Browsing by Author "Bibi, Shabana"

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A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
(Scopus, 22-10-04) Biswas, Partha; Dey, Dipta; Biswas, Polash Kumar; Rahaman, Tanjim Ishraq; Saha, Shuvo; Parvez, Anwar; Khan, Dhrubo Ahmed; Lily, Nusrat Jahan; Saha, Konka; Sohel, Md; Hasan, Mohammad Mehedi; Al Azad, Salauddin; Bibi, Shabana; Hasan, Md. Nazmul; Rahmatullah, Mohammed; Chun, Jaemoo; Rahman, Md. Ataur; Kim, Bonglee
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible for the maintenance of the cancer phenotype; this unique feature in cancer cells may, therefore, be exploited for targeted therapy. Quercetin (QC), a plant-derived bioflavonoid, is known for its ROS scavenging properties and was recently discovered to have various antitumor properties in a variety of solid tumors. Adaptive stress responses may be induced by persistent ROS stress, allowing cancer cells to survive with high levels of ROS while maintaining cellular viability. However, large amounts of ROS make cancer cells extremely susceptible to quercetin, one of the most available dietary flavonoids. Because of the molecular and metabolic distinctions between malignant and normal cells, targeting ROS metabolism might help overcome medication resistance and achieve therapeutic selectivity while having little or no effect on normal cells. The powerful bioactivity and modulatory role of quercetin has prompted extensive research into the chemical, which has identified a number of pathways that potentially work together to prevent cancer, alongside, QC has a great number of evidences to use as a therapeutic agent in cancer stem cells. This current study has broadly demonstrated the function-mechanistic relationship of quercetin and how it regulates ROS generation to kill cancer and cancer stem cells. Here, we have revealed the regulation and production of ROS in normal cells and cancer cells with a certain signaling mechanism. We demonstrated the specific molecular mechanisms of quercetin including MAPK/ERK1/2, p53, JAK/STAT and TRAIL, AMPKα1/ASK1/p38, RAGE/PI3K/AKT/mTOR axis, HMGB1 and NF-κB, Nrf2-induced signaling pathways and certain cell cycle arrest in cancer cell death, and how they regulate the specific cancer signaling pathways as long-searched cancer therapeutics. Keywords: ROS; REDOX imbalance; carcinogenesis; malignant cells; quercetin; cancer stem cells
A Comprehensive Perspective of Traditional Arabic or Islamic Medicinal Plants as an Adjuvant Therapy Against COVID-19
(Elsevier, 2023-01-13) Ahmed, Shabina Ishtiaq; Jamil, Sehrish; Ismatullah, Humaira; Hussain, Rashid; Bibi, Shabana; Khandaker, Mayeen Uddin; Naveed, Aisha; Idris, Abubakr M.; Emran, Talha Bin
COVID-19 is a pulmonary disease caused by SARS-CoV-2. More than 200 million individuals are infected by this globally. Pyrexia, coughing, shortness of breath, headaches, diarrhoea, sore throats, and body aches are among the typical symptoms of COVID-19. The virus enters into the host body by interacting with the ACE2 receptor. Despite many SARS-CoV-2 vaccines manufactured by distinct strategies but any evidence-based particular medication to combat COVID-19 is not available yet. However, further research is required to determine the safety and effectiveness profile of the present therapeutic approaches. In this study, we provide a summary of Traditional Arabic or Islamic medicinal (TAIM) plants' historical use and their present role as adjuvant therapy for COVID-19. Herein, six medicinal plants Aloe barbadensis Miller, Olea europaea, Trigonella foenum-graecum, Nigella sativa, Cassia angustifolia, and Ficus carica have been studied based upon their pharmacological activities against viral infections. These plants include phytochemicals that have antiviral, immunomodulatory, antiasthmatic, antipyretic, and antitussive properties. These bioactive substances could be employed to control symptoms and enhance the development of a possible COVID-19 medicinal synthesis. To determine whether or if these TAIMs may be used as adjuvant therapy and are appropriate, a detailed evaluation is advised.
Chemopreventive Potential of Dietary Nanonutraceuticals for
(Daffodil International University, 2022-07-12) Chopra, Hitesh; Bibi, Shabana; Goyal, Rajat; Gautam, Rupesh K.; Trivedi, Rashmi; Upadhyay, Tarun Kumar; Mujahid, Mohd Hasan; Shah, Mohammad Ajmal; Haris, Muhammad; Khot, Kartik Bhairu; Gopan, Gopika; Singh, Inderbir; Kim, Jin Kyu; Jose, Jobin; Abdel-Daim, Mohamed M.; Alhumaydhi, Fahad A.; Emran, Talha Bin; Kim, Bonglee
There are more than two hundred fifty different types of cancers, that are diagnosed around the world. Prostate cancer is one of the suspicious type of cancer spreading very fast around the world, it is reported that in 2018, 29430 patients died of prostate cancer in the United State of America (USA), and hence it is expected that one out of nine men diagnosed with this severe disease during their lives. Medical science has identified cancer at several stages and indicated genes mutations involved in the cancer cell progressions. Genetic implications have been studied extensively in cancer cell growth. So most efficacious drug for prostate cancer is highly required just like other severe diseases for men. So nutraceutical companies are playing major role to manage cancer disease by the recommendation of best natural products around the world, most of these natural products are isolated from plant and mushrooms because they contain several chemoprotective agents, which could reduce the chances of development of cancer and protect the cells for further progression. Some nutraceutical supplements might activate the cytotoxic chemotherapeutic effects by the mechanism of cell cycle arrest, cell differentiation procedures and changes in the redox states, but in other, it also elevate the levels of effectiveness of chemotherapeutic mechanism and in results, cancer cell becomes less reactive to chemotherapy. In this review, we have highlighted the prostate cancer and importance of nutraceuticals for the control and management of prostate cancer, and the significance of nutraceuticals to cancer patients during chemotherapy.
