Saikat; Lami, Mashia Subha; Uddin, Tanvir Mahtab; Das, Rajib; Islam, Fahadul; Anjum, Juhaer; Hossain, Md. Jamal; Emran, Talha Bin
Plant-based phytochemicals are now being used to treat plenty of physiological diseases. Herbal drugs have gained popularity in recent years because of their strength, purity, and cheap cost-effectiveness. Citrus fruits contain significant amounts of flavanones, which falls to the category of polyphenols. Flavanones occupy a major fraction of the total polyphenols present in the plasma when orange juice is taken highly or in moderate states. Narirutin is a disaccharide derivative available in citrus fruits, primarily dihydroxy flavanone. From a pharmacological viewpoint, narirutin is a bioactive phytochemical with therapeutic efficacy. Many experimental researches were published on the use of narirutin. Anticancer activity, neuroprotection, stress relief, hepatoprotection, anti-allergic activity, antidiabetic activity, anti-adipogenic activity, anti-obesity action, and immunomodulation are a couple of the primary pharmacological properties. Narirutin also has antioxidant, and anti-inflammatory activities. The ultimate goal of this review is to provide the current scenario of pharmacological research with narirutin; to make a better understanding for therapeutic potential of narirutin, as well as its biosynthesis strategies and side effects. Extensive literature searches and studies were undertaken to determine the pharmacological properties of narirutin.
Recent Advances in Respiratory Diseases
(Scopus, 22-09-30) Islam, Fahadul; Muni, Maniza; Mitra, Saikat; Emran, Talha Bin; Chandran, Deepak; Das, Rajib; Rauf, Abdur; Safi, Sher Zaman; Chidambaram, Kumarappan; Dhawan, Manish; Cheon, Chunhoo; Kim, Bonglee
A group of bioactive, isoprenoid pigments known as carotenoids is mostly present in fruits and vegetables. Carotenoids are essential for the prevention of physiological issues, which makes maintaining excellent health easier. They are effective functional ingredients with potent health-promoting properties that are widely present in our food and linked to a decrease in the prevalence of chronic diseases, including respiratory diseases. Respiratory infections are the primary cause of death and life-threatening conditions globally, wreaking havoc on the global health system. People rely on dietary sources of carotenoids to reduce a plethora of respiratory diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, asthma, and so on. Carotenoids have received a lot of interest recently in several parts of the world due to their therapeutic potential in altering the pathogenic pathways underlying inflammatory respiratory diseases, which may improve disease control and have beneficial health benefits. This review aimed to provide a thorough understanding of the therapeutic potential of dietary carotenoids in the treatment of respiratory diseases and to identify possible candidates for novel therapeutic development.
Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment
(MDPI Publications, 2023-11-07) Al Amin, Md.; Emran, Talha Bin; Khan, Jishan; Zehravi, Mehrukh; Sharma, Indu; Patil, Anasuya; Gupta, Jeetendra Kumar; Jeslin, D.; Krishnan, Karthickeyan; Das, Rajib; Nainu, Firzan; Ahmad, Irfan; Wilairatana, Polrat
Cancer is the leading cause of morbidity and mortality in people throughout the world. There are many signaling pathways associated with cancerous diseases, from which the Mitogen-activated protein kinase (MAPK) pathway performs a significant role in this regard. Apoptosis and proliferation are correlated with MAPK signaling pathways. Plenty of experimental investigations were carried out to assess the role of indole alkaloids in MAPK-mediated cancerous diseases. Previous reports established that indole alkaloids, such as vincristine and evodiamine are useful small molecules in cancer treatment via the MAPK signaling system. Indole alkaloids have the anticancer potential through different pathways. Vincristine and evodiamine are naturally occurring indole alkaloids that have strong anticancer properties. Additionally, much research is ongoing or completed with molecules belonging to this group. The current review aims to evaluate how indole alkaloids affect the MAPK signaling pathway in cancer treatment. Additionally, we focused on the advancement in the role of indole alkaloids, with the intention of modifying the MAPK signaling pathways to investigate potential new anticancer small molecules. Furthermore, clinical trials with indole alkaloids in cancer treatment are also highlighted.