Computer-Aided Drug Design-Based System Pharmacology Applications for the Treatment of Diabetes Mellitus
(Elsevier, 2023-06-15) Bibi, Shabana; Hasan, Mohammad Mehedi; Hossain, Md. Shahadat; Khan, Muhammad Saad; Yousafi, Qudsia; Islam, Fahadul; Chopra, Hitesh; Kamal, Mohammad Amjad
Diabetes mellitus is a very complicated and long-term disease. Diabetic patients are always at risk of creating more complicated diseases in a very short time, as the damage of body organs is very fast if the situation becomes serious and untreated properly. Until yet there is no such medicine that could properly or completely treat diabetes mellitus. So there is an urgent need for advanced computational methods to identify novel therapeutics in a short time and at cheap rates. In this chapter, we have explained the status of diabetes mellitus, publications records, cases studies, mathematical models, and the importance of computer-aided aided design and its application in network pharmacology for the medicinal research of diabetes mellitus, also highlighted different medicine and potential targets for promoting antidiabetic drug research. More detailed studies of diabetic patients’ data set are required using advanced computational power to facilitate and speed up the antidiabetic drug research.
Design of Multi-Epitope Vaccine for Staphylococcus Saprophyticus
(Daffodil International University, 2022-07-27) Yousaf, Maha; Ullah, Asad; Sarosh, Nida; Abbasi, Sumra Wajid; Ismail, Saba; Bibi, Shabana; Hasan, Mohammad Mehedi; Albadrani, Ghadeer M; Nouh, Nehal Ahmed Talaat; Abdulhakim, Jawaher A; Abdel-Daim, Mohamed M; Emran, Talha Bin
Staphylococcus saprophytic us is a Gram-positive coccus responsible for the occurrence of cystitis in sexually active, young females. While effective antibiotics against this organism exist, resistant strains are on the rise. Therefore, prevention via vaccines appears to be a viable solution to address this problem. In comparison to traditional techniques of vaccine design, computationally aided vaccine development demonstrates marked specificity, efficiency, stability, and safety. In the present study, a novel, multi-epitope vaccine construct was developed against S. saprophyticus by targeting fully sequenced proteomes of its five different strains, which were examined using a pangenome and subtractive proteomic strategy to characterize prospective vaccination targets. The three immunogenic vaccine targets which were utilized to map the probable immune epitopes were verified by annotating the entire proteome. The predicted epitopes were further screened on the basis of antigenicity, allergenicity, water solubility, toxicity, virulence, and binding affinity towards the DRB*0101 allele, resulting in 11 potential epitopes, i.e., DLKKQKEKL, NKDLKKQKE, QDKLKDKSD, NVMDNKDLE, TSGTPDSQA, NANSDGSSS, GSDSSSSNN, DSSSSNNDS, DSSSSDRNN, SSSDRNNGD, and SSDDKSKDS. All these epitopes have the efficacy to cover 99.74% of populations globally. Finally, shortlisted epitopes were joined together with linkers and three different adjuvants to find the most stable and immunogenic vaccine construct. The top-ranked vaccine construct was further scrutinized on the basis of its physicochemical characterization and immunological profile. The non-allergenic and antigenic features of modeled vaccine constructs were initially validated and then subjected to docking with immune receptor major histocompatibility complex I and II (MHC-I and II), resulting in strong contact. In silico cloning validations yielded a codon adaptation index (CAI) value of 1 and an ideal percentage of GC contents (46.717%), indicating a putative expression of the vaccine in E. coli. Furthermore, immune simulation demonstrated that, after injecting the proposed MEVC, powerful antibodies were produced, resulting in the sharpest peaks of IgM + IgG formation (>11,500) within 5 to 15 days. Experimental testing against S. saprophytic us can evaluate the safety and efficacy of these prophylactic vaccination designs.
Design of Multi-Epitope Vaccine for Staphylococcus Saprophyticus
(Daffodil International University, 2022-07-27) Yousaf, Maha; Ullah, Asad; Sarosh, Nida; Abbasi, Sumra Wajid; Ismail, Saba; Bibi, Shabana; Hasan, Mohammad Mehedi; Albadrani, Ghadeer M.; Nouh, Nehal Ahmed Talaat; Abdulhakim, Jawaher A.; Abdel-Daim, Mohamed M.; Emran, Talha Bin
Staphylococcus saprophytic us is a Gram-positive coccus responsible for the occurrence of cystitis in sexually active, young females. While effective antibiotics against this organism exist, resistant strains are on the rise. Therefore, prevention via vaccines appears to be a viable solution to address this problem. In comparison to traditional techniques of vaccine design, computationally aided vaccine development demonstrates marked specificity, efficiency, stability, and safety. In the present study, a novel, multi-epitope vaccine construct was developed against S. saprophyticus by targeting fully sequenced proteomes of its five different strains, which were examined using a pangenome and subtractive proteomic strategy to characterize prospective vaccination targets. The three immunogenic vaccine targets which were utilized to map the probable immune epitopes were verified by annotating the entire proteome. The predicted epitopes were further screened on the basis of antigenicity, allergenicity, water solubility, toxicity, virulence, and binding affinity towards the DRB*0101 allele, resulting in 11 potential epitopes, i.e., DLKKQKEKL, NKDLKKQKE, QDKLKDKSD, NVMDNKDLE, TSGTPDSQA, NANSDGSSS, GSDSSSSNN, DSSSSNNDS, DSSSSDRNN, SSSDRNNGD, and SSDDKSKDS. All these epitopes have the efficacy to cover 99.74% of populations globally. Finally, shortlisted epitopes were joined together with linkers and three different adjuvants to find the most stable and immunogenic vaccine construct. The top-ranked vaccine construct was further scrutinized on the basis of its physicochemical characterization and immunological profile. The non-allergenic and antigenic features of modeled vaccine constructs were initially validated and then subjected to docking with immune receptor major histocompatibility complex I and II (MHC-I and II), resulting in strong contact. In silico cloning validations yielded a codon adaptation index (CAI) value of 1 and an ideal percentage of GC contents (46.717%), indicating a putative expression of the vaccine in E. coli. Furthermore, immune simulation demonstrated that, after injecting the proposed MEVC, powerful antibodies were produced, resulting in the sharpest peaks of IgM + IgG formation (>11,500) within 5 to 15 days. Experimental testing against S. saprophytic us can evaluate the safety and efficacy of these prophylactic vaccination designs. Keywords: pan-genome; immuno-informatics; multi-epitope peptide; docking; MD simulation
Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson's Disease
(Daffodil International University, 2022-08-10) Joy, Delna; Jose, Jobin; Bibi, Shabana; Bandiwadekar, Akshay; Gopan, Gopika; Lima, Clara Mariana Gonçalves; Emran, Talha Bin; Alhumaydhi, Fahad A.; Ashtekar, Harsha; D. S, Sandeep; Conte-Junior, Carlos Adam
The demand for drug delivery systems (DDS) to treat Parkinson’s disease (PD) is still high, and microneedle (MN) assisted transdermal DDS offers enormous potential. Herbal products for PD have been shown to have antioxidant effects in reducing dopaminergic neurons from degeneration. Here, we attempted to incorporate solid lipid nanoparticles (SLNs) of Bacopa monnieri into dissolvable microneedle arrays and evaluate its neuroprotective activity. The bloodless and painless microneedle arrays through the transdermal route deliver the drug across the blood-brain barrier at the desired concentration. The quality by design (QbD) approach was employed for optimizing the SLNs formulations. The mechanical strength, in vitro release studies, ex-vivo permeation investigation, skin irritation test, histopathological studies, biochemical studies, and behavioural tests SLNs loaded microneedle arrays were performed. The microneedle patches obtained were shown to be mechanically robust and were also found to be nonirritant with a decreased degree of bradykinesia, high motor coordination, and balance ability. Compared to systemic delivery systems, such an MN method can achieve a considerably lower effective dose and allow long-term home-based treatment.
Emerging Trends in the Delivery of Resveratrol by Nanostructures
(Daffodil International University, 2022-03-08) Chopra, Hitesh; Bibi, Shabana; Islam, Fahadul; Ahmad, Syed Umair; Olawale, Oluwaseyi Abraham; Alhumaydh, Fahad A.; Marzouki, Riadh; Baig, Atif Amin; Emran, Talha Bin
Resveratrol (RES) is a stilbene group of natural polyphenolic compounds in trees, peanuts, and grapes. RES is revealed with anticancer, antioxidant, anti-inflammatory, and cardioprotective effects. Though it is proven with prominent therapeutic activity, low aqueous solubility, poor bioavailability, and short half-life had hindered its use to exploit the potential. Also, the first-pass metabolism and undergoing enterohepatic recirculation are obscure in the minds of researchers for their in vitro studies. Many approaches have been investigated and shown promising results in manipulating their physicochemical properties to break this barrier. Nanocarriers are one of them to reduce the first-pass metabolism and to overcome other hurdles. This article reviews and highlights such encapsulation technologies. Nanoencapsulated RES improves in vitro antioxidant effect, and this review also highlights the new strategies and the concept behind how resveratrol can be handled and implemented with better therapeutic efficacy.