Role of Phenolic Compounds in Human Disease
(MDPI, 2021-12-30) Rahman, Md. Mominur; Rahaman, Md. Saidur; Islam, Md. Rezaul; Rahman, Firoza; Mithi, Faria Mannan; Alqahtani, Taha; Almikhlafi, Mohannad A.; Alghamdi, Samia Qasem; Alruwaili, Abdullah S.; Hossain, Md. Sohel; Ahmed, Muniruddin; Das, Rajib; Emran, Talha Bin; Uddin, Md. Sahab
Inflammation is a natural protective mechanism that occurs when the body’s tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit pro-inflammatory mediators’ activity or gene expression, including cyclooxygenase (COX). Various phenolic compounds can also act on transcription factors, such as nuclear factor-κB (NF-κB) or nuclear factor-erythroid factor 2-related factor 2 (Nrf-2), to up-or downregulate elements within the antioxidant response pathways. Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common human ailments, including hypertension, metabolic problems, incendiary infections, and neurodegenerative diseases. The inhibition of the angiotensin-converting enzyme (ACE) by phenolic compounds has been used to treat hypertension. The inhibition of carbohydrate hydrolyzing enzyme represents a type 2 diabetes mellitus therapy, and cholinesterase inhibition has been applied to treat Alzheimer’s disease (AD). Phenolic compounds have also demonstrated anti-inflammatory properties to treat skin diseases, rheumatoid arthritis, and inflammatory bowel disease. Plant extracts and phenolic compounds exert protective effects against oxidative stress and inflammation caused by airborne particulate matter, in addition to a range of anti-inflammatory, anticancer, anti-aging, antibacterial, and antiviral activities. Dietary polyphenols have been used to prevent and treat allergy-related diseases. The chemical and biological contributions of phenolic compounds to cardiovascular disease have also been described. This review summarizes the recent progress delineating the multifunctional roles of phenolic compounds, including their anti-inflammatory properties and the molecular pathways through which they exert anti-inflammatory effects on metabolic disorders. This study also discusses current issues and potential prospects for the therapeutic application of phenolic compounds to various human diseases.
Synergistic Effects of Carotenoids: Therapeutic Benefits on Human Health
(Elsevier, 2024-01-20) Islam, Fahadul; Khan, Jishan; Zehravi, Mehrukh; Das, Rajib; Haque, M. Akiful; Banu, Ahmedi; Parwaiz, Shaikh; Nainu, Firzan; Nafady, Mohamed H.; Shahriar, S. M. Shatil; Hossain, Md. Jamal; Muzammil, Khursheed; Emran, Talha Bin
Carotenoids are naturally occurring compounds that are abundant and possess synergistic properties, contributing to their potential health benefits. This review provides an analysis of synergistic relationships among carotenoid compounds. The concept of synergy is of utmost importance due to the ongoing emphasis on consumer safety issues related to botanical natural products. To date, there is a lack of scientific reports specifically investigating the experimental evidence of synergistic effects associated with carotenoids. The carotenoid compounds purported to exhibit synergistic actions have demonstrated significant efficacy in combating oxidation, neurological diseases, peptic ulcers, tumors, and various other ailments. Furthermore, there have been reports of cancer prevention through apoptosis and the presence of antimicrobial, anti-inflammatory, and estrogenic properties. In addition to the observed combined benefits of carotenoids, this review elucidates the various health advantages associated with carotenoids. Among carotenoids, a substantial amount of data has been reported concerning lycopene. This review also examined the clinical status of the concurrent utilization of carotenoids with other bioactive molecules. As mentioned above, the findings offer valuable insights into the potential advantages of carotenoid compounds when combined, thereby presenting a promising avenue for further investigation in future research activities.
Synergistic effects of carotenoids: Therapeutic benefits on human health
(Scopus, 2024-01) Islam, Fahadul; Khan, Jishan; Zehravi, Mehrukh; Das, Rajib; Haque, M. Akiful; Banu, Ahmedi; Parwaiz, Shaikh; Nainu, Firzan; Nafady, Mohamed H.; Muzammil, Khursheed; Emran, Talha Bin
Carotenoids are naturally occurring compounds that are abundant and possess synergistic properties, contributing to their potential health benefits. This review provides an analysis of synergistic relationships among carotenoid compounds. The concept of synergy is of utmost importance due to the ongoing emphasis on consumer safety issues related to botanical natural products. To date, there is a lack of scientific reports specifically investigating the experimental evidence of synergistic effects associated with carotenoids. The carotenoid compounds purported to exhibit synergistic actions have demonstrated significant efficacy in combating oxidation, neurological diseases, peptic ulcers, tumors, and various other ailments. Furthermore, there have been reports of cancer prevention through apoptosis and the presence of antimicrobial, anti-inflammatory, and estrogenic properties. In addition to the observed combined benefits of carotenoids, this review elucidates the various health advantages associated with carotenoids. Among carotenoids, a substantial amount of data has been reported concerning lycopene. This review also examined the clinical status of the concurrent utilization of carotenoids with other bioactive molecules. As mentioned above, the findings offer valuable insights into the potential advantages of carotenoid compounds when combined, thereby presenting a promising avenue for further investigation in future research activities.
Tacrine Derivatives in Neurological Disorders
(Daffodil International University, 2022-08-18) Mitra, Saikat; Muni, Maniza; Shawon, Nusrat Jahan; Das, Rajib; Emran, Talha Bin; Sharma, Rohit; Chandran, Deepak; Islam, Fahadul; Hossain, Md. Jamal; Safi, Sher Zaman; Sweilam, Sherouk Hussein
Tacrine is a drug used in the treatment of Alzheimer’s disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to its poor therapeutic efficacy and high prevalence of detrimental effects. An attempt was made to understand the molecular mechanisms that underlie tacrine and its analogues influence over neurotherapeutic activity by focusing on modulation of neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, and regulatory role in gene and protein expression, energy metabolism, Ca2+ homeostasis modulation, and osmotic regulation. Regardless of this, analogues of tacrine are considered as a model inhibitor of cholinesterase in the therapy of Alzheimer’s disease. The variety both in structural make-up and biological functions of these substances is the main appeal for researchers’ interest in them. A new paradigm for treating neurological diseases is presented in this review, which includes treatment strategies for Alzheimer’s disease, as well as other neurological disorders like Parkinson’s disease and the synthesis and biological properties of newly identified versatile tacrine analogues and hybrids. We have also shown that these analogues may have therapeutic promise in the treatment of neurological diseases in a variety of experimental systems.
Therapeutic Potential of Marine Macrolides
(Daffodil International University, 22-09-27) Das, Rajib; Rauf, Abdur; Mitra, Saikat; Emran, Talha Bin; Hossain, Md Jamal; Khan, Zidan; Naz, Saima; Ahmad, Bashir; Meyyazhagan, Arun; Pushparaj, Karthika; Wan, Chunpeng Craig; Krishnan, Balamurali; Rengasamy, Kannan RR.; Simal-Gandara, Jesus
The sea is a vast ecosystem that has remained primarily unexploited and untapped, resulting in numerous organisms. Consequently, marine organisms have piqued the interest of scientists as an abundant source of natural resources with unique structural features and fascinating biological activities. Marine macrolide is a top-class natural product with a heavily oxygenated polyene backbone containing macrocyclic lactone. In the last few decades, significant efforts have been made to isolate and characterize macrolides’ chemical and biological properties. Numerous macrolides are extracted from different marine organisms such as marine microorganisms, sponges, zooplankton, molluscs, cnidarians, red algae, tunicates, and bryozoans. Notably, the prominent macrolide sources are fungi, dinoflagellates, and sponges. Marine macrolides have several bioactive characteristics such as antimicrobial (antibacterial, antifungal, antimalarial, antiviral), anti-inflammatory, antidiabetic, cytotoxic, and neuroprotective activities. In brief, marine organisms are plentiful in naturally occurring macrolides, which can become the source of efficient and effective therapeutics for many diseases. This current review summarizes these exciting and promising novel marine macrolides in biological activities and possible therapeutic applications.