Fabrication of Silver Nanoparticles from Ziziphus nummularia Fruit Extract
(Daffodil International University, 2022-06-25) Khalil, Muhammad Saqib; Shakeel, Muhammad; Gulfam, Naila; Ahmad, Syed Umair; Aziz, Aamir; Ahmad, Junaid; Bibi, Shabana; Chopra, Hitesh; Alhumaydhi, Fahad A.; Idris, Abubakr M.; Khandaker, Mayeen Uddin; Hassan, Manal Ewaiss; Emran, Talha Bin
Nanoparticles are extensively used in biomedical and biotechnological research. Their large surface area, excellent physical properties, high permeability, and retention effect make them ideal for biomedical applications including diagnosis and treatment. Silver nanoparticles proved to be the safest for therapeutic uses. In the present study, silver nanoparticles (AgNPs) were prepared using various ratios of Ziziphus nummularia fruit extract and silver nitrate solution. The nanoparticles were investigated for hair growth and antibacterial and antifungal activities. Characterization of AgNPs was done by using UV-spectrophotometer, scanning electron microscope (SEM), X-ray diffractometer (XRD), thermogravimeter (TG), energy dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FTIR), and master sizer. UV-spectrophotometer results showed the best ratio 10 : 10 of Z. nummularia fruit aqueous extract to silver solution for nanoparticle production at 400 to 430 nm wavelength. The size of AgNPs was 40 nm as measured by SEM. Characterization of AgNPs through EDX resulted in a silver peak at 3 keV. In contrast, differential scanning calorimetry (DSC) spectra show that the AgNPs are stable up to 160°C. The XED spectra gave 12 nm size of crystallite at 2 theta degree angle. FTIR bands for the metal oxides were recorded at 665 cm-1. Weight loss of the prepared nanoparticles was observed due to moisture loss when subjected to TGA, whereas particle size distribution 0.1 μm to 0.17 μm was recorded by the master seizer. The Z. nummularia fruit aqueous extract-mediated AgNPs were noted highly effective against Gram-positive bacteria compared to ethanolic, methanolic, chloroform, and ethyl acetate extracts of Z. nummularia fruit. The Gram-negative bacteria fungal species showed less sensitivity to AgNPs. The hair growth activity was observed to be higher for AgNPs followed by minoxidil than ethanolic and methanolic extracts of Z. nummularia fruit. These findings have concluded that Z. nummularia-AgNPs have an effective hair growth activity and exhibit several applications in distinctive biomedical and pharmaceutical industries.
Green Metallic Nanoparticles
(Daffodil International University, 2022-04-06) Chopra, Hitesh; Bibi, Shabana; Singh, Inderbir; Hasan, Mohammad Mehedi; Khan, Muhammad Saad; Yousafi, Qudsia; Baig, Atif Amin; Rahman, Md. Mominur; Islam, Fahadul; Emran, Talha Bin; Cavalu, Simona
Current advancements in nanotechnology and nanoscience have resulted in new nanomaterials, which may pose health and environmental risks. Furthermore, several researchers are working to optimize ecologically friendly procedures for creating metal and metal oxide nanoparticles. The primary goal is to decrease the adverse effects of synthetic processes, their accompanying chemicals, and the resulting complexes. Utilizing various biomaterials for nanoparticle preparation is a beneficial approach in green nanotechnology. Furthermore, using the biological qualities of nature through a variety of activities is an excellent way to achieve this goal. Algae, plants, bacteria, and fungus have been employed to make energy-efficient, low-cost, and nontoxic metallic nanoparticles in the last few decades. Despite the environmental advantages of using green chemistry-based biological synthesis over traditional methods as discussed in this article, there are some unresolved issues such as particle size and shape consistency, reproducibility of the synthesis process, and understanding of the mechanisms involved in producing metallic nanoparticles via biological entities. Consequently, there is a need for further research to analyze and comprehend the real biological synthesis-dependent processes. This is currently an untapped hot research topic that required more investment to properly leverage the green manufacturing of metallic nanoparticles through living entities. The review covers such green methods of synthesizing nanoparticles and their utilization in the scientific world.
he experimental significance of isorhamnetin as an effective therapeutic option for cancer: A comprehensive analysis
(Scopus, 2024-07) Biswas, Partha; Kaium, Md Abu Kaium ,; Tareq, Md Mohaimenul Islam; Tauhida, Sadia Jannat; Hossain, Md Ridoy; Siam, Labib Shahriar; Parvez, Anwar; Bibi, Shabana; Hasan, Md Hasibul; Rahman, Md Moshiur; Hosen, Delwar; Sohel, Md; Kame, Mohamed; Alamoudi, Mariam K; Daim, Mohamed M Abdel
Isorhamnetin (C16H12O7), a 3'-O-methylated derivative of quercetin from the class of flavonoids, is predominantly present in the leaves and fruits of several plants, many of which have traditionally been employed as remedies due to its diverse therapeutic activities. The objective of this in-depth analysis is to concentrate on Isorhamnetin by addressing its molecular insights as an effective anticancer compound and its synergistic activity with other anticancer drugs. The main contributors to Isorhamnetin's anti-malignant activities at the molecular level have been identified as alterations of a variety of signal transduction processes and transcriptional agents. These include ROS-mediated cell cycle arrest and apoptosis, inhibition of mTOR and P13K pathway, suppression of MEK1, PI3K, NF-κB, and Akt/ERK pathways, and inhibition of Hypoxia Inducible Factor (HIF)-1α expression. A significant number of in vitro and in vivo research studies have confirmed that it destroys cancerous cells by arresting cell cycle at the G2/M phase and S-phase, down-regulating COX-2 protein expression, PI3K, Akt, mTOR, MEK1, ERKs, and PI3K signaling pathways, and up-regulating apoptosis-induced genes (Casp3, Casp9, and Apaf1), Bax, Caspase-3, P53 gene expression and mitochondrial-dependent apoptosis pathway. Its ability to suppress malignant cells, evidence of synergistic effects, and design of drugs based on nanomedicine are also well supported to treat cancer patients effectively. Together, our findings establish a crucial foundation for understanding Isorhamnetin's underlying anti-cancer mechanism in cancer cells and reinforce the case for the requirement to assess more exact molecular signaling pathways relating to specific cancer and in vivo anti-cancer activities.
Ligand-Based Drug Design of Pinocembrin Derivatives Against Monkey-Pox Disease
(Elsevier, 2023-09-06) Akash, Shopnil; Bibi, Shabana; Yousafi, Qudsia; Ihsan, Awais; Mustafa, Riaz; Farooq, Umar; Kabra, Atul; Alanazi, Mohammad M.; Alanazi, Ashwag S.; Kamaly, Omkulthom Al
Severe pathogen infections, such as Monkeypox disease caused by the Monkeypox virus, easily spread in different animals and then into humans. There is an urge for novel therapeutic options, such as medicine/vaccine development to control it. Therefore, we designed Pinocembrin derivatives and performed in silico analysis such as molecular docking by PyRx software, molecular dynamics (MD) simulations at 100 ns, binding free energy estimation by AMBER20 software, ADMET profile, and Pass prediction. Optimal results were observed for two derivatives (07 and 11), exhibiting interactions with key residues of the selected protein. These interactions were substantiated by a range of structural and energetic parameters, including binding energies, solvation-free energy models, dynamic fluctuations, hydrogen bonding, and solvent accessibility. Notably, ligands 07 and 11 displayed exceptional binding affinities of −10.3 kcal/mol and −9.6 kcal/mol, respectively. RMSD value presented minor abruptions of about 1.2 to 1.3 Å and superimposed structures of selected derivatives complexes with Monkeypox target protein at 0 ns and 100 ns presented minor fluctuation in the native and bounded conformation. Slight instability is noted from the peaks in graphs of RMSD, RMSF, hydrogen bonds (HBs), beta factor (BF), and solvent-accessible surface area (SASA). Based on promising results, we proposed that Pinocembrin derivatives may serve as novel therapeutic agents against Monkeypox infections. Therefore, strongly advocate for further experimental validation through chemical laboratory testing. Such endeavors could pave the way for the development of effective treatments to mitigate the impact of Monkey-Pox disease.
Nanomaterials: A Promising Therapeutic Approach for Cardiovascular Diseases
(Daffodil International University, 2022-02-13) Chopra, Hitesh; Bibi, Shabana; Mishra, Awdhesh Kumar; Tirth, Vineet; Yerramsetty, Sree Vandana; Murali, Sree Varshini; Ahmad, Syed Umair; Mohanta, Yugal Kishore; Attia, Mohamed S.; Algahtani, Ali; Islam, Fahadul; Hayee, Abdul; Islam, Saiful; Baig, Atif Amin; Emran, Talha Bin
Cardiovascular diseases (CVDs) are a primary cause of death globally. A few classic and hybrid treatments exist to treat CVDs. However, they lack in both safety and effectiveness. Thus, innovative nanomaterials for disease diagnosis and treatment are urgently required. The tiny size of nanomaterials allows them to reach more areas of the heart and arteries, making them ideal for CVDs. Atherosclerosis causes arterial stenosis and reduced blood flow. The most common treatment is medication and surgery to stabilize the disease. Nanotechnologies are crucial in treating vascular disease. Nanomaterials may be able to deliver medications to lesion sites after being infused into the circulation. Newer point-of-care devices have also been considered together with nanomaterials. For example, this study will look at the use of nanomaterials in imaging, diagnosing, and treating CVDs.
Nanomedicines in the Management of Alzheimer's Disease
(Daffodil International University, 2022-07-12) Chopra, Hitesh; Bibi, Shabana; Singh, Inderbir; Kamal, Mohammad Amjad; Islam, Fahadul; Alhumaydhi, Fahad A.; Emran, Talha Bin; Cavalu, Simona
Alzheimer’s disease (AD) is a kind of dementia that creates serious challenges for sufferers’ memory, thinking, and behavior. It commonly targeting the aging population and decay the brain cells, despite attempts have been performed to enhance AD diagnostic and therapeutic techniques. Hence, AD remains incurable owing to its complex and multifactorial consequences and still there is lack of appropriate diagnostics/therapeutics option for this severe brain disorder. Therefore, nanotechnology is currently bringing new tools and insights to improve the previous knowledge of AD and ultimately may provide a novel treatment option and a ray of hope to AD patients. Here in this review, we highlighted the nanotechnologies-based findings for AD, in both diagnostic and therapeutic aspects and explained how advances in the field of nanotechnology/nanomedicine could enhance patient prognosis and quality of life. It is highly expected these emerging technologies could bring a research-based revolution in the field of neurodegenerative disorders and may assist their clinical experiments and develop an efficacious drug for AD also. The main aim of review is to showcase readers the recent advances in nanotechnology-based approaches for treatment and diagnosing of AD.
Natural Bioactive Molecules
(International Journal of Molecular Sciences, 2021-11-23) Islam, Fahadul; Bibi, Shabana; Meem, Atkia Farzana Khan; Islam, Md Mohaimenul; Rahaman, Md Saidur; Bepary, Sristy; Rahman, Md Mizanur; Rahman, Md Mominur; Elzaki, Amin; Kajoak, Samih; Osman, Hamid; ElSamani, Mohamed; Khandaker, Mayeen Uddin; M Idris, Abubakr; Emran, Talha Bin
Several coronaviruses (CoVs) have been associated with serious health hazards in recent decades, resulting in the deaths of thousands around the globe. The recent coronavirus pandemic has emphasized the importance of discovering novel and effective antiviral medicines as quickly as possible to prevent more loss of human lives. Positive-sense RNA viruses with group spikes protruding from their surfaces and an abnormally large RNA genome enclose CoVs. CoVs have already been related to a range of respiratory infectious diseases possibly fatal to humans, such as MERS, SARS, and the current COVID-19 outbreak. As a result, effective prevention, treatment, and medications against human coronavirus (HCoV) is urgently needed. In recent years, many natural substances have been discovered with a variety of biological significance, including antiviral properties. Throughout this work, we reviewed a wide range of natural substances that interrupt the life cycles for MERS and SARS, as well as their potential application in the treatment of COVID-19.
Natural Therapeutics and Nutraceuticals for Lung Diseases
(Daffodil International University, 2022-05-20) Rahman, Md. Mominur; Bibi, Shabana; Rahaman, Md. Saidur; Rahman, Firoza; Islam, Fahadul; Khan, Muhammad Saad; Hasan, Mohammad Mehedi; Parvez, Anwar; Hossain, Md. Abid; Maeesa, Saila Kabir; Islam, Md. Rezaul; Najda, Agnieszka; Al-malky, Hamdan S.; Mohamed, Hanan R.H.; AlGwaiz, Hussah I.M.; Awaji j, Aeshah A.; K., Mousa O. Germoush; Kensara, Osama A.; Abdel-Daim, Mohamed M.; Saeed, Mohd; Amjad, Mohammad
Background Lung diseases including chronic obstructive pulmonary disease (COPD), infections like influenza, acute respiratory distress syndrome (ARDS), asthma and pneumonia lung cancer (LC) are common causes of sickness and death worldwide due to their remoteness, cold and harsh climatic conditions, and inaccessible health care facilities. Purpose Many drugs have already been proposed for the treatment of lung diseases. Few of them are in clinical trials and have the potential to cure infectious diseases. Plant extracts or herbal products have been extensively used as Traditional Chinese Medicine (TCM) and Indian Ayurveda. Moreover, it has been involved in the inhibition of certain genes/protiens effects to promote regulation of signaling pathways. Natural remedies have been scientifically proven with remarkable bioactivities and are considered a cheap and safe source for lung disease. Methods This comprehensive review highlighted the literature about traditional plants and their metabolites with their applications for the treatment of lung diseases through experimental models in humans. Natural drugs information and mode of mechanism have been studied through the literature retrieved by Google Scholar, ScienceDirect, SciFinder, Scopus and Medline PubMed resources against lung diseases. Results In vitro, in vivo and computational studies have been explained for natural metabolites derived from plants (like flavonoids, alkaloids, and terpenoids) against different types of lung diseases. Probiotics have also been biologically active therapeutics against cancer, anti-inflammation, antiplatelet, antiviral, and antioxidants associated with lung diseases. Conclusion The results of the mentioned natural metabolites repurposed for different lung diseases especially for SARS-CoV-2 should be evaluated more by advance computational applications, experimental models in the biological system, also need to be validated by clinical trials so that we may be able to retrieve potential drugs for most challenging lung diseases especially SARS-CoV-2.
Revolutionizing Anti-Cancer Drug Discovery Against Breast Cancer and Lung Cancer by Modification of Natural Genistein
(Frontier Scientific Publishing, 2023-09-25) Akash, Shopnil; Bibi, Shabana; Biswas, Partha; Mukerjee, Nobendu; Khan, Dhrubo Ahmed; Hasan, Md. Nazmul; Sultana, Nazneen Ahmeda; Hosen, Md. Eram; Jardan, Yousef A. Bin; Nafidi, Hiba-Allah; Bourhia, Mohammed
Breast and lung cancer are two of the most lethal forms of cancer, responsible for a disproportionately high number of deaths worldwide. Both doctors and cancer patients express alarm about the rising incidence of the disease globally. Although targeted treatment has achieved enormous advancements, it is not without its drawbacks. Numerous medicines and chemotherapeutic drugs have been authorized by the FDA; nevertheless, they can be quite costly and often fall short of completely curing the condition. Therefore, this investigation has been conducted to identify a potential medication against breast and lung cancer through structural modification of genistein. Genistein is the active compound in Glycyrrhiza glabra (licorice), and it exhibits solid anticancer efficiency against various cancers, including breast cancer, lung cancer, and brain cancer. Hence, the design of its analogs with the interchange of five functional groups—COOH, NH2 and OCH3, Benzene, and NH-CH2-CH2-OH—have been employed to enhance affinities compared to primary genistein. Additionally, advanced computational studies such as PASS prediction, molecular docking, ADMET, and molecular dynamics simulation were conducted. Firstly, the PASS prediction spectrum was analyzed, revealing that the designed genistein analogs exhibit improved antineoplastic activity. In the prediction data, breast and lung cancer were selected as primary targets. Subsequently, other computational investigations were gradually conducted. The mentioned compounds have shown acceptable results for in silico ADME, AMES toxicity, and hepatotoxicity estimations, which are fundamental for their oral medication. It is noteworthy that the initial binding affinity was only −8.7 kcal/mol against the breast cancer targeted protein (PDB ID: 3HB5). However, after the modification of the functional group, when calculating the binding affinities, it becomes apparent that the binding affinities increase gradually, reaching a maximum of −11.0 and −10.0 kcal/mol. Similarly, the initial binding affinity was only −8.0 kcal/mol against lung cancer (PDB ID: 2P85), but after the addition of binding affinity, it reached −9.5 kcal/mol. Finally, a molecular dynamics simulation was conducted to study the molecular models over 100 ns and examine the stability of the docked complexes. The results indicate that the selected complexes remain highly stable throughout the 100-ns molecular dynamics simulation runs, displaying strong correlations with the binding of targeted ligands within the active site of the selected protein. It is important to further investigate and proceed to clinical or wet lab experiments to determine the practical value of the proposed compounds.
The Experimental Significance of Isorhamnetin as an Effective Therapeutic Option for Cancer: A Comprehensive Analysis
(IEEE, 2024-06-10) Biswas, Partha; Kaium, Md. Abu; Tareq, Md. Mohaimenul Islam; Tauhida, Sadia Jannat; Hossain, Md Ridoy; Siam, Labib Shahriar; Parvez, Anwar; Bibi, Shabana; Hasan, Md Hasibul; Rahman, Md. Moshiur; Hosen, Delwar; Siddiquee, Md. Ariful Islam; Ahmed, Nasim; Sohel, Md.; Al Azad, Salauddin; Alhadrami, Albaraa H.; Kamel, Mohamed; Alamoudi, Mariam K.; Hasan, Md. Nazmul; Abdel-Daim, Mohamed M.
Isorhamnetin (C16H12O7), a 3'-O-methylated derivative of quercetin from the class of flavonoids, is predominantly present in the leaves and fruits of several plants, many of which have traditionally been employed as remedies due to its diverse therapeutic activities. The objective of this in-depth analysis is to concentrate on Isorhamnetin by addressing its molecular insights as an effective anticancer compound and its synergistic activity with other anticancer drugs. The main contributors to Isorhamnetin's anti-malignant activities at the molecular level have been identified as alterations of a variety of signal transduction processes and transcriptional agents. These include ROS-mediated cell cycle arrest and apoptosis, inhibition of mTOR and P13K pathway, suppression of MEK1, PI3K, NF-κB, and Akt/ERK pathways, and inhibition of Hypoxia Inducible Factor (HIF)-1α expression. A significant number of in vitro and in vivo research studies have confirmed that it destroys cancerous cells by arresting cell cycle at the G2/M phase and S-phase, down-regulating COX-2 protein expression, PI3K, Akt, mTOR, MEK1, ERKs, and PI3K signaling pathways, and up-regulating apoptosis-induced genes (Casp3, Casp9, and Apaf1), Bax, Caspase-3, P53 gene expression and mitochondrial-dependent apoptosis pathway. Its ability to suppress malignant cells, evidence of synergistic effects, and design of drugs based on nanomedicine are also well supported to treat cancer patients effectively. Together, our findings establish a crucial foundation for understanding Isorhamnetin's underlying anti-cancer mechanism in cancer cells and reinforce the case for the requirement to assess more exact molecular signaling pathways relating to specific cancer and in vivo anti-cancer activities.
The Experimental Significance of Isorhamnetin as an Effective Therapeutic Option for Cancer: A Comprehensive Analysis
(Elsevier, 2024-06-10) Biswas, Partha; Kaium, Md. Abu; Tareq, Md. Mohaimenul Islam; Tauhid, Sadia Jannat; Hossain, Md Ridoy; Siam, Labib Shahriar; Parvez, Anwar; Bibi, Shabana; Hasan, Md Hasibul; Rahman, Md. Moshiur; Hosen, Delwar; Siddiquee, Md. Ariful Islam; Ahmed, Nasim; Sohel, Md.; Azad, Salauddin Al; Alhadrami, Albaraa H.; Kamel, Mohamed; Alamoudi, Mariam K.; Hasan, Md. Nazmul; Abdel-Daim, Mohamed M.
Isorhamnetin (C16H12O7), a 3'-O-methylated derivative of quercetin from the class of flavonoids, is predominantly present in the leaves and fruits of several plants, many of which have traditionally been employed as remedies due to its diverse therapeutic activities. The objective of this in-depth analysis is to concentrate on Isorhamnetin by addressing its molecular insights as an effective anticancer compound and its synergistic activity with other anticancer drugs. The main contributors to Isorhamnetin's anti-malignant activities at the molecular level have been identified as alterations of a variety of signal transduction processes and transcriptional agents. These include ROS-mediated cell cycle arrest and apoptosis, inhibition of mTOR and P13K pathway, suppression of MEK1, PI3K, NF-κB, and Akt/ERK pathways, and inhibition of Hypoxia Inducible Factor (HIF)-1α expression. A significant number of in vitro and in vivo research studies have confirmed that it destroys cancerous cells by arresting cell cycle at the G2/M phase and S-phase, down-regulating COX-2 protein expression, PI3K, Akt, mTOR, MEK1, ERKs, and PI3K signaling pathways, and up-regulating apoptosis-induced genes (Casp3, Casp9, and Apaf1), Bax, Caspase-3, P53 gene expression and mitochondrial-dependent apoptosis pathway. Its ability to suppress malignant cells, evidence of synergistic effects, and design of drugs based on nanomedicine are also well supported to treat cancer patients effectively. Together, our findings establish a crucial foundation for understanding Isorhamnetin's underlying anti-cancer mechanism in cancer cells and reinforce the case for the requirement to assess more exact molecular signaling pathways relating to specific cancer and in vivo anti-cancer activities.
The Impact of Mucormycosis (Black Fungus) on SARS-CoV-2-Infected Patients
(Daffodil International University, 22-08-19) Islam, Md. Rezaul; Rahman, Md. Mominur; Ahasan, Md. Tanjimul; Sarkar, Nadia; Akash, Shopnil; Islam, Mahfuzul; Islam, Fahadul; Aktar, Most. Nazmin; Saeed, Mohd; Harun-Or-Rashid, Md.; Hosain, Md. Kawsar; Rahaman, Md. Saidur; Afroz, Sadia; Bibi, Shabana; Rahman, Md. Habibur; Sweilam, Sherouk Hussein
The emergence of various diseases during the COVID-19 pandemic made health workers more attentive, and one of the new pathogens is the black fungus (mucormycosis). As a result, millions of lives have already been lost. As a result of the mutation, the virus is constantly changing its traits, including the rate of disease transmission, virulence, pathogenesis, and clinical signs. A recent analysis revealed that some COVID-19 patients were also coinfected with a fungal disease called mucormycosis (black fungus). India has already categorized the COVID-19 patient black fungus outbreak as an epidemic. Only a few reports are observed in other countries. The immune system is weakened by COVID-19 medication, rendering it more prone to illnesses like black fungus (mucormycosis). COVID-19, which is caused by a B.1.617 strain of the SARS-CoV-2 virus, has been circulating in India since April 2021. Mucormycosis is a rare fungal infection induced by exposure to a fungus called mucormycete. The most typically implicated genera are Mucor rhyzuprhizopusdia and Cunninghamella. Mucormycosis is also known as zygomycosis. The main causes of infection are soil, dumping sites, ancient building walls, and other sources of infection (reservoir words “mucormycosis” and “zygomycosis” are occasionally interchanged). Zygomycota, on the other hand, has been identified as polyphyletic and is not currently included in fungal classification systems; also, zygomycosis includes Entomophthorales, but mucormycosis does not. This current review will be focused on the etiology and virulence factors of COVID-19/mucormycosis coinfections in COVID-19-associated mucormycosis patients, as well as their prevalence, diagnosis, and treatment.